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NIDDK Data or Sample Repositories
NIDDK Project-specific or consortium-specific data or sample repositories
The list provided here are NIDDK Project-specific or consortium-specific data or sample repositories. These repositories usually accept data or samples from project team or collaborators only. For a more complete listing of available NIDDK data or sample repositories, please visit NIDDK Central Repository.
For a list of data repositories that are opened to researchers and recommended by the following sources: NIDDK domain experts, Nature Scientific Data, PlosOne, NLM NIH Data Sharing Repositories, and Science. Please visit dkNET Suggested Data Repositories page.
Division of Kidney, Urologic, and Hematologic Diseases (KUH)
Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM)
Division of Digestive Diseases and Nutrition (DDN)
KUH Basic Studies
| Resource Name | RRID | Description | Data Deposition | Data Sharing | Data/Resource Access Points |
|---|---|---|---|---|---|
| CKD Biomarkers Consortium (CKD BioCon) | RRID:SCR_014381 | The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) established the CKD Biomarkers Consortium (BioCon) to promote the discovery and validation of biomarkers to advance the field of chronic kidney disease (CKD) research. | project team only | via public repositories | no specimens available |
| Genitourinary Development Molecular Anatomy Project (GUDMAP) | RRID:SCR_001554 | The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) is a consortium of laboratories working to provide the scientific and medical community with tools to facilitate research on the GenitoUrinary (GU) tract. | project team only | via coordinating center | to access data |
| Kidney Precision Medicine Project (KPMP) | RRID:SCR_016920 | The NIDDK Kidney Precision Medicine Project (KPMP) aims to ethically obtain and evaluate human kidney biopsies from participants with Acute Kidney Injury (AKI) or Chronic Kidney Disease (CKD), create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways, and targets for novel therapies. | project team only | via coordinating center | TBD |
| Nephromine | RRID:SCR_003813 | ||||
| (Re)Building a Kidney (RBK) | RRID:SCR_014442 | (Re)Building a Kidney is an NIDDK-funded consortium of research projects working to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types and their integration into complex structures that replicate human kidney function. | project team only | via coordinating center | to access data |
| Validated Systematic integration (VISION) of epigenetic data | RRID:SCR_016921 | ValIdated Systematic IntegratiON (VISION) of epigenetic data to analyze mouse and human hematopoiesis, a tractable system with clear clinical significance and importance to NIDDK. | project team only | via coordinating center | TBD |
KUH Partnerships with trans-NIH
| Resource Name | RRID | Description | Data Deposition | Data Sharing | Data/Resource Access Points |
|---|---|---|---|---|---|
| Nephromine.org | RRID:SCR_003813 | ||||
| Nephrotic Syndrome Study Network (NEPTUNE) | RRID:SCR_014380 | We are an integrated group of academic medical centers, patient support organizations, and clinical research resources dedicated to advancing the understanding and treatment of Nephrotic Syndrome. | TBD | ||
| The Human BioMolecular Atlas Program (HuBMAP) | RRID:SCR_016922 | The Human BioMolecular Atlas Program (HuBMAP) aims to facilitate research on single cells within tissues by supporting data generation and technology development to explore the relationship between cellular organization and function, as well as variability in normal tissue organization at the level of individual cells. | project team only | via coordinating center | TBD |
KUH Clinical Studies & Trials
| Resource Name | RRID | Description | Data Deposition | Data Sharing | Data/Resource Access Points |
|---|---|---|---|---|---|
| Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) | RRID:SCR_014386 | The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) Study investigates differences in the occurrence of renal and cardiovascular outcomes and death within a diverse, matched cohort of patients with and without acute kidney injury (AKI). | project team only | NIDDK central repository | to access specimens |
| Chronic Renal Insufficiency Cohort (CRIC) | RRID:SCR_009016 | The Chronic Renal Insufficiency Cohort (CRIC) Study is an observational study that examined risk factors for progression of chronic renal insufficiency (CRI) and cardiovascular disease (CVD) among CRI patients. | project team only | NIDDK central repository | to access specimens & data |
| Chronic Kidney Disease in Children (CKiD) | RRID:SCR_001500 | The CKiD Study is a NIH-funded, multicenter, prospective cohort study of children aged 6 months to 16 years with mild to moderate impaired kidney function. The primary goals of CKiD are to determine the risk factors for decline in renal function and to define how progressive decline in renal function impacts biomarkers of risk factors for cardiovascular disease; neurocognitive function and behavior; and growth failure and its associated morbidity. | project team only | NIDDK central repository | to access specimens & data |
