NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
Resource Report
Resource Website
100+ mentions
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NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases (RRID:SCR_012895)
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NIDDK
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government granting agency
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Center with mission to conduct and support medical research and research training and to disseminate science-based information on diabetes and other endocrine and metabolic diseases. The NIDDK supports a wide range of medical research through grants to universities and other medical research institutions across the country.
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diabetes, metabolic disease, digestive, kidney, endocrine, medical research
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recommends: Cell Image Library (CIL) recommends: Biological General Repository for Interaction Datasets (BioGRID) recommends: NIDDK Central Repository recommends: Accelerating Medicines Partnership Type 2 Diabetes Knowledge Portal (AMP-T2D) recommends: Metabolomics Workbench recommends: PeptideAtlas recommends: Network Data Exchange (NDEx) recommends: Mouse Genome Informatics (MGI) recommends: Zebrafish Information Network (ZFIN) recommends: FlyBase recommends: Database of Interacting Proteins (DIP) recommends: WormBase recommends: PhysioNet recommends: Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) recommends: UniProt recommends: dbSNP recommends: DNA DataBank of Japan (DDBJ) recommends: European Nucleotide Archive (ENA) recommends: dbVar recommends: ClinicalTrials.gov recommends: European Variation Archive (EVA) recommends: MGnify recommends: Analysis, Visualization, and Informatics Lab-space (AnVIL) recommends: GenBank recommends: Gene Expression Omnibus (GEO) recommends: miRBase recommends: Database of Genomic Variants Archive (DGVa) recommends: Crystallography Open Database (COD) recommends: Coherent X-Ray Imaging Data Bank (CXIDB) recommends: Biological Magnetic Resonance Data Bank (BMRB) recommends: Worldwide Protein Data Bank (wwPDB) recommends: EMDataResource.org recommends: NCBI Assembly Archive Viewer recommends: Cambridge Crystallographic Data Centre (CCDC) recommends: Inorganic Crystal Structure Database (ICSD) recommends: Structural Biology Grid recommends: ArrayExpress recommends: GenomeRNAi recommends: NCBI database of Genotypes and Phenotypes (dbGap) recommends: Protein Circular Dichroism Data Bank (PCDDB) recommends: Electron Microscopy Data Bank at PDBe (MSD-EBI) recommends: PDBe - Protein Data Bank in Europe recommends: PubChem BioAssay recommends: Japanese Genotype-phenotype Archive (JGA) recommends: ProteomeXchange recommends: IntAct recommends: European Genome phenome Archive recommends: MetaboLights recommends: PubChem Substance recommends: The Immunology Database and Analysis Portal (ImmPort) recommends: STRENDA recommends: Kinetic Models of Biological Systems (KiMoSys) recommends: FLOWRepository recommends: Mass spectrometry Interactive Virtual Environment (MassIVE) recommends: Global Proteome Machine Database (GPM DB) recommends: Cancer Imaging Archive (TCIA) recommends: German Neuroinformatics Node (G-Node) recommends: 1000 Functional Connectomes Project recommends: ChEMBL recommends: Image Data Resource (IDR) recommends: SICAS Medical Image Repository recommends: ZENODO recommends: Dataverse Network Project recommends: NeuroMorpho.Org recommends: Mendeley Data recommends: NIMH Data Archive recommends: NIH Figshare Archive recommends: FigShare recommends: National Addiction and HIV Data Archive Program (NAHDAP) recommends: Dryad Digital Repository recommends: Open Science Framework recommends: OpenNeuro recommends: SPARC Portal lists: Mutant Mouse Resource and Research Center lists: NIDDK Research Resources is affiliated with: Cystic Fibrosis Research and Translation Centers is affiliated with: Nutrition and Obesity Research Centers is affiliated with: O'Brien Urology Centers is affiliated with: Hematology Centers is affiliated with: Polycystic Kidney Disease Research and Translation Centers is affiliated with: O'Brien Kidney Centers is affiliated with: Diabetes Research Centers is affiliated with: Digestive Disease Centers is affiliated with: Centers for Diabetes Translation Research is affiliated with: Pediatric Centers of Excellence in Nephrology is affiliated with: Focal Segmental Glomerulosclerosis in Children and Young Adults Interventional Study is related to: Bridging Interventional Development Gaps is related to: Polycystic Kidney Disease Research Resource Consortium has parent organization: National Institutes of Health is parent organization of: MTOPS Prostate Samples Analysis Consortium is parent organization of: Symptom Score for Benign Prostatic Hyperplasia is parent organization of: Type 1 Diabetes - Rapid Access to Intervention Development is parent organization of: National Diabetes Education Program is parent organization of: Family Investigation of Nephropathy of Diabetes is parent organization of: Frequent Hemodialysis Network Daily Trial is parent organization of: HemBase is parent organization of: NIDDK- National Institute of Diabetes and Digestive and Kidney Diseases Obesity Resources is parent organization of: dkCOIN is parent organization of: National Kidney Disease Education Program is parent organization of: Network of Minority Health Research Investigators is parent organization of: National Endocrine and Metabolic Diseases Information Service is parent organization of: National Diabetes Information Clearinghouse is parent organization of: National Digestive Diseases Information Clearinghouse is parent organization of: National Hematologic Diseases Information Service is parent organization of: National Kidney and Urologic Diseases Information Clearinghouse is parent organization of: Type 1 Diabetes Preclinical Testing Program is parent organization of: Frequent Hemodialysis Network Nocturnal Trial is parent organization of: Boston Area Community Health Survey is parent organization of: Minimally Invasive Surgical Therapies Treatment Consortium for Benign Prostatic Hyperplasia is parent organization of: Focal Segmental Glomerulosclerosis in Children and Young Adults Interventional Study
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Type 1 diabetes, Type 2 diabetes, Diabetes, Digestive disease, Kidney disease, Endocrine disease, Obesity, Blood disease, Liver disease, Urologic disease |
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nlx_inv_1005102 |
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SCR_012895 |
National Institute of Diabetes and Digestive and Kidney Diseases |
2026-08-08 11:59:48 |
156 |
Frequent Hemodialysis Network Nocturnal Trial
Resource Report
Resource Website
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Frequent Hemodialysis Network Nocturnal Trial (RRID:SCR_007014)
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FHN Nocturnal Trial
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clinical trial, resource
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Randomized controlled clinical trial where subjects will be randomized to conventional hemodialysis delivered three days per week home arm or to the six times per week nocturnal home hemodialysis arm which will follow any dialysis prescription provided their prescribed standardized Kt/V is at least 4.0 and treatment time is at least 6.0 hours, six times per week. Subjects were recruited from dialysis units associated with designated Clinical Centers in the U.S. and Canada and followed for 12 months. Primary Outcome Measures: * composite of 12 month mortality and the change over 12 months in left ventricular mass by cine-MRI, * a composite of 12 month mortality and the change over 12 months in the SF-36 RAND physical health composite Secondary Outcome Measures: * cardiovascular structure/funct (change in LV mass over 12 mos), health-related QoL/phys funct (change over 12 mos in PHC), * depression / dis burden (change over 12 mos in Beck Depression Inv.), nutrition (change over 12 mos in serum albumin, cognitive funct (change over 12 mos in TrailMaking Test B), mineral metabolism (change over 12 mos in aveg pre-dialysis serum phosphorus), * clin events (rate of non-access hospital or death * hypertension, anemia
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hemodialysis, home, adult human, kidney, kidney disease
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is listed by: ClinicalTrials.gov is related to: Frequent Hemodialysis Network Daily Trial is related to: NIDDK Information Network (dkNET) has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
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End Stage Renal Disease, Hemodialysis |
NIDDK |
PMID:21775973 PMID:17164834 PMID:17699439 |
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nlx_152829 |
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SCR_007014 |
Frequent Hemodialysis Network (FHN) Nocturnal Trial, Frequent Hemodialysis Network: Nocturnal Trial |
2026-08-11 09:41:29 |
0 |
HALT PKD
Resource Report
Resource Website
1+ mentions
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HALT PKD (RRID:SCR_001529)
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HALT PKD, HALT-PKD
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clinical trial, resource
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Consortium established to design and implement clinical trials of treatments that might slow the progressive loss of renal function in Polycystic Kidney Disease (PKD). Two multicenter randomized, double-blind, placebo controlled clinical trials are running concurrently to study the efficacy of renin-angiotensin-aldosterone system blockade on the progression of cystic disease (kidney volume) and on the decline in renal function in autosomal dominant polycystic kidney disease (ADPKD). Study A is to study whether intensive ACE-I/ARB blockade decrease the progression of cystic disease compared to ACE-I monotherapy patients with early disease, relatively preserved renal function, and high-normal BP or hypertension. Study B is to study whether intensive ACE-I/ARB blockade as compared to ACE-I monotherapy slow the decline in kidney function, end-stage of renal disease, or death in the setting of standard blood pressure control in hypertensive patients with moderately advanced disease.
