Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.
URL: http://clinicaltrials.gov/show/NCT00059202
Proper Citation: High-dose Ursodiol Therapy of Primary Sclerosing Cholangitis (RRID:SCR_006772)
Description: Multi-center, placebo-controlled trial of ursodiol in primary sclerosing cholangitis (PSC). A total of 150 patients with previously untreated PSC without cirrhosis were randomly assigned to receive high doses of ursodiol (20-25 mg/kg/day) or placebo for two years. Patients underwent medical evaluation, endoscopic retrograde cholangiography, and liver biopsy before randomization and again at two-year intervals. The endpoints of therapy were progression of hepatic fibrosis, liver decompensation, liver transplantation, or death. The treatment phase of the study was stopped for futility in June 2008; however, patients continue to be followed. Ongoing mechanistic studies are underway.
Abbreviations: HUSC
Synonyms: Trial of High-dose Urso in Primary Sclerosing Cholangitis, High-dose Ursodiol Therapy of Primary Sclerosing Cholangitis (HUSC), Multicentered Randomized Trial of High-dose Urso in Primary Sclerosing Cholangitis
Resource Type: resource, clinical trial
Defining Citation: PMID:19585548
Keywords: treatment, placebo, ursodeoxycholic acid, intervention, randomized, adult human, male, female
Expand Allis listed by |
|
is listed by |
|
has parent organization |
We found {{ ctrl2.mentions.total_count }} mentions in open access literature.
We have not found any literature mentions for this resource.
We are searching literature mentions for this resource.
Most recent articles:
{{ mention._source.dc.creators[0].familyName }} {{ mention._source.dc.creators[0].initials }}, et al. ({{ mention._source.dc.publicationYear }}) {{ mention._source.dc.title }} {{ mention._source.dc.publishers[0].name }}, {{ mention._source.dc.publishers[0].volume }}({{ mention._source.dc.publishers[0].issue }}), {{ mention._source.dc.publishers[0].pagination }}. (PMID:{{ mention._id.replace('PMID:', '') }})
A list of researchers who have used the resource and an author search tool
A list of researchers who have used the resource and an author search tool. This is available for resources that have literature mentions.
No rating or validation information has been found for High-dose Ursodiol Therapy of Primary Sclerosing Cholangitis .
No alerts have been found for High-dose Ursodiol Therapy of Primary Sclerosing Cholangitis .
Source: SciCrunch Registry