[Recorded Webinar and Slides are Available Now!] Join dkNET Webinar: Population-Based Approaches to Investigate Endocrine Communication on Feb. 26

*Watch recorded webinar here: https://youtu.be/2w98-s7BIp8

*Webinar slides: https://www.slideshare.net/dkNET/dknet-webinar-populationbased-approaches-to-investigate-endocrine-communication-02262021

Join dkNET Webinar on Friday, Feb. 26, 2021, 11 am - 12 pm PST

Abstract

Mechanisms of inter-organ signaling have been established as hallmarks of nearly every pathophysiologic condition, where many exist as related and complex diseases. While significant work has been focused on understanding how individual cell types contribute and respond to specific perturbations related to common, complex disease, an equally-important but relatively less-explored question involves how relationships between organs are altered in the context of an integrated living organism. Current technical advances, such as proteomic analysis of plasma or conditioned media, have allowed for a more unbiased visualization and discovery of additional inter-tissue signaling molecules. However, one important feature which is lacking from these approaches is the ability to gain insight as to the function, mechanisms of action and target tissue(s) of relevant molecules. To begin to address these constraints, we initially developed a correlation-based bioinformatics framework which uses multi-tissue gene expression and/or proteomic data, as well as publicly available resources to statistically rank and functionally annotate endocrine proteins involved in tissue cross-talk. Using this approach, we identified many known and experimentally validated several novel inter-tissue circuits. This was this first study to directly link an endocrine-focused bioinformatics pipeline from population data directly to experimentally-validated mechanisms of inter-tissue communication. While these validations provide strong support for exploiting natural variation to discover new modes of communication, these serve as simple proof-of-principle studies and, thus, have promising potential for expansion. Some of these will be discussed during the presentation.

Presenter: Marcus Seldin, Ph.D. Assistant Professor, Biological Chemistry, University of California Irvine 

Dial-in In formation

Date/Time: Friday, Feb. 26, 2021, 11 am - 12 pm PST
https://uchealth.zoom.us/meeting/register/tZ0qdOqhrDkiE9Ypgae0RznWf97hoxrEIRLM

Upcoming webinars schedule: https://dknet.org/about/webinar