Join dkNET Webinar on Friday, December 6, 2024, 11 am - 12 pm PT

Presenter: Changhan He, PhD. Visiting Assistant Professor, Department of Mathematics, University of California, Irvine

Abstract

Cells make decisions through their communication with other cells and receiving signals from their environment. Different computational tools have been developed to infer cell-cell communication through ligands and receptors using single-cell transcriptomics. However, existing methods only address signals sent by the cells measured within the dataset, leaving out signals received from external sources. This presentation introduces exFINDER, a computational approach designed to identify external signals received by cells in single-cell transcriptomics datasets and explo res the analysis of related ligand-target signaling networks.

The top 3 key questions that exFINDER can answer:

1. What external signals influence cellular behavior within a single-cell transcriptomics data set?

2. What are the most critical external signals and target genes of the inferred ligand-target signaling networks?

3. Which biological processes are associated with the ligand-target networks identified by exFINDER?

Resource link: https://github.com/ChanghanGitHub/exFINDER More information: https://dknet.org/about/blog/2793