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URL: https://web.expasy.org/cellosaurus/CVCL_3962
Proper Citation: RRID:CVCL_3962
Description: Cell line LN-464 is a Cancer cell line with a species of origin Homo sapiens (Human)
Sex: Sex unspecified
Disease: Melanoma
Defining Citation: PMID:7693337, PMID:8509230, PMID:10416987, PMID:22570425, PMID:25984343, PMID:31068700
Comments: Population: Caucasian., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)., Problematic cell line: Contaminated. The STR profile of ACN and LN-464 are identical. SNP analysis (DepMap) also shows identity of both cell lines. Personal communication of Hegi, Monika E. confirms the mismatch between the STR profile of this cell line and of the patient from which LN-464 was established. We believe this is a melanoma cell line based on the RNASeq expression profile of LN-464 (DepMap) which clusters with that of melanoma patient samples. The presence of the BRAF V600E while present at low frequency in gliomas is also a hallmark of melanomas. Originally thought to originate from the brain right parieto-occipital lobe of a 67 year old male patient with a glioblastoma..
Category: Cancer cell line
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Source: Cellosaurus
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