dkNET Webinar: Expanding Human Islet Research via the Integrated Islet Distribution Program (IIDP) Research Data Repository

Join dkNET Webinar on Friday, November 22, 2024, 11 am - 12 pm PT

Presenters:
Joyce Niland, PhD, Professor & Endowed Chair, Department of Diabetes & Cancer Discovery Science, IIDP Principal Investigator, City of Hope, Duarte CA

James Cravens, MPH, IIDP Program Manager, City of Hope, Duarte, CA

Abstract

The Integrated Islet Distribution Program (IIDP - formerly the Islet Cell Resource Center Consortium from 2002-2009), is sponsored by the National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) to provide crucial availability of high-quality human islets, associated tissues, and rich complementary data for diabetes research. As one of the largest islet distribution programs worldwide, the IIDP has supplied more than 291 million islet equivalents to 594 unique research studies, supporting over 950 peer reviewed publications. The IIDP has improved protocol standardization and methodology, enhanced donor data through reporting genetic ancestry and T1D/T2D risk scores, expanded islet quality and phenotypic information, and provides ancillary tissues matched to the islets. In 2019, IIDP released the Research Data Repository (RDR) to provide direct access to integrated data across all islet isolations for any approved researcher, including donor information, United Network for Organ Sharing (UNOS) data, islet broadcast details, genetic risk scores and phenotyping results. Via the RDR, investigators can establish search criteria, select desired data points, save searches created, and download a resulting file for data exploration into the relationships between multiple donor factors and islet biology. Through its partnership with dkNET and the National Center for Biotechnology Information (NCBI), the IIDP was an early adopter of Research Resource Identifiers (RRIDs) for all IIDP records, to promote data transparency, rigor and analytic reproducibility, a facet that will become even more critical as new advances in artificial intelligence (AI) and machine learning (ML) make expanded, more complex analyses feasible.

The top 4 questions that the IIDP RDR can answer:
1. What characteristics and exposures of the pancreas donor influence a successful islet yield?
2. How does genetic risk for Type 2 diabetes vary with ancestry?
3. What factors impact the composition of the major islet cell types (alpha, beta gamma)?
4. You tell us! The IIDP is offering a new funding opportunity through February 2025 for data projects using our Research Data Repository (RDR): the Data Resource Trainee Scholar Award (DRTSA). Please visit https://iidp.coh.org/Resources-Offered/Research-Data-Repository to view the type of available IIDP data and begin to craft your own hypothesis. Additional information about the upcoming DRTSA will be available at https://iidp.coh.org/DRTSA_2025 in the near future, including eligibility criteria.

Dial-in Information: https://uchealth.zoom.us/meeting/register/tZcqf-uhqDgoG9EETnvV2RFtRhCIO5fbwZJZ

Date/Time: Friday, November 22, 2024, 11 am - 12 pm PT

Upcoming webinars schedule: https://dknet.org/about/webinar