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dkNET community events and announcements in July, 2023

Dear dkNET Community,

dkNET provides updates on activities of interest to the NIDDK-supported community. You could keep up to date on these activities through our Twitter feed @dkNET_info, through our Community Calendar, or through dkNET e-mail list. If you have an event or funding opportunities you'd like to advertise, please contact us info_at_dknet.org.


dkNET News
  • dkNET Biomed Resource Reports is Released dkNET is excited to announce an exciting new service - Biomed Resource Watch (BRW, https://scicrunch.org/ResourceWatch), a knowledge base for aggregating and disseminating known problems and performance information about research resources such as antibodies, cell lines, and tools. With this tool, researchers can report their claims about a specific resource. If you missed the webinar, here are the recording and slides. Check out our blog article about BRW!


  • Congratulations to the 2023 dkNET Summer of Data Student Program Awardees! The summer program kicked off this month! This year we have 15 students from high school to graduate programs in the U.S.A. Our program teaches young researchers about dkNET and online resources, FAIR data, data management, and reproducibility skills to apply in their research projects! Learn more:https://dknet.org/about/summer_program_student_2023



  • Recordings and Slides are Now Available: (1) dkNET Webinar “Defining the Spatiotemporal and Molecular Trajectory of Beige Adipogenesis” presented by Dr. Nabil Rabhi on May 12, 2023: Recording (2) dkNET Webinar “Leveraging Computational Strategies to Identify Type 1 Diabetes Risk and Clinical Trial Responder Status” presented by Dr. Wenting Wu on May 19, 2023: Slides; Recording.


  • New Resources added to dkNET
    • Diabetes Data and Hypothesis Hub (RRID:SCR_023629) is a platform that facilitates data-driven hypothesis generation for diabetes and related metabolic disorder research communities. Curated transcriptomics datasets from various Type 2 Diabetes studies are made available for download, visualization, and enrichment analysis.

    • TargetRanger (RRID:SCR_023621) is a web server application that identifies targets from user-inputted RNA-seq samples collected from cells we wish to target. By comparing inputted samples with processed RNA-seq and proteomics data from several atlases, TargetRanger identifies genes that are highly expressed in target cells while lowly expressed across normal human cell types, tissues, and cell lines.

    • GeneRanger (RRID:SCR_023622) is a web server application that provides access to processed data about expression of human genes and proteins across human cell types, tissues, and cell lines from several atlases. It is used to explore single gene expression across tissues and cell types.

    • Kinase Enrichment Analysis 3 (RRID:SCR_023623) is a web server application that infers overrepresentation of upstream kinases whose putative substrates are in user inputted list of proteins. It is used to analyze data from phosphoproteomics and proteomics studies to predict upstream kinases responsible for observed differential phosphorylations.

    • X2K Web (RRID:SCR_023624) is a web service to predict involvement of upstream cell signaling pathways, given signature of differentially expressed genes. It is used to link expression signatures to upstream cell signaling networks.


    • TIGER Data Portal (RRID:SCR_023626) is a resource that enables integrative exploration of genetic and epigenetic basis of development of Type 2 Diabetes, together with other associated functional, molecular and clinical data, centered in biology and the role of pancreatic beta cells. The gene expression regulatory variation landscape of human pancreatic islets.

    • Liver cell atlas (RRID:SCR_023627) is a portal to search liver single-cell RNA-sequencing datasets. It contains datasets for expression of genes or proteins (when CITE-seq was performed). 

    • IDF Diabetes Atlas (RRID:SCR_023628) is an atlas that aims to provide regular information on the state of diabetes. It contains reports, produced annually, epidemiological and diabetes-related impact data including the impact of type 2 diabetes in indigenous peoples, type 1 diabetes across all age groups, COVID-19 among people with diabetes, and diabetes foot-related complications.

Events in July 2023

Jul. 06, 2023

Keystone Symposia Abstract and Scholarship Application due: Circulating Metabolic Intermediates as Fuels and Signals

Metabolic diseases such as stroke, heart disease, diabetes, cancer, obesity, and NASH remain major causes of death and disability. One reason is incomplete understanding of energy metabolism and its regulation. New data indicate that metabolites normally viewed as wastes or benign intermediates are actually important fuels and signals. For example, lactate has emerged as an important energy substrate and succinate as a driver of muscle remodeling, reflecting the many underexplored energetic and regulatory roles of circulating metabolic intermediates. The importance of such intermediates, as opposed to classical “fuels” like glucose, amino acids and fat, opens a new perspective on how energy metabolism is controlled. Thus, this field is primed for further break-throughs – both in understanding of new biology and in offering new targets for intervention. Conference dates: October 8-11, 2023. Scholarship application deadline: July 6, 2023. Abstract deadline: July 6, 2023.

