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Norway

Hypothesis Center

About

dkNET is partnering with the Signaling Pathways Project (SPP) knowledge base, which has developed a powerful new meta-analysis platform, consensomes, that surveys across millions of DK mission-relevant biocurated 'omics data points to make high-confidence connections between genomic targets, their upstream regulatory pathways, and the disease states in which their expression is altered. SPP simplifies powerful data mining and hypothesis generation strategies for the bench researcher, putting a 200 million data point-strong universe of 'omics data points at their fingertips.



Read more:

Becnel, LB et al. Discovering relationships between nuclear receptor signaling pathways, genes, and tissues in Transcriptomine. Sci Signal. 2017 Apr 25;10(476). pii: eaah6275. doi: 10.1126/scisignal.aah6275.

Darlington, TF et al. Improving the discoverability, accessibility, and citability of omics datasets: a case report. J Am Med Inform Assoc. 2017 Mar 1;24(2):388-393. doi: 10.1093/jamia/ocw096

Ochsner S et al. The Signaling Pathways Project: an integrated 'omics knowledgebase for mammalian cellular signaling pathways. bioRxiv Preprint. 2018. doi: https://doi.org/10.1101/401729

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