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treatment, renal function, lisinopril, placebo, telmisartan, male, female, adolescent, adult human
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is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Research Resources has parent organization: Washington University School of Medicine in St. Louis; Missouri; USA
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Polycystic kidney disease, Autosomal dominant polycystic kidney disease |
NIDDK 5U01DK062408 |
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Free, Freely available |
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nlx_152832 |
https://www.niddkrepository.org/studies/halt-pkd/ |
http://www.pkd.wustl.edu/pkdtn/ |
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SCR_001529 |
Polycystic Kidney Disease-Treatment Network |
2026-08-11 09:40:23 |
1 |
Frequent Hemodialysis Network Daily Trial
Resource Report
Resource Website
1+ mentions
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Frequent Hemodialysis Network Daily Trial (RRID:SCR_001527)
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FHN Daily Trial
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clinical trial, resource
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Randomized controlled clinical trial to understand how increasing hemodialysis to six times a week from the standard of three times a week may result in improved heart health. Subjects were recruited from dialysis units associated with designated Clinical Centers in the U.S. and Canada and followed for 1 year. Subjects will be randomized to either conventional hemodialyis Daily HD delivered for at least 2.5 hours (typically 3 to 4 hours), 3 days per week, or to more frequent hemodialysis delivered for 1.5 - 2.75 hours, 6 days per week. The study has two co-primary outcomes: 1) a composite of mortality with the change over 12 months in left ventricular mass by magnetic resonance imaging, and 2) a composite of mortality with the change over 12 months in the SF-36 RAND physical health composite (PHC) quality of life scale. In addition, main secondary outcomes have been designated for each of seven outcome domains: 1) cardiovascular structure and function (change in LV mass), 2) health-related quality of life/physical function (change in the PHC), 3) depression/burden of illness (change in Beck Depression Inventory), 4) nutrition (change in serum albumin), 5) cognitive function (change in the Trail Making Test B), 6) mineral metabolism (change in average predialysis serum phosphorus), and 7) clinical events (rate of non-access hospitalization or death). Hypertension and anemia are also main outcome domains, but without designation of single first priority outcomes.
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hemodialysis, cardiovascular, kidney, heart
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is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) is related to: Frequent Hemodialysis Network Nocturnal Trial has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
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Hemodialysis, End Stage Renal Disease |
NIDDK |
PMID:21091062 PMID:17164834 PMID:17699439 |
Free, Freely available |
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nlx_152828 |
https://www.niddk.nih.gov/news/for-reporters/frequent-hemodialysis-network-daily-trial/Pages/default.aspx |
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SCR_001527 |
Frequent Hemodialysis Network (FHN) Daily Trial |
2026-08-11 09:40:21 |
1 |
NIDDK Information Network (dkNET)
Resource Report
Resource Website
10+ mentions
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NIDDK Information Network (dkNET) (RRID:SCR_001606)
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dkNET
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data or information resource, portal, database, community building portal
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The NIDDK Information Network (dkNET) is a community-based network to serve needs of basic and clinical investigators that includes large pools of data and research resources relevant to mission of National Institute of Diabetes and Digestive and Kidney Disease.
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dknet, data resource, diabetes, kidney, liver, disease, urology, hematology, digestive, nutrition, endocrine, obesity, metabolic
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uses: NIDDK Central Repository uses: Addgene uses: NIF Data Federation uses: Antibody Registry uses: Nuclear Receptor Signaling Atlas uses: GenitoUrinary Development Molecular Anatomy Project uses: Diabetic Complications Consortium uses: National Mouse Metabolic Phenotyping Centers uses: T1DBase uses: Beta Cell Biology Consortium uses: Grants.gov uses: dkNET Community Pilot Funding Opportunities uses: Integrated Grants uses: ClinicalTrials.gov uses: Integrated Animals uses: Intestinal Stem Cell Consortium recommends: Biological General Repository for Interaction Datasets (BioGRID) recommends: Cell Image Library (CIL) recommends: Accelerating Medicines Partnership Type 2 Diabetes Knowledge Portal (AMP-T2D) recommends: NIDDK Central Repository recommends: Network Data Exchange (NDEx) recommends: PeptideAtlas recommends: International Mouse Phenotyping Consortium (IMPC) recommends: FlyBase recommends: Metabolomics Workbench recommends: Zebrafish Information Network (ZFIN) recommends: Mouse Genome Informatics (MGI) recommends: Database of Interacting Proteins (DIP) recommends: UniProt recommends: PhysioNet recommends: Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) recommends: ClinicalTrials.gov recommends: dbVar recommends: Analysis, Visualization, and Informatics Lab-space (AnVIL) recommends: WormBase recommends: dbSNP recommends: GenBank recommends: DNA DataBank of Japan (DDBJ) recommends: Database of Genomic Variants Archive (DGVa) recommends: NCBI Sequence Read Archive (SRA) recommends: MGnify recommends: European Variation Archive (EVA) recommends: European Nucleotide Archive (ENA) recommends: Gene Expression Omnibus (GEO) recommends: NCBI Assembly Archive Viewer recommends: Protein Circular Dichroism Data Bank (PCDDB) recommends: miRBase recommends: Trace Archive recommends: UniProtKB recommends: Coherent X-Ray Imaging Data Bank (CXIDB) recommends: Electron Microscopy Data Bank at PDBe (MSD-EBI) recommends: Worldwide Protein Data Bank (wwPDB) recommends: Biological Magnetic Resonance Data Bank (BMRB) recommends: Crystallography Open Database (COD) recommends: PDBj - Protein Data Bank Japan recommends: Inorganic Crystal Structure Database (ICSD) recommends: Structural Biology Grid recommends: NCBI database of Genotypes and Phenotypes (dbGap) recommends: ArrayExpress recommends: EMDataResource.org recommends: Cambridge Crystallographic Data Centre (CCDC) recommends: PDBe - Protein Data Bank in Europe recommends: Japanese Genotype-phenotype Archive (JGA) recommends: PubChem BioAssay recommends: European Genome phenome Archive recommends: GenomeRNAi recommends: ProteomeXchange recommends: MetaboLights recommends: IntAct recommends: FLOWRepository recommends: Proteomics Identifications (PRIDE) recommends: Global Proteome Machine Database (GPM DB) recommends: Kinetic Models of Biological Systems (KiMoSys) recommends: ChEMBL recommends: Cancer Imaging Archive (TCIA) recommends: Image Data Resource (IDR) recommends: The Immunology Database and Analysis Portal (ImmPort) recommends: PubChem Substance recommends: NeuroMorpho.Org recommends: Cancer Nanotechnology Laboratory (caNanoLab) recommends: SICAS