| Complementary and Alternative Medicine for Urological Symptoms (CAMUS) | RRID:SCR_007131 | The Complementary and Alternative Medicine for Urological Symptoms (CAMUS) study was a double-blind, placebo-controlled randomized clinical trial that investigated the efficacy of a widely available phytotherapy, saw palmetto extract, at up to 3 times the standard dose on lower urinary tract symptoms attributed to benign prostatic hyperplasia (BPH) in men. | project team only | NIDDK central repository | to access specimens & data |
| Comprehensive Dialysis Study (CDS) | The Comprehensive Dialysis Study (CDS) is a special data collection study in which physical activity, health-related quality of life, and work/disability data were requested from patients identified as initiating maintenance dialysis during 2005 to 2007. | project team only | NIDDK central repository | to access specimens & data | |
| Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) | RRID:SCR_000690 | The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) was established to develop and implement studies to test whether imaging techniques can provide accurate and reproducible markers of progression of renal disease in patients with polycystic kidney disease. | project team only | NIDDK central repository | to access specimens & data |
| Dialysis Access Consortium (Graft & Fistula) | The Dialysis Access Consortium (DAC) is an NIDDK-funded multi-center consortium that was developed to investigate interventions to improve hemodialysis vascular access outcomes in patients with end-stage renal disease (ESRD). | project team only | NIDDK central repository | to access specimens & data | |
| Family Investigation of Nephropathy and Diabetes (FIND) | RRID:SCR_001525 | The Family Investigation of Nephropathy and Diabetes (FIND) was a multicenter observational study designed to identify genetic determinants of diabetic kidney disease. Study subjects were recruited from eleven centers and in many ethnic groups throughout the United States for a genome-wide association study (GWAS). | project team only | NIDDK central repository | to access specimens & data |
| Focal Segmental Glomerulosclerosis (FSGS/FONT) | RRID:SCR_007130 | The FSGS Clinical Trial (FSGS-CT) was a multi-center, prospective, controlled, open label randomized trial designed to determine if treatment with mycophenolate mofetil (MMF) in conjunction with pulse steroids is superior to treatment with Cyclosporine-A (CSA) in inducing remission from proteinuria over 12 months. | project team only | NIDDK central repository | to access specimens & data |
| Genetics of Kidneys in Diabetes (GoKind) | RRID:SCR_000133 | The Genetics of Kidneys in Diabetes (GoKinD) study was an initiative that aimed to identify genes that are involved in diabetic nephropathy. A large number of individuals with type 1 diabetes were screened to identify two subsets, one with clear-cut kidney disease and another with normal renal status despite long-term diabetes. | project team only | NIDDK central repository | to access specimens & data |
| Hemodialysis Pilot Studies Consortium | The Hemodialysis Pilot Studies Consortium (HDPSC) will design and conduct pilot and feasibility studies of novel therapies to reduce morbidity and mortality for patients treated with maintenance hemodialysis. | project team only | NIDDK central repository | to access specimens & data | |
| Hemodialysis Study (HEMO) | The Hemodialysis (HEMO) Study was a multi-center, randomized clinical trial designed to test whether the mortality and morbidity of hemodialysis (HD) patients can be reduced by modifying the dialysis procedure for the removal of toxins from the blood. | project team only | NIDDK central repository | to access specimens & data | |
| Pilot Studies for candidate therapies… | project team only | via public repositories | |||
| Prevention of LUTS consortium | RRID:SCR_016923 | The PLUS Research Consortium aims to plan, perform and analyze the research studies that are needed to help researchers conduct future prevention and intervention studies for LUTS in women. | project team only | via public repositories |
DEM Basic Studies
| Resource Name | RRID | Description | Data Deposition | Data Sharing | Data/Resource Access Points |
|---|---|---|---|---|---|
| Chemoproteomic ID and therapeutic validatin of proteins of metabolic significance | RRID:SCR_015847 | This project combines expertise from multiple scientific fields (chemical proteomics, medicinal chemistry, adipose tissue and liver biology, lipid metabolism) to discover and characterize new molecular pathways that can be targeted pharmacologically to revert obesity-linked adipocyte defects that drive systemic insulin resistance and type 2 diabetes. | project team only | project website & dkNET | to access reagents |
| dkNET-Signaling Pathways Project (dkNET-SPP) | dkNET serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of the NIDDK. | project team only | via coordinating center | to access data | |
