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dkNET community events and announcements in May, 2020

Dear dkNET Community,

dkNET provides updates on activities of interest to the NIDDK-supported community. You could keep up to date on these activities through our Twitter feed @dkNET_info, through our Community Calendar, or through dkNET e-mail list. If you have an event or funding opportunities you'd like to advertise, please contact us info_at_dknet.org.


dkNET News

New publication

Congratulations! Our collaborator - Signaling Pathways Project (SPP) team has released a preprint "A transcriptional regulatory atlas of coronavirus infection of human cells" on bioRXiv!


Upcoming dkNET webinars

Friday, May 8, 2020, 11 am - 12 pm PDT    A New approach to the Study of Energy Balance and Obesity using CalR

Friday, May 15, 2020, 11 am - 12 pm PDT  dkNET Hypothesis Center- Signaling Pathways Project Live Demo


Events in May, 2020

May 08, 2020

dkNET Webinar : A New approach to the Study of Energy Balance and Obesity using CalR

Abstract: We report a web-based tool for analysis of experiments using indirect calorimetry to measure physiological energy balance. CalR simplifies the process to import raw data files, generate plots, and determine the most appropriate statistical tests for interpretation. Analysis using the generalized linear model (which includes ANOVA and ANCOVA) allows for flexibility in interpreting diverse experimental designs, including those of obesity and thermogenesis. Users also may produce standardized output files for an experiment that can be shared and subsequently re-evaluated using CalR. This framework will provide the transparency necessary to enhance consistency, rigor, and reproducibility. The CalR analysis software will greatly increase the speed and efficiency with which metabolic experiments can be organized, analyzed per accepted norms, and reproduced and has become a standard tool for the field. CalR is accessible at https://CalRapp.org/ 


May 15, 2020

dkNET Webinar Series: dkNET Hypothesis Center- Signaling Pathways Project Live Demo

The dkNET Hypothesis Center - Signaling Pathways Project (SPP) is a free, open source tool for bench scientists to generate research hypotheses using SPP consensomes, which are lists of genes ranked by their transcriptional responsiveness to signaling pathway nodes. SPP is a hub for big data and hypothesis generation that allows researchers to extract information across different transcriptomic and ChIP-Seq datasets. It is a powerful meta-analysis platform that surveys across millions of biocurated 'omics data points to make high-confidence connections between genomic targets, their upstream regulatory pathways, and disease states.

Funding opportunities information and deadlines in May, 2020


May 01, 2020

IIDP Funding Opportunity Application Due: Islet Aware Initiative

The IIDP Islet Award Initiative is intended to advance research in human islet biology by facilitating the ability of researchers to access human islets for high impact and novel research studies. The number of IIDP Islet Awards funded under this initiative will be determined in any single year based on available resources but will average 3-4 awards per submission date.

More information: https://iidp.coh.org/Investigators/Islet-Award-Initiative

May 01, 2020

International Society of Nephrology Funding Opportunity Application Due: Fellowship Program

Through the ISN Fellowship Programs, Fellows from Low and Middle Income countries get individual and hands-on training in their selected host institutions. They return home with new skills and knowledge in basic and clinical nephrology, dialysis, transplantation, epidemiology. They improve treatment, teach and train others and become future leaders in the developing world. Over the years, this program has also allowed nephrologists from all over the world to train in host centers in their own regions rather than exclusively in North America, Europe or Australasia.

More information: https://www.theisn.org/fellowship

May 11, 2020

NIDDK Funding Opportunity Letter of Intent Due Date: The Physiology of the Weight Reduced State Clinical Trial Consortium (UG3/UH3 Clinical Trial Required)

Following intentional weight loss, physiological processes including altered appetite and decreased energy expenditure create a tendency toward regain of lost weight. This Funding Opportunity Announcement (FOA) invites UG3/UH3 cooperative agreement applications from multi-disciplinary teams that propose to conduct collaborative mechanistic clinical trials focused on elucidation of the physiological mechanisms underlying individual variability in maintenance of reduced weight over time. This FOA will not support studies with a goal to evaluate the efficacy of interventions for weight loss or maintenance of reduced weight. Participants must be studied before and after a successful behavioral/lifestyle weight loss intervention to determine the extent, durability, and mechanisms for physiologic adaptations to weight loss, including metabolic and biobehavioral mechanisms. It is expected that tissue biospecimens will be collected that can be used to identify potential metabolic pathways that are altered after weight loss and may render it more difficult to maintain the reduced weight.

More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-017.html


May 15, 2020

NIH Funding Opportunity Application Due Date: Notice of Special Interest (NOSI): Administrative Supplements to Support Enhancement of Software Tools for Open Science

NIH announced the availability of administrative supplements to active grants that focus on biomedical software development or have a significant software development component to enhance software tools for OpenScience. The goal is to support collaboration between biomedical scientists and software engineers to improve research software. Application due date: May 15, 2020.