Medical Image Repository recommends: Mass spectrometry Interactive Virtual Environment (MassIVE) recommends: Dryad Digital Repository recommends: ZENODO recommends: NIH Figshare Archive recommends: STRENDA recommends: OpenNeuro recommends: Influenza Research Database (IRD) recommends: 1000 Functional Connectomes Project recommends: Mendeley Data recommends: Open Science Framework recommends: Dataverse Network Project recommends: NIMH Data Archive recommends: FigShare recommends: National Addiction and HIV Data Archive Program (NAHDAP) recommends: SPARC Portal recommends: Vivli is recommended by: National Library of Medicine lists: Diabetic Complications Consortium lists: Nephromine lists: LIPID Metabolites And Pathways Strategy lists: METLIN lists: NIDDK Inflammatory Bowel Disease Genetics Consortium lists: Body Mass Index Calculator lists: Symptom Score for Benign Prostatic Hyperplasia lists: Genetics of Kidneys in Diabetes lists: Type 1 Diabetes - Rapid Access to Intervention Development lists: TEDDY lists: Trans-Institute Angiogenesis Research Program lists: Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease lists: Current Research Information System lists: Healthy People lists: Acute Liver Failure Study Group lists: Collaborative Islet Transplant Registry lists: Diabetes Prevention Type 1 lists: Epidemiology of Diabetes Interventions and Complications lists: NIH Division of Nutrition Research Coordination lists: Human Nutrition Research Information Management lists: Type 1 Diabetes Resource lists: National Diabetes Education Program lists: Pediatric Acute Liver Failure Study lists: Globin Gene Server lists: NIH Chronic Prostatitis Symptom Index lists: Sequencing of Idd regions in the NOD mouse genome lists: Look AHEAD lists: Teen-Longitudinal Assessment of Bariatric Surgery lists: Adult to Adult Living Donor Liver Transplantation Cohort Study lists: Behavior Enhances Drug Reduction of Incontinence lists: BARI 2D lists: Childhood Liver Disease Research and Education Network lists: Standardization of C-peptide measurements lists: CKID A Prospective Cohort Study of Kidney Disease in Children lists: Diabetes Prevention Program lists: Diabetes Prevention Program Outcomes Study lists: Irritable Bowel Syndrome Outcome Study lists: Folic Acid for Vascular Outcome Reduction in Transplantation lists: Type 1 Diabetes TrialNet lists: Diabetes Research in Children Network lists: Diabetic Retinopathy Clinical Research Network lists: Clinical Islet Transplantation Study lists: Nonalcoholic Steatohepatitis Clinical Research Network lists: Drug-Induced Liver Injury Network lists: Family Investigation of Nephropathy of Diabetes lists: Frequent Hemodialysis Network Daily Trial lists: HEALTHY study lists: SISTEr lists: Urinary Incontinence Treatment Network lists: TINSAL-T2D lists: TOMUS lists: Type 1 Diabetes Genetics Consortium lists: Center for Inherited Disease Research lists: Action to Control Cardiovascular Disease Risk in Diabetes Follow-up Study (ACCORDION) lists: Predicting Response to Standardized Pediatric Colitis Therapy (PROTECT) lists: Lifestyle Interventions for Expectant Moms (LIFE-Moms) lists: Hyperglycemia and Pregnancy Outcomes Follow-Up Study Consortium (HAPO-FUS) lists: Nephrotic Syndrome Study Network (NEPTUNE) lists: CKD Biomarkers Consortium lists: Porphyria Consortium lists: Vitamin D to Prevent Type 2 Diabetes (D2d) lists: Glycemic Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) lists: Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) lists: Clinical Islet Transplantation Consortium (CITC) lists: Restoring Insulin Secretion Consortium (RISE) lists: Assessment Serial Evaluation and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) lists: Integrated Islet Distribution Program (IIDP) lists: Human Islet Research Network (HIRN) lists: Rare Kidney Stone Consortium (RKSC) lists: Evaluating Predictors and Interventions in Sphincter of Oddi Dysfunction lists: Efficacy and Mechanisms of Glutamine Dipeptide in the Surgical Intensive Care Unit lists: Intestinal Stem Cell Consortium lists: RiVuR lists: Gastroparesis Clinical Research Consortium lists: Urologic Diseases in America lists: United States Renal Data System lists: HALT PKD lists: Chronic Renal Insufficiency Cohort Study lists: Viral Resistance to Antiviral Therapy of Chronic Hepatitis C lists: Peginterferon and Ribavirin for Pediatric Patients with Chronic Hepatitis C lists: HALT-C Trial lists: TRIGR lists: Treatment Options for type 2 Diabetes in Adolescents and Youth lists: Study of Nutrition in Acute Pancreatitis lists: SEARCH for Diabetes in Youth lists: Organ Procurement and Transplantation Network lists: Nuclear Receptor Signaling Atlas lists: NIH Common Fund lists: Mutant Mouse Resource and Research Center lists: GenitoUrinary Development Molecular Anatomy Project lists: National Mouse Metabolic Phenotyping Centers lists: IPD-MHC- Major Histocompatibility Complex lists: High-dose Ursodiol Therapy of Primary Sclerosing Cholangitis lists: Hepatitis B Research Network lists: Functional Dyspepsia Treatment Trial lists: Cooperative Study Group for Autoimmune Disease Prevention lists: Clinical Outcomes Research Initiative lists: BISC lists: Beta Cell Biology Consortium lists: Autoimmunity Centers of Excellence lists: HemBase lists: Longitudinal Assessment of Bariatric Surgery lists: Minnesota Liver Tissue Cell Distribution System lists: Knockout Mouse Project lists: Immune Tolerance Network (ITN) lists: Accelerating Medicines Partnership Type 2 Diabetes Knowledge Portal (AMP-T2D) lists: ReBuilding a Kidney lists: GOA lists: NURSA Transcriptomine lists: STRING lists: Nuclear Receptor Cistrome lists: EuReGene lists: Embryo Images Normal and Abnormal Mammalian Development lists: Stem Cell Genome Anatomy Projects lists: Eurexpress lists: Gene Expression Database lists: ToppGene Suite lists: GATACA GUDMAP Gene Explorer lists: Knockout Mouse Project Repository lists: Cornell Heart Lung Blood Resource for Optogenetic Mouse Signaling (CHROMus) lists: International Mouse Phenotyping Consortium (IMPC) lists: Juvenile Diabetes Research Foundation lists: NIDDK Central Repository lists: Biospecimens/Biorepositories: Rare Disease-HUB (RD-HUB) lists: Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC) lists: T1DBase lists: NCI Specimen Resource Locator lists: NCBI database of Genotypes and Phenotypes (dbGap) lists: caHUB lists: T1D Exchange lists: NCBI lists: LANDMark BioBanks lists: Diabetes Research Centers lists: Network for Pancreatic Organ Donors with Diabetes lists: Nutrition and Obesity Research Centers lists: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Antibody Validation and Vector Core lists: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Cell Culture and Engineering lists: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Clinical and Translational Core Resource lists: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center Mouse Models and Biobank lists: Baltimore Polycystic Kidney Disease (PKD) Research and Clinical Core Center lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Bioinformatics Resource lists: Boston Area Diabetes Endocrinology Research Center Cell Biology and Morphology Core Facility lists: Boston Area Diabetes Endocrinology Research Center Metabolic Physiology and Energy Balance Core Facility lists: Boston Area Diabetes Endocrinology Research Center Molecular Biology lists: Boston Area Diabetes Endocrinology Research Center Pancreatic Islet lists: Boston Area Diabetes Endocrinology Research Center lists: Boston Area Diabetes Endocrinology Research Center Transgenic lists: Boston Children's Hospital Center