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Signaling Pathways Project (SPP): A multi-omics knowledgebase for cellular signaling pathways

WHAT IS IT?

Signaling Pathways Project (SPP) is a FAIR data knowledgebase that allows researchers to ask questions across thousands of annotated transcriptomic and ChIP-Seq datasets. Its powerful consensome meta-analysis pipeline allows researchers to make high-confidence connections between transcriptonal targets, their upstream regulatory pathways, and disease states.


WHO CAN USE IT?

Any researcher who is interested in identifying transcriptional targets for receptors, enzymes and transcription factors. SPP is designed specifically for bench scientists and no computer programming skills are required to use it.


WHAT TYPE OF QUESTIONS CAN IT ANSWER?

1. What cell cycle genes are regulated by FGF receptors in human liver?
2. What human genes are most responsive to insulin receptor signaling?
3. What genes in my gene set are regulated by E3 ubiquitin ligases?

STORIES OF DISCOVERY

The Signaling Pathways Project Brings New Insight into COVID-19 Research

Based on evidence found using SPP, researchers hypothesized that the suppression of the interferon response to SARS2 infection by elevated...[more]


SEARCH FOR A LIST OF DATASETS THAT SPP INCORPORATES


SEARCH FOR GENES WITH IMPORTANT ROLES IN DK-RELEVANT RECEPTORS, ENZYMES, ORGANS AND TISSUES USING OUR *CONSENSOME APPROACH:


*Consensomes are list of genes ranked according to a meta-analysis of their differential expression in publicly archived transcriptomic datasets involving perturbations of a specific signaling pathway in a given biosample category. Consensome are intended as a guide to identifying those genes most consistently impacted by a given pathway in a given tissue context.