| Diabetes Interactive Database | The Genomic study of parental mice database allows you to search gene expression in 6 key tissues (islet, liver, adipose, hypothalamus, gastrocnemius and soleus) as a function of genetic obesity (lean vs. OB/OB), strain (B6 vs. BTBR), and age (4 vs. 10 weeks), in our mouse model of Type 2 diabetes. The Genetic study of F2 cohort database derives from the construction of ~500 B6:BTBR F2 mice that were all sacrificed at the same age (10 weeks) and were all obese, thereby focusing the study on genetic differences between the parental strains. The Collaborative Cross (CC) is a newly created panel of inbred mice that derives from 8 founder strains, including five classical lab strains (129S1/SvImJ, A/J, C57BL/6J, NOD/ShiLtJ, NZO/HILtJ) and three wild-derived strains (CAST/EiJ, PWK/PhJ and WSB/EiJ). | project team only | via webservices | to access data | |
| Epigenetic Drivers of Intrinsic Phenotypic Variability in Metabolic Disease | The purpose of this Catalyst project is to apply a highly innovative general theory that integrates evolution, developmental biology, and epigenetics, to metabolic disease and diabetes. Representing an entirely new area of my research, I will address directly the mechanistic basis for the high degree of variability in metabolism even in genetically identical individuals exposed to the same environment. This highly innovative proposal could have profound influence on our understanding of the developmental origins and associated variability in susceptibility to metabolic disease, with profound implications on future interventions using precision medicine paradigms. | project team only | TBD | TBD | |
| Human Islet Research Network - Antigen Receptor Database | Tool to enable searches of antigen receptor sequences associated with Type 1 Diabetes - cofunded by nPOD, JDRF and Helmsley | project team only | via coordinating center | to access data | |
| Human Islet Research Network-Human Pancreas Analysis Consortium (HIRN-HPAC) | RRID:SCR_016202 | The Human Pancreas Analysis Consortium (HPAC) is investigating the physical and functional organization of the human islet tissue environment, the cell-cell relationships within the pancreatic tissue ecosystem, and the contributions of non-endocrine components (acinar, ductal, vascular, perivascular, neuronal, lymphatic, immune) to islet cell function and dysfunction. | project team only | via coordinating center | to access data |
| Human Tissues and Organs for Research Resource Program (HTORR) | RRID:SCR_002859 | the HTORR program that NDRI provides biomedical investigators with donated normal and diseased human tissues and organs recovered from a diverse donor pool using customized procurement, processing, and preservation and distribution protocols. | project team only | via coordinating center | to access specimens |
| Integrated Islet Distribution Program (IIDP) | RRID:SCR_014387 | The IIDP provides high quality human islet distribution to the diabetes research community | project team only | via coordinating center | to access specimens & data |
| Mouse Metabolic Phenotyping Centers (MMPC) | RRID:SCR_008997 | The MMPC is a National Institutes of Health-sponsored resource that provides experimental testing services to scientists studying diabetes, obesity, diabetic complications, and other metabolic diseases in mice. | project team only | via coordinating center | to access data |
DEM Partnerships with trans-NIH
| Resource Name | RRID | Description | Data Deposition | Data Sharing | Data/Resource Access Points |
|---|---|---|---|---|---|
| 4D Nucleome | RRID:SCR_016925 | The Common Fund’s 4D Nucleome program aims to understand the principles underlying nuclear organization in space and time, the role nuclear organization plays in gene expression and cellular function, and how changes in nuclear organization affect normal development as well as various diseases. | project team | via coordinating center | to access data |
| AMP T2D | RRID:SCR_003743 | The T2D Knowledge Portal enables browsing, searching, and analysis of human genetic information linnked to type 2 diabetes and related traits, while protecting the integrity and confidentiality of the underlying data | project team only + outside PIs | via coordinating center | to access data |
| Illuminating the Druggable Genome (IDG) | RRID:SCR_016924 | Sponsorship by NIH’s Common Fund has established the program called Illuminating Druggable Genome (IDG) Consortium with the aim of highlighting current knowledge of protein targets through integration of informatics tools, and further study the function of specific understudied targets in three main druggable protein families: G-protein coupled receptors, ion channels and protein kinases. | project team | via coordinating center (PHAROS) | to access data |
| KOMP-IMPC | RRID:SCR_006158 | The IMPC is currently composed of 19 research institutions and 5 national funders from 11 countries. Global infrastructure recognized by the G7; creating 20,000 knockout strains on a single background strain; characterizing each through a standardized phenotyping protocol; integrating the data to existing mouse and human disease resources; providing strains and phenotype data for use by the research community. | project team | via coordinating center | to access data |
| Metabolomics Workbench | RRID:SCR_013794 | The Metabolomics Consortium Data Repository and Coordinating Center (DRCC) at the University of California San Diego has recently processed and curated it's 1,000th metabolomics study. This collection of experimental datasets contains submissions from over 200 different institutions around the world and represents over 70 different species with the majority coming from human (47%) and mouse (31%) sample sources. | project team + outside PIs | via coordinating center | to access data |