of Excellence in Molecular Hematology Mouse Embryonic Stem(ES) Cell and Gene Targeting Core lists: Boston Children's Hospital Center of Excellence in Molecular Hematology lists: Boston Children's Hospital Center of Excellence in Molecular Hematology Stem Cell Engineering and Analysis Core lists: Boston Children's Hospital Center of Excellence in Molecular Hematology Zebrafish Core lists: Boston Nutrition and Obesity Research Centers Adipose Biology and Nutrient Metabolism Core lists: Boston Nutrition and Obesity Research Centers Administrative Core lists: Boston Nutrition and Obesity Research Centers Epidemiology and Genetics Core lists: Boston Nutrition and Obesity Research Centers Functional Genomics and Bioinformatics Core lists: Boston Nutrition and Obesity Research Centers lists: Boston Nutrition and Obesity Research Centers Transgenic Core lists: Center for American Indian and Alaska Native Diabetes Translational Research Administrative Core lists: Center for American Indian and Alaska Native Diabetes Translational Research National Resource lists: Center for American Indian and Alaska Native Diabetes Translational Research Resource lists: Center for American Indian and Alaska Native Diabetes Translational Research lists: Center for Iron and Heme Disorders at the University of Utah Administrative Core lists: Center for Iron and Heme Disorders at the University of Utah Iron and Heme Core lists: Center for Iron and Heme Disorders at the University of Utah Metabolomics Core lists: Center for Iron and Heme Disorders at the University of Utah Mutation Generation and Detection Core lists: Center for Iron and Heme Disorders at the University of Utah lists: Center for the Study of Inflammatory Bowel Disease Clinical Core lists: Center for the Study of Inflammatory Bowel Disease Genetic Animal Models Core lists: Center for the Study of Inflammatory Bowel Disease Genetics Genomics and Molecular Biology Core lists: Center for the Study of Inflammatory Bowel Disease Immunology Core lists: Center for the Study of Inflammatory Bowel Disease Morphology Core lists: Center for the Study of Inflammatory Bowel Disease lists: Centers for Diabetes Translation Research lists: Chicago Center for Diabetes Translation Research Health Disparities and Community-Based Participatory Research Core lists: Chicago Center for Diabetes Translation Research Outcomes Improvement Core lists: Chicago Center for Diabetes Translation Research Quantitative Analysis Core lists: Chicago Center for Diabetes Translation Research lists: Cincinnati Digestive Health Center Clinical Component-Data Analysis and Management lists: Cincinnati Children's Hospital Digestive Health Center lists: Cincinnati Digestive Health Center Integrative Morphology lists: Cincinnati Digestive Health Center Pluripotent Stem Cell and Organoid Core lists: Cincinnati Digestive Health Center lists: Cleveland Digestive Diseases Research Core Center lists: Cleveland Digestive Diseases Research Core Facilities lists: Columbia Diabetes Research Center Advanced Tissue Pathology and Imaging Core Facility lists: Columbia Diabetes Research Center Flow Cytometry and Cell Sorting Core Facility lists: Columbia Diabetes Research Center Mouse Metabolic Function and Phenotyping Core Facility lists: Columbia Diabetes Research Center lists: Columbia Diabetes Research Center Translational Biomarker Analytical Core Facility lists: Columbia University George M. O'Brien Urology Center lists: CURE - Digestive Diseases Research Center Administrative Core lists: CURE - Digestive Diseases Research Center Animal Models Core lists: CURE - Digestive Diseases Research Center Human Studies Core lists: CURE - Digestive Diseases Research Center Molecular Biology and Peptidomics Core lists: CURE - Digestive Diseases Research Center Morphology and Imaging Core lists: CURE - Digestive Diseases Research Center lists: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Clinical Translational Core lists: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Histology Core lists: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Michael Hooker Microscopy Core Facility lists: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Molecular Biology Core lists: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Mouse Models Core lists: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Mucus and Mucin Biochemistry and Biophysics Core lists: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Pre-Clinical Core lists: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center lists: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Tissue Procurement and Cell Culture Core lists: Cystic Fibrosis Center - University of California San Francisco lists: Cystic Fibrosis Center University of Pittsburgh lists: Cystic Fibrosis Center - University of Washington Administrative and Enrichment Core lists: Cystic Fibrosis Center - University of Washington Clinical Core lists: University of Washington Genomics Core Cystic Fibrosis Research Translation Center and Research Development Program lists: Cystic Fibrosis Center - University of Washington Host Response Core lists: Cystic Fibrosis Center - University of Washington Microbiology Core lists: Cystic Fibrosis Center - University of Washington lists: Cystic Fibrosis Research and Translation Centers lists: Digestive Disease Centers lists: Duke O'Brien Center for Kidney Research Animal Models Core lists: Duke O'Brien Center for Kidney Research Clinical and Translational Core lists: Duke O'Brien Center for Kidney Research Renal Genomics Core lists: Duke O'Brien Center for Kidney Research lists: Einstein-Mount Sinai Diabetes Research Center Animal Physiology Core Facility lists: Einstein-Mount Sinai Diabetes Research Center Biomarker Analytic Research Core Facility lists: Einstein-Mount Sinai Diabetes Research Center Human Islet and Adenovirus Core Facility lists: Einstein-Mount Sinai Diabetes Research Center lists: Einstein-Mount Sinai Diabetes Research Center Stable Isotope and Metabolomics Core Facility lists: Einstein-Mount Sinai Diabetes Research Center Translational Research Core Facility lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Antibody Technology lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Arnold Library lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Comparative Medicine lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Electron Microscopy lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Experimental Histopathology Shared Resource lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Flow Cytometry lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Genomics Shared Resource lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Glassware Services lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Proteomics Resource lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Research Freezers and Sample Storage Resource lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Scientific Imaging lists: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Specimen Processing/Research Cell Bank lists: George M. O'Brien Kidney Center at Yale Human Genetics and Clinical Research Core lists: George M. O'Brien Kidney Center at Yale Mouse Genetics and Cell Line Core lists: George M. O'Brien Kidney Center at Yale Renal Physiology Core lists: George M. O'Brien Kidney Center at Yale lists: George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Animal Models Core lists: George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Cell Biology and Imaging Core lists: George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Clinical and Translational Core lists: