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Treatment Options for type 2 Diabetes in Adolescents and Youth (RRID:SCR_001547)Copy Citation Copied
Proper Citation: Treatment Options for type 2 Diabetes in Adolescents and Youth (RRID:SCR_001547)
Description: Randomized, double blind, nationwide clinical trial to compare the efficacy and safety of three interventions to treat adolescents and youth with type 2 diabetes (T2D): (1) metformin alone, (2) metformin plus rosiglitazone, and (3) metformin plus an intensive lifestyle intervention called the TODAY Lifestyle Program (TLP). The secondary aims are to: compare and evaluate the safety of the three treatment arms; compare the effects of the three treatments on the pathophysiology of type 2 diabetes (T2D) with regards to beta cell function and insulin resistance, body composition, nutrition, physical activity and aerobic fitness, cardiovascular risk factors, microvascular complications, quality of life, and psychological outcomes; evaluate the influence of individual and family behaviors on treatment response; and compare the relative cost effectiveness of the three treatment arms. The study recruits patients over a three-year period and follows patients for a minimum of two years. Patients are randomized within two years of the diagnosis of T2D. Materials that were used for the study are made publicly available: * The TODAY Standard Diabetes Education (TSDE) program, developed especially for youth with type 2 diabetes. (All participants received the TSDE program) * The TODAY Lifestyle Program (TLP) that was among the treatments tested.
Abbreviations: TODAY
Synonyms: Treatment Options for type 2 Diabetes in Adolescents & Youth, TODAY study
Resource Type: resource, clinical trial, data or information resource, narrative resource, training material
Defining Citation: PMID:20962021, PMID:17448130, PMID:19823189
Keywords: adolescent, child, young human, glycemic control, metformin, drug, rosiglitazone behavior, lifestyle program, lifestyle change, intervention, treatment, safety, efficacy, male, female, experimental protocol, bibliography
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The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant 2U24DK097771-09.
Email: info_at_ dknet.org
