[Recorded Webinar and Slides are Available Now!] dkNET Webinar: A Single Cell Atlas of Human and Mouse White Adipose Tissue

*Watch recorded webinar here: https://youtu.be/6m-ZQ2NhU6A

*Webinar slides:
https://www.slideshare.net/dkNET/dknet-webinar-a-single-cell-atlas-11172023-of-human-and-mouse-white-adipose-tissue

Join dkNET Webinar on Friday, November 17, 2023, 11 am - 12 pm PT

Presenter: Margo Emont, PhD. Instructor, Beth Israel Deaconess Medical Center/Harvard Medical School

Abstract

White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defense. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.

The top 3 key questions that this resource can answer:

1. How specific is my gene of interest to a particular cell type in adipose tissue?

2. Is the gene/pathway that I am studying in mouse adipose tissue also present in human adipose tissue (and is it regulated similarly in low vs high body weight)?

3. What are the changes in gene expression in a specific cell type at low vs high body weight?

Resource link: 
https://singlecell.broadinstitute.org/single_cell/study/SCP1376/a-single-cell-atlas-of-human-and-mouse-white-adipose-tissue#study-summary

Dial-in Information: https://uchealth.zoom.us/meeting/register/tZIvduGvpjstGdQhMFKNAbQVPgSCa-q7SY2n

Date/Time: Friday, November 17, 2023, 11 am - 12 pm PT

Upcoming webinars schedule: https://dknet.org/about/webinar