George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Physiology Core lists: George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center lists: Georgia Center for Diabetes Translation Research Design and Evaluation Core Facility lists: Georgia Center for Diabetes Translation Research Disparities Core lists: Georgia Center for Diabetes Translation Research Engagement and Behavior Change Core lists: Georgia Center for Diabetes Translation Research lists: Gregory Fleming James Cystic Fibrosis Research Center Assay Core lists: Gregory Fleming James Cystic Fibrosis Research Center Cell Model and Evaluation Core lists: Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Animal Models Core lists: Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Clinical and Translational Core lists: Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Transmembrane Conductance Regulator Expression Core lists: Gregory Fleming James Cystic Fibrosis Research Center lists: Health Delivery Systems Center for Diabetes Translational Research California State Resource Program lists: Health Delivery Systems Center for Diabetes Translational Research Diabetes and Obesity Prevention Core lists: Health Delivery Systems Center for Diabetes Translational Research Health Disparities Core lists: Health Delivery Systems Center for Diabetes Translational Research Health Information Technology Core lists: Health Delivery Systems Center for Diabetes Translational Research lists: Hematology Centers lists: Indiana University School of Medicine Center for Diabetes and Metabolic Diseases Islet and Physiology Core Facility lists: Indiana Diabetes Research Center Microscopy Core Facility lists: Indiana Diabetes Research Center lists: Indiana Diabetes Research Center Swine Core lists: Indiana Diabetes Research Center Translation Core Facility lists: Indiana O'Brien Center for Advanced Microscopic Analysis Administration Core lists: Indiana O'Brien Center for Advanced Microscopic Analysis Biosensor Development Core lists: Indiana O'Brien Center for Advanced Microscopic Analysis Digital Image Analysis Core lists: Indiana O'Brien Center for Advanced Microscopic Analysis Education Core lists: Indiana O'Brien Center for Advanced Microscopic Analysis Intravital Microscopy Core lists: Indiana O'Brien Center for Advanced Microscopic Analysis Probe Delivery Core lists: Indiana O'Brien Center for Advanced Microscopic Analysis lists: Indiana University Cooperative Center of Excellence in Hematology Angiogenesis Core lists: Indiana University Cooperative Center of Excellence in Hematology Experimental Mouse Resources Core lists: Indiana University School of Medicine Flow Cytometry Core Facility lists: Indiana University Cooperative Center of Excellence in Hematology Optical Microscopy Core lists: Indiana University Cooperative Center of Excellence in Hematology lists: Johns Hopkins University - University of Maryland Diabetes Research Center Administrative Core lists: Johns Hopkins University - University of Maryland Diabetes Research Center Cell Biology Core lists: Johns Hopkins University - University of Maryland Diabetes Research Center Gene Editing Core lists: Johns Hopkins University - University of Maryland Diabetes Research Center Health and Populations Science Core lists: Johns Hopkins University - University of Maryland Diabetes Research Center Integrated Physiology Core lists: Johns Hopkins University - University of Maryland Diabetes Research Center Molecular and Translational Genomics Core lists: Johns Hopkins University - University of Maryland Diabetes Research Center lists: Joslin Diabetes Center Advanced Genomics and Genetics Core Facility lists: Joslin Diabetes Center Advanced Microscopy Core Facility lists: Joslin Diabetes Center Animal Physiology Core Facility lists: Joslin Diabetes Center Bioinformatics and Biostatistics Core lists: Joslin Diabetes Center Enrichment Core lists: Joslin Diabetes Center Flow Cytometry Core Facility lists: Joslin Diabetes Center Induced Pluripotent Stem Cell Core lists: Joslin Diabetes Center lists: Marion Bessin Liver Research Center Animal Models Stem Cells and Cell Therapy lists: Marion Bessin Liver Research Center Genetic Engineering and Gene Therapy lists: Marion Bessin Liver Research Center Imaging and Cell Structure lists: Marion Bessin Liver Research Center lists: Mayo Clinic Center for Cell Signaling in Gastroenterology Clinical Core lists: Mayo Clinic Center for Cell Signaling in Gastroenterology Gene Editing and Cell Engineering Core lists: Mayo Clinic Center for Cell Signaling in Gastroenterology Optical Microscopy Core lists: Mayo Clinic Center for Cell Signaling in Gastroenterology lists: Mayo Clinic O'Brien Urology Center Biostatistics and Epidemiology Core lists: Mayo Clinic O'Brien Urology Center Imaging Core lists: Mayo Clinic O'Brien Urology Center lists: Mayo Clinic O'Brien Urology Center Urine Phenotyping Core lists: Michigan Center for Diabetes Translational Research Administrative Core Facility 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Fibrosis Vector Core Facility lists: University of Washington Diabetes Research Center Administrative Core lists: University of Washington Diabetes Research Center Cell Function Analysis Core Facility lists: University of Washington Diabetes Research Center Cellular and Molecular Imaging Core lists: University of Washington Diabetes Research Center Human Studies Core Facility lists: University of Washington Diabetes Research Center Quantitative and Functional Proteomics Core Facility lists: University of Washington Diabetes Research Center lists: University of Washington Diabetes Research Center Vector and Transgenic Mouse Core lists: Vanderbilt Diabetes Research and Training Center Cell Imaging Shared Resource Core Facility lists: Vanderbilt Diabetes Research and Training Center Hormone Assay and Analytical Services Core Facility lists: Vanderbilt Diabetes Research and Training Center Islet Procurement and Analysis Core lists: Vanderbilt Diabetes Research and Training Center Metabolic 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Indian/Alaskan Native Communities Core lists: Washington University Center for Diabetes Translation Research lists: USC Liver Transplant Program and Center for Liver Disease Cell Separation and Culture Core lists: Washington University Center for Diabetes Translation Research Solutions to Diabetes in Black Americans Core lists: Washington University Digestive Diseases Research Core Center Administrative and Resource Access Core lists: USC Liver Transplant Program and Center for Liver Disease Liver Histology Core lists: USC Liver Transplant Program and Center for Liver Disease lists: Vanderbilt Center for Diabetes Translation Research Administrative Core lists: Vanderbilt Center for Diabetes Translation Research Behavioral Intervention Technologies and Services Core lists: Vanderbilt Center for Diabetes Translation Research Community Engagement Core lists: Vanderbilt Center for Diabetes Translation Research Community Outreach and Heath Disparities Core lists: Vanderbilt Center for Diabetes Translation Research lists: Washington University Digestive Diseases Research Core Center Advanced Imaging and Tissue Analysis Core lists: Vanderbilt Center for Diabetes Translation Research Translation Methods Core lists: Washington University Digestive Diseases Research Core Center Biobank Core lists: Yale Liver Center lists: Washington University Digestive Diseases Research Core Center Murine Models and Gnotobiotics Core lists: Yale Liver Center Morphology Core lists: Washington University Digestive Diseases Research Core Center lists: Yale