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URL: https://web.expasy.org/cellosaurus/CVCL_E8AV
Proper Citation: RRID:CVCL_E8AV
Description: Cell line X4-MaRBLE is a Cancer cell line with a species of origin Homo sapiens (Human)
Sex: Male
Disease: Childhood T acute lymphoblastic leukemia
Defining Citation: PMID:17182760
Comments: Virology: Susceptible to infection by CXCR4-tropic HIV-1 strains (example HXB2) (PubMed=17182760)., Virology: Infected with Moloney murine leukemia virus (MoMuLV) from MiCl1 (S+L-) (Cellosaurus=CVCL_3405) cells (from parent cell line HPB-Ma)., Characteristics: Transfected with two constructs. 1) 53LTRN-lucneoR#1 which contains the HIV-1 strain HXB2 LTR driving the expression of a Luc-DsRed fusion protein. This allows HIV-1 replication to be quantitatively evaluated by using luciferase activity when the LTR is activated by Tat, and the DsRed gene allows HIV-1 infected cells to be identified by red fluorescence. 2) pRenillaPac where Renilla luciferase is under the control of a CMV promoter and is used to monitor cell numbers and viability (PubMed=17182760)., Characteristics: Reporter cell line to measure HIV-1 infectivity and thus evaluate susceptibility to anti-HIV-1 drugs (PubMed=17182760)., Population: Japanese.
Category: Cancer cell line
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Source: Cellosaurus
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