| Protein Capture Reagents Program | RRID:SCR_006570 | The goal of the Common Fund’s Protein Capture Reagents program is to develop a community resource of renewable, high-quality protein capture reagents, with a focus on the creation of transcription factor reagents and testing next generation capture technologies. | project team | via coordinating center | to access data |
DEM Clinical Studies & Trials
| Resource Name | RRID | Description | Data Deposition | Data Sharing | Data/Resource Access Points |
|---|---|---|---|---|---|
| Center for Identification and Study of Individuals with Atypical Diabetes Mellitus | The purpose of this Center is to: foster the study of individuals with rare/atypical forms of diabetes mellitus; identify and analyze phenotypic and genotypic defects that may provide insights into more common, heterogeneous forms of Type 2 diabetes mellitus (T2DM) in the general population; and develop a community resource to advance research in this area through the collection and dissemination of data and samples for access by the broad research community. | project team only | via coordinating center | to access specimens & data- TBD | |
| Collaborative Islet Transplant Registry (CITR) | RRID:SCR_001466 | The mission of the Collaborative Islet Transplant Registry (CITR) is to expedite progress and promote safety in islet/beta cell transplantation through the collection, analysis, and communication of comprehensive and current data on all islet/beta cell transplants performed in North America, as well as some European and Australian centers. | project team only | via coordinating center | to access data |
| Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Inteventions and Complications (EDIC) | RRID:SCR_006805 | The Diabetes Control and Complications Trial (DCCT) was a multicenter, randomized clinical trial designed to compare intensive with conventional diabetes therapy with regard to their effects on the development and progression of the early vascular and neurologic complications of type 1 insulin-dependent diabetes mellitus. | project team only | NIDDK central repository | to access specimens & data |
| Diabetes Prevention Program (DPP/DPPOS) | RRID:SCR_001501 | The Diabetes Prevention Program (DPP) is a clinical trial that investigated whether modest weight loss through dietary changes and increased physical activity or treatment with the oral diabetes drug metformin (Glucophage) could prevent or delay the onset of type 2 diabetes in high risk individuals with prediabetes. | project team only | NIDDK central repository | to access specimens & data |
| Diabetes Prevention Trial - Type 1 Diabetes (DPT-1) | RRID:SCR_001467 | The Diabetes Prevention Trial—Type 1 Diabetes (DPT-1) consisted of two randomized clinical trials to determine whether insulin could prevent or delay the onset of overt diabetes in relatives of patients with diabetes. One study investigated the effects of parenteral insulin in relatives with a projected five-year risk of diabetes higher than 50 percent, while the other looked at the effects of oral insulin in relatives with a projected five-year risk of 26 to 50 percent. | project team only | NIDDK central repository | to access specimens & data |
| Glycemia Reductoin Approaches in Diabetes (GRADE) | RRID:SCR_014384 | The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) is a multicenter, parallel-group clinical trial designed to compare the major drug classes currently used to treat T2DM, with the ultimate goal of providing better guidance to practitioners in the choice of medications. Specifically, the GRADE study will compare the effects of four different glucose-lowering medications when combined with metformin, the standard therapy for T2DM, in patients with T2DM. | project team only | NIDDK central repository | to access specimens |
| HEALTHY | RRID:SCR_001530 | The HEALTHY study is a randomized prevention trial that investigated the effectiveness of an integrated intervention in middle schools that aimed to moderate risk for type 2 diabetes in children. The trial was conducted at 7 field centers in 42 middle schools, randomly assigned to intervention or control. | project team only | NIDDK central repository | to access specimens & data |
| Immune Tolerance Network (ITN) | RRID:SCR_001535 | The mission of the Immune Tolerance Network (ITN) is to advance the clinical application of immune tolerance by performing high quality clinical trials of emerging therapeutics integrated with mechanism-based research. | project team only | via ITN coordinating center | to access specimens & data |
| Restoring Insulin Secretion Study (RISE) | RRID:SCR_014383 | The Restoring Insulin Secretion Study (RISE) is determining whether medication or surgical intervention strategies can mitigate progressive ß-cell dysfunction in adults and youth with prediabetes or early type 2 diabetes. | project team only | none | |
