[Recorded Webinar and Slides Are Available Now!] Join dkNET Webinar: Temporal Plasma Metabolome And Gut Microbiome In An Early-Childhood Study Of Type 1 Diabetes

*Watch recorded webinar here: https://youtu.be/86zKYb38Eb4

*Webinar slides: https://www.slideshare.net/dkNET/dknet-webinar-temporal-plasma-metabolome-and-gut-microbiome-in-sn-earlychildhood-study-of-type-1-diabetes-03122021

Join dkNET Webinar on Friday, March 12, 2021, 11 am - 12 pm PST

Abstract

The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled newborns by screening of HLA-DR-DQ haplogenotypes, and then collected plasma and stool samples for metabolomics and metagenomics analyses under a nested case-control design. Our recent research reported multiple metabolites at various time points heralding the onset of distinct initial islet autoantibodies. An unsupervised clustering analysis of temporal lipidome identified a subgroup of TEDDY children developing autoimmunity at an earlier age compared to the others, similar to the age of population-wide early incidence. In order to identify operational taxonomic units that signal the early-age seroconversion to autoimmunity adjusting for the known metabolic and genetic risk factors, we developed a three-part mixed effect model that integrates the temporal microbiota, risk of disease onset up to a fixed time point, metabolites and other time-invariant risk factors. Application to a subgroup of TEDDY children showed that at their 4-9 months of age, the temporal composition and presence of multiple genera and species were associated with the risk of seroconversion by 18 months of age, adjusting for the reported metabolic risk factors and HLA haplogenotype DR3&4. This method also confirmed that these metabolites and HLA DR3&4 were associated with the risk of early seroconversion to islet autoimmunity.

Presenter: Qian Li, Ph.D. Assistant Professor, Health Informatics Institute, University of South Florida

Dial-in In formation  

Date/Time: Friday, March. 12, 2021, 11 am - 12 pm PST

https://uchealth.zoom.us/meeting/register/tZEkduutrTIuGddTDYKoOoj_1wEEm2A7RkD9

Upcoming webinars schedule: https://dknet.org/about/webinar