Location:  Snowbird Resort, UT

More information: https://www.keystonesymposia.org/conferences/conference-listing/meeting?eventid=6867


Jul. 12, 2023

HIRN Webinar: RNA Processing in Metabolic Tissues

Presentations by:    - Lori Sussel, PhD, University of Colorado- Rohit Kulkarni, MD, PhD, Joslin Diabetes CenterTopics to be Discussed:- Introduction: RNA processing is an important layer of regulation in the islet - RNA Splicing: Endocrine cell-specific RNA-splicing, alternate splicing in diabetic islets, splicing defects contribute to beta cell dysfunction, - RNA Modifications: Types of mRNA modifications in metabolic tissues, significance of m6A mRNA methylation in type 1 and type 2 diabetes, role of m6A and pseudouridine in mRNA and carRNA regulation.

More information: https://cityofhope.zoom.us/meeting/register/tJwpce-rqTMiGNIx8bzl7ewiAfuX5H8dder8#/registration


Jul. 13, 2023

the(sugar)science webinar: How leveraging epigenetic heterogeneity resulted in the identification of two major ? cell subsets? - Dr. Erez Dror

For Dr. Dror doctoral studies at the laboratory of Marc Donath, university of Basel, Switzerland, he investigated the role of postprandial inflammatory response in glucose homeostasis (Nat Immunol, 2017). Later, interested in the molecular underpinning that define “cell-types” he started his Postdoc research in Andrew Pospisilik’s group at the Max-Planck institute for immunobiology and Epigenetics, Germany. There, he developed a method in order to study a novel epigenetic heterogeneity in ?-cells (SCAN-seq). This resulted with the identification of two novel ?-cell sub-sets with specific epigenetic rewiring in which he will talk about in my presentation (Cell Metab 2023).His next goal is to establish my own research group that will utilize SCAN-seq in order to study intra cell-cell interactions within the pancreatic islets and within other key metabolic tissues such as adipose, liver, brain.

More information: https://us02web.zoom.us/meeting/register/tZYsc-CorTwqEtey6M1tuPh_tY6-3bVHx30c#/registration



Jul. 24-25, 2023

NIDDK Webinar: Optimizing Clinical Trials In Chronic Disease

This workshop will identify areas of improvement in planning better clinical trials and will consider the key factors that are critical to a successful trial, including patient and stakeholder engagement, pre-trial analysis of the study population and landscape, with a focus on better planning and achieving optimal recruitment. Registration deadline: July 23, 2023.

Location:  Virtual

More information: https://www.niddk.nih.gov/news/meetings-workshops/2023/optimizing-clinical-trials-in-chronic-disease


Jul. 26, 2023

NIDDK Workshop: Interventions for Pancreatitis: New Approaches, Knowledge Gaps, and Research Opportunities

Recent NIDDK Workshops have focused on the requirements for designing and conducting clinical trials in pancreatitis.The breadth and variety of currently planned or underway interventions include behavioral interventions, nutritional studies, studies with pharmacologic and biologic agents, and mechanical studies with endoscopy and surgery. This one-day workshop aims to inform investigators of new developments in the field and identify the knowledge gaps and research opportunities that might inform possible future funding initiatives for NIDDK.

Location: Pittsburgh, PA, USA

More information: https://www.niddk.nih.gov/news/meetings-workshops/2023/interventions-for-pancreatitis


Funding Opportunities Information and Deadlines in July 2023


Jul. 08, 2023

NIH Funding Opportunity Application Due: Native American Research Centers for Health (NARCH) (S06 Clinical Trial Optional)

The purpose of the Native American Research Centers for Health (NARCH) program is to fund federally-recognized American Indian/Alaska Native (AI/AN) tribes, tribal colleges or universities, tribal health programs, or tribal organizations (collectively, eligible AI/AN tribal entities) to support health-related research, research career enhancement, and research infrastructure enhancement activities. Application Due Date: July 8, 2023.

More information: https://grants.nih.gov/grants/guide/pa-files/par-23-166.html



Jul. 11, 2023

NIDDK Funding Opportunity First Available Due: Notice of Special Interest: Administrative Supplements to Support Collaborations to Improve Data Interoperability/Re-use for Existing Type 2 Diabetes Relevant Data Sets

The Division of Diabetes, Endocrinology and Metabolic Diseases (DDEMD) in NIDDK currently supports numerous data rich projects designed to collect an array of human data types with the goal of understanding the heterogeneity and pathogenesis of Type 2 Diabetes (T2D), and to develop appropriate prevention and treatment strategies.  

The goal of this Notice of Special Interest (NOSI) is to provide support through administrative supplements collaborations to improve interoperability/re-use for NIDDK supported T2D data sets and related resources such as repositories and knowledgebases.  This initiative is aligned with the NIDDK Strategic Plan for Research, which describes research opportunities aimed at developing innovative technologies and resources to expand data science to advance scientific progress and enhance health, and to utilize data science to improve clinical studies.  

This NOSI is soliciting administrative supplements from existing awardees funded by NIDDK's DDEMD. Projects are eligible to apply if they have at least one year of support remaining in the project period as of July 1, 2023.  First Available Due Date: July 11, 2023.

