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Certain sets of genes are derived from gene duplication and share substantial sequence similarity in C. elegans , presenting a significant challenge in determining the specific roles of each gene and their collective impact on cellular processes. Here, we show that a collection of genes can be disrupted in a single animal via multiple rounds of CRISPR/Cas9 mediated genome editing. We found that up to three genes can be simultaneously disrupted in a single editing event with high efficiency. Our approach offers an opportunity to explore the genetic interaction and molecular underpinning of gene clusters with redundant function.
Pubmed ID: 38033425
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Center that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentionsCaenorhabditis elegans with name npr-1(ad609) X. from WB.
View all literature mentionsCaenorhabditis elegans with name srh-185(yum2493) srh-186(yum2494) srh-187(yum2495) srh-190(yum2496) srh-192(yum2497) srh-193(yum2498) srh-194(yum2499) srh-195(yum2500) srh-199(yum2501) srh-200(yum2502) srh-201(yum2503) srh-203(yum2504) srh-204(yum2505) srh-206(yum2506) srh-207(yum2507) srh-208(yum2508) srh-209(yum2509) V. from WB.
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