| The Environmental Determinants of Diabetes in the Young (TEDDY) | RRID:SCR_000383 | The Environmental Determinants of Diabetes in the Young (TEDDY) study is a multicenter prospective cohort study that was established in response to these gaps in understanding of T1D. The primary objectives of the study include identifying environmental factors—such as infectious agents, dietary factors, and psychosocial factors—that trigger or protect against the development of islet autoimmunity and T1D and examining genetic-environmental interactions to investigate interactive effects that contribute to T1D. | project team only | to access data - TEDDY CC | to access specimens & data |
| Treatment Options for type 2 Diabetes in Adolescents (TODAY) | RRID:SCR_001547 | The TODAY study tested the hypothesis that an aggressive approach to reducing insulin resistance early in the course of T2DM would prolong glycemic control and improve associated risk factors. | project team only | NIDDK central repository | to access specimens & data |
| Trial Net | RRID:SCR_001508 | Type 1 Diabetes TrialNet (TrialNet) is an international network of researchers who are exploring ways to prevent, delay and reverse the progression of type 1 diabetes. | project team only | NIDDK central repository | to access specimens & data |
DDN Basic Studies
| Resource Name | RRID | Description | Data Deposition | Data Sharing | Data/Resource Access Points |
|---|---|---|---|---|---|
| International Inflammatory Bowel Disease Genetics Consortium (IIBDGC) | RRID:SCR_001461 | In recent years the IIBDGC has focused on collecting very large datasets from a diverse set of countries via world-wide collaboration. In addition to enabling the discovery of all these genes, we also try to dig a little deeper into what these associations actually mean | project team + outside PIs | via coordinating center | to access data |
| Intestinal Stem Cell Consortium (ISCC) | RRID:SCR_001555 | The Intestinal Stem Cell Consortium (ISCC) consists of collaborative projects to characterize the minimal, required niche factors that support intestinal stem cells in health and disease, using an integrated, multidisciplinary team science approach. | project team | via coordinating center |
DDN Clinical Studies & Trials
| Resource Name | RRID | Description | Data Deposition | Data Sharing | Data/Resource Access Points |
|---|---|---|---|---|---|
| Acute Liver Failure Study Group | RRID:SCR_001463 | ||||
| Adult Living Donor Liver Transplantation (A2ALL) | RRID:SCR_001494 | The Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) was a consortium of 9 U.S. liver transplant centers performing adult-to-adult living donor liver transplant (AALDLT) with the primary goal of examining outcomes of AALDLT versus deceased donor liver transplant (DDLT). | project team | NIDDK central repository | to access specimens & data |
| African American Study of Kidney Disease and Hypertension Cohort Study & Clinical Trial (AASK) | RRID:SCR_006985 | The African American Study of Kidney Disease and Hypertension Cohort Study (AASK Cohort) is a prospective, observational study that is an extension of the AASK Clinical Trial, which investigated the effects of two levels of blood pressure (BP) control and the use of thre antihypertensive durg regimens on the progression of chronic kidney disease. | project team | NIDDK central repository | to access specimens & data |
| Childhood Liver Disease Research Network | RRID:SCR_001497 | project team | via coordinating center | ||
| Drug-Induced Liver Injury Network (DILIN) | RRID:SCR_001524 | The Drug-Induced Liver Injury Network (DILIN) was established in 2003 as a cooperative agreement among the National Institutes of Health, 5 academic clinical centers, and a data coordinating center. A major emphasis of DILIN has been to establish a protocol for the identification and enrollment of patients with clinically significant DILI into a prospective observational study and to create a registry and specimen repository of biological samples that could be used for mechanistic studies on the etiology and prevention of DILI. | project team | NIDDK central repository | to access specimens & data |
| Familial Barrett's Esophagus (FBEC) | The Familial Barrett’s Esophagus study was established by the Familial Barrett’s Esophagus Consortium (FBEC) to determine whether cancers develop at an earlier age in multiplex Familial Barrett’s Esophagus (FBE) kindreds, defined as 3 or more members affected by Barrett’s esophagus (BE) or esophageal adenocarcinoma (EAC). Ultimately, the study aims to identify putative susceptibility genes for BE and its associated cancers. | project team | NIDDK central repository | to access specimens & data | |
| Gastroparesis Clinical Research Consortium (GpCRC) | RRID:SCR_006673 | The Gastroparesis Clinical Research Consortium (GpCRC) was established by the NIDDK to advance research on the etiology, natural history, and therapy of gastroparesis. | project team | NIDDK central repository | to access specimens |
| Longitudinal Assessment of Bariatric Surgery (LABS) | RRID:SCR_001536 | LABS is a National Institutes of Health (NIH)-funded consortium of six clinical centers and a data coordinating center working in cooperation with NIH scientific staff to plan, develop, and conduct coordinated clinical, epidemiological, and behavioral research in bariatric surgery. | project team | NIDDK central repository | to access specimens & data |
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The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant 2U24DK097771-09.
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