Liver Center Clinical and Translational Core lists: Washington University School of Medicine Diabetes Research Center Cell and Tissue Imaging Core lists: Yale Liver Center Cellular and Molecular Physiology Core lists: Washington University School of Medicine Diabetes Research Center Diabetes Models Phenotyping Core Facility lists: Yale Liver Center Administrative Core lists: Washington University School of Medicine Diabetes Research Center Translational Diagnostics Core lists: Yale Diabetes Research Center lists: Washington University School of Medicine Diabetes Research Center Immunology of Type 1 Diabetes Core lists: Yale Diabetes Research Center Physiology Core Facility lists: Washington University School of Medicine Diabetes Research Center Mass Spectrometry Core lists: Yale Diabetes Research Center Molecular Genetics Core lists: Yale Diabetes Research Center Molecular Core Facility lists: Washington University School of Medicine Diabetes Research Center Morphology and Metabolic Analysis Core lists: Yale Diabetes Research Center Diabetes Translational Core Facility lists: Washington University School of Medicine Diabetes Research Center lists: Washington University School of Medicine Diabetes Research Center Transgenic and ES Cell Core lists: Yale Diabetes Research Center Clinical Metabolism Core Facility lists: Yale Diabetes Research Center Cell Biology Core Facility lists: Washington University St. Louis Nutrition Obesity Research Center lists: Yale Diabetes Research Center Administrative Core Facility lists: Yale Cooperative Center of Excellence in Hematology Animal Modeling Core lists: Yale Cooperative Center of Excellence in Hematology lists: Yale Cooperative Center of Excellence in Hematology Cell Preparation and Analysis Core lists: Yale Cooperative Center of Excellence in Hematology Imaging Core lists: Harvard Digestive Disease Center lists: Harvard Digestive Diseases Center Biomedical CORE B: Microscopy and Histopathology lists: Harvard Digestive Diseases Center Biomedical CORE C: Epithelial Cell and Mucosal Immunology lists: Harvard Digestive Diseases Center Biomedical CORE D: Gnotobiotic Mice, Microbiology and Metagenomics lists: Harvard Digestive Diseases Center Clinical Translational Research Program lists: Harvard Digestive Diseases Center Bio-Repository and Data Registry for Human Material lists: Hopkins Conte Digestive Diseases Basic and Translational Research Core Center 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Liver Diseases Cell Culture Core lists: Joslin Diabetes Center Molecular Phenotyping and Genotyping Core lists: University of Pennsylvania Diabetes Research Center lists: Preventing Early Renal Loss in Diabetes (PERL) lists: Clinical Trials in Organ Transplantation in Children (CTOT-C) lists: Clinical Trials in Organ Transplantation (CTOT) lists: Stanford Diabetes Research Center lists: Monogenic Diabetes Registry lists: Chronic Prostatitis Collaborative Research Network Clinical Trial- Alfuzosin lists: National Glycohemoglobin Standardization Program lists: MetaCyto lists: JOINSOLVER lists: HASP lists: NetCirChro lists: Simmune lists: ABC Bacterial Transporter Systems Database lists: Kidney Precision Medicine Project lists: ValIdated Systematic IntegratiON of epigenomic data lists: The Human BioMolecular Atlas Program lists: Prevention of Lower Urinary Tract Symptoms lists: Illuminating the Druggable Genome lists: 4D Nucleome lists: immuneXpresso lists: Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain lists: Secrepedia lists: MoTrPAC Data Hub lists: Human Cell Atlas lists: PANC-DB lists: Rare and Atypical Diabetes Network lists: Diabetes Control and Complications Trial lists: Diabetes Data and Hypothesis Hub lists: Common Metabolic Diseases Knowledge Portal lists: Type 1 Diabetes Knowledge Portal lists: Sleep Disorder Knowledge Portal lists: Cardiovascular Disease Knowledge Portal lists: Cerebrovascular Disease Knowledge Portal lists: Trans-Omics for Precision Medicine (TOPMed) Program lists: All of Us lists: AI-READI is listed by: NIH Data Sharing Repositories is listed by: NIDDK Research Resources is listed by: Collaborating for the Advancement of Interdisciplinary Research in Benign Urology is related to: MTOPS Prostate Samples Analysis Consortium is related to: Neuroscience Information Framework is related to: Diabetes Disease Portal is related to: Kidney and Urinary Pathway Knowledge Base is related to: dbMHC is related to: Islet Cell Resource Centers is related to: DGAP is related to: Nuclear Receptor Resource is related to: dkCOIN is related to: Human Biological Data Interchange is related to: National Gene Vector Biorepository is related to: Creatinine Standardization Program is related to: Glomerular Filtration Rate Calculators is related to: Congressionally Directed Medical Research Program is related to: National Kidney Disease Education Program is related to: Network of Minority Health Research Investigators is related to: National Endocrine and Metabolic Diseases Information Service is related to: Kidney and Urinary Pathway Ontology is related to: National Diabetes Information Clearinghouse is related to: Digestive Diseases Statistics for the United States is related to: Diabetes in America is related to: National Digestive Diseases Information Clearinghouse is related to: Diabetes Control and Complications Trial is related to: National Hematologic Diseases Information Service is related to: National Kidney and Urologic Diseases Information Clearinghouse is related to: Nonhuman Primate Transplantation Tolerance Cooperative Study Group is related to: Type 1 Diabetes Preclinical Testing Program is related to: Diabetes Autoantibody Standardization Program is related to: AASK Clinical Trial and Cohort Study is related to: Maryland Genetics of Interstitial Cystitis is related to: Frequent Hemodialysis Network Nocturnal Trial is related to: Mammalian Gene Collection is related to: Zebrafish Gene Collection is related to: Boston Area Community Health Survey is related to: Minimally Invasive Surgical Therapies Treatment Consortium for Benign Prostatic Hyperplasia is related to: Focal Segmental Glomerulosclerosis in Children and Young Adults Interventional Study is related to: Complementary and Alternative Medicine for Urological Symptoms is related to: Mouse Mutagenesis Center for Developmental Defects is related to: CARDS Database is related to: ACCORD is related to: Program to Reduce Incontinence by Diet and Exercise is related to: Renal Disease Portal is related to: Renin Angiotensin System Study is related to: NIH Data Sharing Repositories is related to: Kidney Development Database is related to: GenePaint Interactive Anatomy Atlas is related to: EMAGE Gene Expression Database is related to: Gene Expression Omnibus is related to: MGnify is related to: FAIR Data Informatics Laboratory is related to: Type 1 Diabetes Knowledge Portal is related to: Polycystic Kidney Disease Research Resource Consortium has parent organization: SciCrunch has parent organization: University of California at San Diego; California; USA
|
Digestive disease, Kidney disease, Diabetes, Metabolic disease, Endocrine disease, Obesity, Urologic disease, Type 1 diabetes, Type 2 diabetes |
NIDDK U24 DK097771 |
PMID:26393351 |
Free, Freely available |
|
nlx_153866, r3d100012845 |
http://scicrunch.org/dknet, https://doi.org/10.17616/R31NJMEL |
|
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SCR_001606 |
National Institute of Diabetes and Digestive and Kidney Disease Information Network, NIDDK Information Network, DKnet, NIDDKInformation Network |
2026-08-11 09:40:24 |
21 |
Renin Angiotensin System Study