More information: https://dknet.org/about/dknetnews/2635



Jul. 17, 2023

IIDP Funding Opportunity Application Due: The Technology Resource Award (TRA)

The Technology Resource Award (TRA) is intended to advance research of human islets and other non-islet pancreatic biomaterials (e.g. acinar, ductal tissues, lymph nodes, duodenum) by providing support for high-impact studies that will enhance services provided by IIDP to the human islet research community. Up to $150,000 will be available per award. Letter of Intent: June 15, 2023.

More information: https://iidp.coh.org/TRA_2023



Jul. 17, 2023

IIDP Funding Opportunity Application Due: The Data Resource Trainee Scholar Award (DRTSA)

The Data Resource Trainee Scholar Award (DRTSA) is intended to advance research in human pancreas biology by providing trainees with support and access to detailed donor and islet data contained within the IIDP’s Research Data Repository (RDR) that will enable important secondary analyses to explore the relationships among donor characteristics, islet phenotyping, and genetic risk. Up to $10,000 will be available per award. Letter of Intent deadline: June 15, 2023.

More information: https://iidp.coh.org/DRTSA_2023



Jul. 17, 2023

NIDDK Pre-Application Webinar for Evaluating Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) and Potential Risk and Protective Factors (RFA-DK-23-009 and RFA-DK-23-010)

At this webinar, staff members will provide a brief overview of funding opportunities RFA-DK-23-009 and RFA-DK-23-010, explain the goals and objectives, and answer questions. Prior to the meeting, registered participants will receive the link to join the webinar via email.

More information: https://www.niddk.nih.gov/news/meetings-workshops/2023/evaluating-neurocognitive-complications-of-pediatric-type-1-diabetes

Jul. 20, 2023

NIDDK Funding Opportunity Application Due: Pilot and Feasibility Trials on the Integration of Social and Medical Care for Type 1 Diabetes Mellitus (R01 Clinical Trial Required)

The purpose of this NIDDK Funding Opportunity Announcement (FOA) is to support pilot and feasibility trials to test pragmatic interventions that include screening for adverse social determinants of health (SDoH) and referring or providing resource service linkages for social services within the healthcare setting for individuals living with type 1 diabetes. The pilot trials will determine 1) feasibility of screening for social risks and implementing referral service linkages (e.g., connecting persons in need to appropriate transportation, housing, food, etc. resources) within the context of a healthcare encounter, and 2) preliminary signals of the interventions impact on both the social risk(s) and type 1 diabetes (T1D) specific outcomes such as glycemic control. The overarching goal of this FOA is to stimulate collaborations between healthcare systems, community-based organizations, and social service entities for testing and advancing effective interventions which integrate social care and medical care to reduce health disparities in T1D. Letter of Intent Due Date: June 20, 2023; Application Due Date: July 20, 2023.

More information: https://grants.nih.gov/grants/guide/rfa-files/rfa-dk-22-028.html



Jul. 24, 2023

Submission Deadline: 2023 DataWorks! Challenge

The 2023 DataWorks! Prize will focus on best practice “recipes” that advance biological and biomedical research activities, with a focus on practices enabling robust data management during the research process. Participants will submit their data sharing/reuse best practice recipes in a form that can be used by an audience of their peers, such as a teaching resource or tool for active data management. Submission deadline: July 24, 2023.

More information: https://dknet.org/about/dknetnews/2630



Jul. 30, 2023

NIDDK Funding Opportunity Letter of Intent Due: Human Liver Tissue and Hepatocytes Resource-Related Research Project (R24 Clinical Trial Not Allowed)

The purpose of this Notice of Funding Opportunity (NOFO) is to support a Human Liver Tissue and Hepatocytes Research Resource (HLTHRR) program to enable the continued availability of human liver tissue and hepatocytes to biomedical researchers. The research resource is expected to facilitate the procurement and preservation of human liver tissue and hepatocytes as well as the distribution of these materials to qualified biomedical researchers. Applications focused on animal liver and/or hepatocytes studies will not be considered responsive to this NOFO. Letter of Intent Due Date: July 30, 2023. Application Due Date: August 30, 2023.

More information: https://grants.nih.gov/grants/guide/rfa-files/rfa-dk-23-012.html

Jul. 30, 2023

NIDDK Funding Opportunity Letter of Intent Due: Undergraduate Summer Research Education in Kidney, Urologic, and Hematologic Diseases (R25 Clinical Trial Not Allowed)

The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH.  The overarching goal of this R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation’s biomedical, behavioral and clinical research needs.To accomplish the stated over-arching goal, this NOFO will support educational activities with a primary focus on: Research Experiences. This NOFO solicits applications to establish summer research programs for qualified undergraduates and recent post-baccalaureates to participate in summer research experiences relevant to the mission of the Division of Kidney, Urologic and Hematologic Diseases/NIDDK (NIDDK/KUH). Application Due Date: August 30, 2023.

More information: https://grants.nih.gov/grants/guide/rfa-files/rfa-dk-23-013.html



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