More information:  https://dknet.org/about/dknetnews/2062

May 15, 2020

NIH Funding Opportunity: Request for Information Challenges and Opportunities in Understanding Cellular Senescence and Senolytics

The NIH is considering the possibility of developing a Common Fund program to address the role of senescent cells in health and disease. In spite of the burgeoning efforts already in the field attempting to test therapies based on attacking senescent cells, it has become clear that many aspects of cell senescence research are currently in need of answers before the full potential of such therapies can be safely developed in humans. As part of the initial planning process, we are requesting input from the scientific community on the challenges in this field that can best be addressed through a concerted and coordinated effort.

More information:  https://grants.nih.gov/grants/guide/notice-files/NOT-RM-20-014.html


May 18, 2020 (New response date: July 31, 2020)

NIDDK Request for Information Response Deadline: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Strategic Plan

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is embarking on an Institute-wide strategic planning process. The goal of the process is to develop a broad vision for accelerating research into the causes, prevention, and treatment of diseases and conditions within the Institute’s mission. This overarching trans-NIDDK Strategic Plan will complement NIDDK’s disease-specific planning efforts. The strategic plan will have a 5-year time horizon but will also include planning for longer term efforts that could be initiated within this time frame. A critical component of this strategic planning process is to seek input from the research and patient communities and others who have an interest in research within the mission of NIDDK. As part of that approach, the purpose of this Request for Information (RFI) is to invite input on opportunities and strategies to advance NIDDK’s mission.

More information: https://grants.nih.gov/grants/guide/notice-files/NOT-DK-20-015.html


May 18, 2020

NIDDK and NCI Funding Opportunity Letter of Intent Due Date: Development of Wearable Smart Devices for Continuous Monitoring of Circulating Nutrients, Metabolites and Hormones (R21/R33 Clinical Trial Required)

Recent advances in precision nutrition and circadian metabolism have come from studies utilizing continuous glucose monitors. However, diet leads to metabolic excursion of thousands of nutrients and metabolites, some linked to gut microbiota metabolism. Precision nutrition studies would benefit significantly from tools that can be used to monitor the metabolic excursions of other nutrients and metabolites in response to diet or other factors. Such data could help identify quantifiable links between the consumption of specific nutrients or food constituents and patho-physiological processes and the factors that impact health and disease susceptibility along with the factors leading to inter-individual variability in those links.

More information:  https://grants.nih.gov/grants/guide/pa-files/PAR-20-134.html

May 18, 2020

NIDDK and NCI Funding Opportunity Letter of Intent Due Date: Gastrointestinal (GI and Microbiome Explorers: Development of Swallowable Smart Pills or Devices for Precision Nutrition, Microbiome and Digestive Disease Applications (R21/R33 Clinical Trial Required)

The purpose of this Funding Opportunity Announcement is to support the development of tools/devices for sampling or monitoring of diet- gastro-intestinal (GI)(contents and mucosa) and microbial interactions (GI- Microbiome Explorer). It is anticipated that successful completion of the projects completed under this FOA will yield implementable devices/tools for gastroenterological research or other clinical applications, along with monitoring and sampling of GI contents and/or mucosa to examine diet-host-microbiome interactions for clinical research or diagnostic applications.

More information: https://grants.nih.gov/grants/guide/pa-files/PAR-20-133.html


May 18, 2020

NIDDK Funding Opportunity Letter of Intent Due Date: Urological Epidemiology (UroEpi) Institutional Research Career Development Program [K12- Independent Clinical Trial Not Allowed]

This Funding Opportunity Announcement (FOA) invites institutional career development program (K12) applications in the area of epidemiology of benign urological conditions. This institutional program will provide scholars with research and/or clinical doctoral degrees (including MD, PhD, MD/PhD, DrPH) with the skills and resources necessary to initiate an independent research career in the epidemiology of benign urological conditions within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). This Funding Opportunity Announcement (FOA) allows appointment of Scholars proposing to gain research experience in a clinical trial led by another investigator, as part of their research and career development.

More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-20-001.html


May 22, 2020

NIDDK Funding Opportunity Application Due Date: Patient-oriented Research to Mitigate Health Disparities and Lessen the Burden of Chronic Diseases Within the Mission of NIDDK (R01 Clinical Trial Optional)

This Funding Opportunity Announcement invites applications to conduct patient-oriented clinical research studies designed to develop strategies to mitigate health disparities in people with one or more chronic diseases or conditions within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Populations of interest include those disproportionately burdened with multiple chronic conditions and/or disparities in social, behavioral and/or biological risk factors. Only studies that involve interaction with human participants will be considered appropriate for this FOA.

More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-20-015.html


May 25, 2020

NIH Funding Opportunity Letter of Intent Due: Native American Research Centers for Health (NARCH) (S06 Clinical Trials Optional)

The National Institute of General Medical Sciences, in conjunction with the Institutes/Centers of the National Institutes of Health (NIH) listed above in the "Components of Participating Organizations" section and the Indian Health Service (IHS), invites applications from federally recognized Tribes and Tribal organizations for the Native American Research Centers for Health (NARCH) initiative. The objective of the NARCH initiative is to support biomedical research and career enhancement opportunities to meet health needs prioritized by American Indian/Alaska Native (AI/AN) communities.  The NARCH initiative also supports research capacity building and the development of research infrastructure to enhance the biomedical research capabilities of AI/AN communities.

More information: https://grants.nih.gov/grants/guide/pa-files/PAR-20-125.html


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