Resource Report
Resource Website
1+ mentions
|
Renin Angiotensin System Study (RRID:SCR_013385)
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RASS/B-RASS, RASS
|
clinical trial, resource
|
Randomized, multicenter, double-blind study to determine if renin angiotensin medications, either losartan (angiotensin II blocker) or enalapril (converting enzyme inhibitor), can prevent or delay the onset of diabetic kidney disease in patients with type 1 diabetic patients who do not have hypertension, diabetic nephropathy, or predictive levels of microalbuminuria. Two hundred eight five patients ages 16-61 with 2-20 yrs of Type 1 Diabetes Mellitus and no renal functional abnormalities were randomized into a parallel, double-blind, placebo-controlled study involving 3 groups (95 patients/group). Each group received an angiotensin-converting enzyme inhibitor (ACEI) (enalapril), or an angiotensin II receptor blocker (Losartan), or placebo. All patients had their usual Diabetes Mellitus (DM) management. Baseline studies included measures of glomerular filtration rate (GFR), urinary albumin excretion rate (UAE), blood pressure (BP), and a percutaneous renal biopsy. Patients were followed by quarterly measures of BP, HbA1C, UAE, and drug compliance. There were annual measures of GFR and a repeat renal biopsy after 5 yrs in the study. The main endpoint is kidney structural changes over time, especially mesangial fractional volume (v(Mes/glom)). Secondary endpoints will be other DN structural measures and measures of kidney function (UAE, GFR). These studies will determine whether rennin angiotensin system blockage in the early stages of DN can prevent the early kidney structural changes in this important disorder. Ancillary studies will evaluate the effects of treatment group on the development and progression of diabetic retinopathy and will develop predictors of study participants'''' compliance. Baseline, 2.5 and 5 year retinal fundus photographs in the RASS patients were obtained.
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enalapril, drug, losartan, angiotensin, medication, kidney, intervention, clinical, adolescent, adult human, renal biopsy, renin-angiotensin system, diabetic nephropathy, kidney, placebo, glomerular filtration rate, urinary albumin excretion rate, blood pressure
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is related to: NIDDK Information Network (dkNET) has parent organization: ClinicalTrials.gov has parent organization: University of Minnesota Twin Cities; Minnesota; USA
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Type 1 diabetes, Diabetic kidney disease, Retinopathy, Nephropathy, Diabetes |
NIDDK |
PMID:19571282 |
|
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nlx_152849 |
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SCR_013385 |
Renin Angiotensin System Blockage-DN (RASS), Renin Angiotensin System Study (RASS/B-RASS) |
2026-08-11 09:42:42 |
1 |
Family Investigation of Nephropathy of Diabetes
Resource Report
Resource Website
|
Family Investigation of Nephropathy of Diabetes (RRID:SCR_001525)
|
FIND, F.I.N.D.
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clinical trial, resource
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Multicenter observational study designed to identify genetic determinants of diabetic nephropathy. It is conducted in eleven U.S. clinical centers and a coordinating center, and with four ethnic groups (European Americans, African Americans, Mexican Americans, and American Indians). Two strategies are used to localize susceptibility genes: a family-based linkage study and a case-control study using mapping by admixture linkage disequilibrium (MALD). In the family-based study, probands with diabetic nephropathy are recruited with their parents and selected siblings. Linkage analyses will be conducted to identify chromosomal regions containing genes that influence the development of diabetic nephropathy or related quantitative traits such as serum creatinine concentration, urinary albumin excretion, and plasma glucose concentrations. Regions showing evidence of linkage will be examined further with both genetic linkage and association studies to identify genes that influence diabetic nephropathy or related traits. Two types of MALD studies are being done. One is a case-control study of unrelated individuals of Mexican American heritage in which both cases and controls have diabetes, but only the case has nephropathy. The other is a case-control study of African American patients with nephropathy (cases) and their spouses (controls) unaffected by diabetes and nephropathy; offspring are genotyped when available to provide haplotype data. The specific goals of this program: * Delineate genomic regions associated with the development and progression of renal disease(s) * Evaluate whether there is a genetic link between diabetic nephropathy and diabetic retinopathy * Improve outcomes * Provide protection for people at risk and slow the progression of renal disease * Help establish a resource for genetic studies of kidney disease and diabetic complications by creating a repository of genetic samples and a database * Encourage studies of the genetics of progressive renal disease
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genetic susceptibility, genetic pathway, renal, kidney, outcome, gene, genetics, european-american, african-american, mexican-american, american-indian, linkage association study, admixture linkage disequilibrium, mapping by admixture linkage disequilibrium, serum creatinine, urinary protein excretion, plasma glucose level, blood pressure, blood lipid level, trait, linkage, adult human, male, female, clinical
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is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
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NIDDK 5R01DK053591 |
PMID:15642484 |
Free, Freely available |
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nlx_152825 |
https://www.niddkrepository.org/studies/find/ |
|
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SCR_001525 |
Family Investigation of Nephropathy and Diabetes (F.I.N.D.), Family Investigation of Nephropathy & Diabetes |
2026-08-11 09:40:22 |
0 |
RiVuR
Resource Report
Resource Website
1+ mentions
|
RiVuR (RRID:SCR_001539)
|
RIVUR
|
clinical trial, resource
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Multicenter, randomized, double-blind, placebo-controlled trial is designed to determine whether daily antimicrobial prophylaxis is superior to placebo in preventing recurrence of urinary tract infection (UTI) in children with vesicoureteral reflux (VUR). The basic eligibility criteria are: (1) age at randomization of at least 2 months, but less than 6 years, (2) a diagnosed first febrile or symptomatic UTI within 42 days prior to randomization that was appropriately treated, and (3) presence of Grade I-IV VUR based on voiding cystourethrogram (VCUG). Patients will be randomly assigned to treatment for 2 years with daily antimicrobial prophylaxis (trimethoprim-sulfamethoxazole) or placebo. The study is designed to recruit 600 children (approximately 300 in each treatment group) over an 18-24 month period. The primary endpoint is recurrence of UTI. In addition, patients will be evaluated for secondary endpoints related to renal scarring and antimicrobial resistance. Scarring will be determined based on renal scintigraphy by 99mTc dimercaptosuccinic (DMSA) scan. Quality of life, compliance, safety parameters, utilization of health resources, and change in VUR will be assessed periodically throughout the study.
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child, antimicrobial prophylaxis, placebo, antibiotic, renal scarring, pediatric, trimethoprim-sulfamethoxazole, intervention, kidney, antibiotic resistance, young human, infant, bibliography, clinical, trimethoprim, sulfamethoxazole
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is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Research Resources has parent organization: University of North Carolina at Chapel Hill; North Carolina; USA
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Vesico-ureteral reflux, Urinary tract infection |
NIDDK |
PMID:19570724 PMID:19018048 PMID:18076937 PMID:19018047 PMID:19086141 |
Free, Freely available |
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nlx_152848 |
http://www.cscc.unc.edu/rivur/ |
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SCR_001539 |
Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR), Randomized Intervention for Children with Vesicoureteral Reflux, Randomized Intervention for Vesicoureteral Reflux |
2026-08-11 09:40:22 |
1 |
Folic Acid for Vascular Outcome Reduction in Transplantation
Resource Report
Resource Website
1+ mentions
|
Folic Acid for Vascular Outcome Reduction in Transplantation (RRID:SCR_001505)
|
FAVORIT
|
clinical trial, resource
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Multi-center, randomized, double blind controlled clinical trial to determine whether treatment with a standard multivitamin augmented with high doses of folic acid, vitamin B6 and vitamin B12 reduces the rate of cardiovascular disease outcomes in renal transplant recipients relative to participants receiving a similar multivitamin that contains no folic acid. This study hopes to show that by reducing the level of homocysteine in the body, the risk of heart disease is also reduced among kidney transplant patients.
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multivitamin, folic acid, vitamin b6, vitamin b12, outcome, homocysteine, adult human, middle adult human, late adult human, vitamin, bibliography
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is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) has parent organization: University of North Carolina at Chapel Hill; North Carolina; USA
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Cardiovascular disease, Kidney transplant recipient |
NIDDK U01DK061700 |
PMID:16923411 |
Free, Freely available |
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nlx_152827 |
http://www.cscc.unc.edu/favorit/ |
http://www.cscc.unc.edu/favorit/favdescrip.htm |
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SCR_001505 |
Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) |
2026-08-11 09:40:22 |
1 |
Diabetes Control and Complications Trial
Resource Report
Resource Website
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Diabetes Control and Complications Trial (RRID:SCR_006805)
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DCCT
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data or information resource, clinical trial, resource, database
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Clinical study that showed that keeping blood glucose levels as close to normal as possible slows the onset and progression of eye, kidney, and nerve diseases caused by diabetes. EDIC is a follow-up study of people who participated in DCCT. The DCCT involved 1,441 volunteers, ages 13 to 39, with type 1 diabetes and 29 medical centers in the United States and Canada. Volunteers had to have had diabetes for at least 1 year but no longer than 15 years. They also were required to have no, or only early signs of, diabetic eye disease. The study compared the effects of standard control of blood glucose versus intensive control on the complications of diabetes. Intensive control meant keeping hemoglobin A1C levels as close as possible to the normal value of 6 percent or less. The A1C blood test reflects a person''''s average blood glucose over the last 2 to 3 months. Volunteers were randomly assigned to each treatment group. DCCT Study Findings * Intensive blood glucose control reduces risk of ** eye disease: 76% reduced risk ** kidney disease: 50% reduced risk ** nerve disease: 60% reduced risk When the DCCT ended, researchers continued to study more than 90 percent of participants. The follow-up study, called Epidemiology of Diabetes Interventions and Complications (EDIC), is assessing the incidence and predictors of cardiovascular disease events such as heart attack, stroke, or needed heart surgery, as well as diabetic complications related to the eye, kidney, and nerves. The EDIC study is also examining the impact of intensive control versus standard control on quality of life. Another objective is to look at the cost-effectiveness of intensive control. EDIC Study Findings * Intensive blood glucose control reduces risk of ** any cardiovascular disease event: 42% reduced risk ** nonfatal heart attack, stroke, or death from cardiovascular causes: 57% reduced risk
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blood glucose, adolescent, young human, middle adult human, longitudinal, eye disease, kidney disease, nerve disease, cardiovascular disease, heart attack, stroke, blood pressure, blood lipid, complication
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is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Central Repository is related to: Epidemiology of Diabetes Interventions and Complications is related to: Epidemiology of Diabetes Interventions and Complications is related to: NIDDK Information Network (dkNET) has parent organization: National Diabetes Information Clearinghouse
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Type 1 diabetes, Diabetes |
NIDDK |
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nlx_152798 |
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SCR_006805 |
DCCT and EDIC: The Diabetes Control and Complications Trial and Follow-up Study |
2026-08-11 09:41:27 |
0 |
Focal Segmental Glomerulosclerosis in Children and Young Adults Interventional Study
Resource Report
Resource Website
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Focal Segmental Glomerulosclerosis in Children and Young Adults Interventional Study (RRID:SCR_007130)
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FSGS in Children and Young Adults Interventional Study
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clinical trial, resource
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Network of collaborative research centers that tested the effects of treatment with cyclosporine to treatment with mycophenalate mofetil combined with oral pulse dexamethasone in children and young adults with focal segemental glomerulosclerosis. Efficacy was assessed in terms of induction of remission of proteinuria after 52 weeks of treatment and sustained remission after 26 weeks off treatment. The clinical sites were State University of New York, Stony Brook; Montefiore Medical Center; Seattle Children''''s Medical Center; Medical City Dallas Hospital; and the University of North Carolina. The Cleveland Clinic is the data-coordinating center, and NephCure will fund ancillary studies.
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child, early adult, young human, proteinuria, kidney disease, intervention, prednisone, cyclosporine, mycophenalate mofetil, dexamethasone, cyclosporine-a, male, female
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is listed by: ClinicalTrials.gov is affiliated with: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases is related to: NIDDK Information Network (dkNET) has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
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Focal Segmental Glomerulosclerosis, Focal Segmental Glomerulosclerosis Nephrotic Syndrome |
NIDDK |
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nlx_152826 |
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http://www.fsgstrial.org |
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SCR_007130 |
Focal Segmental Glomerulosclerosis Clinical Trial, Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT), Focal Segmental Glomerulosclerosis (FSGS) Clinical Trial, Focal Segmental Glomerulosclerosis (FSGS) in Children and Young Adults Interventional Study |
2026-08-11 09:41:31 |
0 |
Minimally Invasive Surgical Therapies Treatment Consortium for Benign Prostatic Hyperplasia
Resource Report
Resource Website
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Minimally Invasive Surgical Therapies Treatment Consortium for Benign Prostatic Hyperplasia (RRID:SCR_007126)
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MIST for BPH
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clinical trial, resource
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Randomized clinical trial to determine the efficacy and safety of three treatments for benign prostatic hyperplasia (BPH): transurethral needle ablation (TUNA), transurethral microwave therapy (TUMT), and medical therapy with alfuzosin and finasteride. The study has been terminated. (Inability to recruit required sample size.)
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transurethral microwave thermotherapy, transurethral needle ablation, therapy, drug, finasteride, alfuzosin, treatment, clinical, intervention, male, middle adult human, late adult human, prostate
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is listed by: ClinicalTrials.gov is related to: NIDDK Information Network (dkNET) has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
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Benign Prostatic Hyperplasia |
NIDDK |
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nlx_152844 |
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SCR_007126 |
Minimally Invasive Surgical Therapies (MIST) Treatment Consortium for Benign Prostatic Hyperplasia (BPH), Minimally Invasive Surgical Therapy Consortium for Benign Prostatic Hyperplasia |
2026-08-11 09:41:30 |
0 |