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dkNET community events and announcements in January, 2023

Dear dkNET Community,

dkNET provides updates on activities of interest to the NIDDK-supported community. You could keep up to date on these activities through our Twitter feed @dkNET_info, through our Community Calendar, or through dkNET e-mail list. If you have an event or funding opportunities you'd like to advertise, please contact us info_at_dknet.org.


dkNET News

  • Happy Holidays from the dkNET team! Thank you for your continued support in 2022. We wish you all the success in 2023! 

               
  • The dkNET/SPP/NDEx Project Has Been Named as a Finalist in the  DataWorks! Challenge Congratulations! The dkNET project and Signaling Pathways Project (SPP) along with NDEx have been named as a finalist in the NIH/FASEB DataWorks! Challenge, which recognizes data reuse in scientific discovery. Learn about our project: https://dknet.org/about/blog/2532

 

  • Upcoming dkNET Office Hours for Data Management and Sharing Plan Assistance Are you ready for the new NIH Data Management and Sharing Plan (effective Jan. 21, 2023)? Have questions or need help? Join dkNET Office Hours on Friday, January 13, 2023, 11 am - 12 pm PT! Register now! https://dknet.org/about/blog/2535. You can also check dkNET resources to help you comply with the new mandates here: https://dknet.org/rin/research-data-management

 

 

 

  • The 2022 D-Challenge Winner Announced! Congratulations to the D-Challenge winners! Thanks to all who helped make this a success, and thank you to all participants who used the rich ecosystem of online tools and data findable through dkNET to develop the Type 1 Diabetes hypotheses! Link: https://dknet.org/about/blog/2534


  • New Publication Congratulations to dkNET PIs Drs. Maryann Martone and Jeffrey Grethe, Resource Identification Initiative lead Dr. Anita Bandrowski, and the Antibody Registry team on publishing a new paper "The Antibody Registry: ten years of registering antibodies" in Nucleic Acids Research https://dknet.org/about/blog/2519

 

  • dkNET team at Cell Bio 2022 Thank you to everyone who stopped by our booth and poster presentations. It was our pleasure to meet so many great scientists! We hope you all enjoyed the meeting! Here is a list of feature highlights from the dkNET portal in this meeting: https://dknet.org/about/blog/2529. We are recruiting beta testers for the Biomed Resource Watch. Contact info@dknet.org if you are interested!

 

  • dkNET team at the 2022 CAIRIBU Annual Meeting in Bethesda, MD dkNET's Co-P.I. Dr. Jeffrey Grethe introduced dkNET resources at the 2022 CAIRIBU (Collaborating for the Advancement of Interdisciplinary Research in Benign Urology) Annual Meeting on Nov. 30 and Dec. 1, 2022. Dr. Maryann Martone also gave a presentation at the CAIRIBU ARCTICS community forum in November 2022. Thanks for the invitation from the CAIRIBU organizers and thanks to all who joined our presentations! dkNET created a special resource collection to help the community to discover urology research-related resources through dkNET easily. Learn more: https://dknet.org/about/blog/2539


  • New Resources added to dkNET
           Resources highlights- Resources developed by the dkNET New Investigator Pilot Program in Bioinformatics Awardees
    • APA-Scan (RRID:SCR_022974) is a software Python tool for the detection and visualization of annotated and potential alternative polyadenylation events in downstream 3'-UTR of genes among two different biological conditions. It is used for the detection and visualization of 3'-UTR alternative polyadenylation with RNA-seq and 3'-end-seq data.
    • PTNet (RRID:SCR_022975) is a graph-based learning model for protein expression estimation by considering the miRNA-mRNA interactions. It estimates protein levels by considering miRNA-mRNA interaction network, mRNA expression, and miRNA expression.
    • OmicsGAN(RRID:SCR_022976) is a software generative adversarial network to integrate two omics data and their interaction network to generate one synthetic data corresponding to each omics profile that can result in better phenotype prediction. It is used to capture information from interaction networks as well as two omics datasets and fuse them to generate synthetic data with better predictive signals.
    • mtradeR (RRID:SCR_022977) is a software R package that implements the Joint model with Matching and Regularization (JMR) and simulation pipeline. It is used to test the association between taxa and disease risk, and adjusted for correlated taxa screened by pre-selection procedure in abundance and prevalence, individually.
    • ISLET (RRID:SCR_022978) is a software R package to conduct signal deconvolution for general omics data. It can estimate individual specific and cell type-specific reference panels, when there are multiple samples observed from each subject. It can solve reference panels on an individual basis. It can conduct tests to identify cell type-specific differential expression genes.
    • CoffeeProt (RRID:SCR_022256) is an open-source software tool for the correlation and functional enrichment of proteome-wide systems genetics. It analyzes genetic variants associated with protein networks and phenotypic traits. It uses proteomics data to perform correlation network analysis and annotates protein-protein interactions, subcellular localizations, and drug associations.

 

Events in January 2023

Jan. 08, 2023

Application deadline: 2023 Biomedical Data Science Innovation Lab

The goal of the 2023 Biomedical Data Science Innovation Lab (BDSIL) is to foster the formation of new interdisciplinary collaborations which will generate creative strategies on the use of data science approaches for predicting secondary health effects of the COVID-19 pandemic. The Lab is intended to bring together quantitative and biomedical researchers, with expertise from the mathematical, statistical, basic science, and clinical biomedical fields, to address topics in biomedical data science critical to modeling and predicting when, where, and in what form such secondary effects on public health will occur. To be eligible to apply, candidates must be in the quantitative and data sciences or biomedical fields, specifically involving epidemiology, and at the late-stage post-doctoral and early-stage junior faculty levels.

More information: https://www.innovation.lab.virginia.edu/2023-lab


Jan. 11, 2023

Vanderbilt Diabetes Center Diabetes research virtual seminar "“Cardiometabolic Disease: Pathophysiology, Natural History, and Clinical Implications”

Presenter: W. Timothy (Tim) Garvey, MD, MACE, Distinguished University Professor, Department of Nutrition Sciences, University of Alabama at Birmingham, Director, UAB Diabetes Research Center.

More information: https://diabetes-virtual-seminar.org/


Jan. 13, 2023

dkNET Office Hours - "Are You Ready for 2023: New NIH Data Management and Sharing Mandates"

For all proposals submitted on/after January 25 2023, NIH will require the sharing of data from all NIH funded studies. Do you have appropriate data management practices and sharing plans in place to meet these requirements? Have questions or need some help? Join the dkNET office hours to learn about NIH’s policy (NOT-OD-21-013) and resources that could help.

Date/Time: Friday, January 13, 2023, 11 am - 12 pm PT (2 pm - 3 pm ET)

More information: https://dknet.org/about/blog/2535

Jan. 17-18, 2023

CureGN Analytic Workshop

WORKSHOP GOALS: 1) Increase visibility of CureGN 2) Increase the capacity to access and analyze CureGN data among the research community 3) Increase bandwidth for publications and ancillary studies 4) Support career development. -RSVP OR CONTACT CUREGN-PROJECTMANGEMENT@ARBORREASEARCH.ORG FOREXACT LOCATION AND LODGING DETAILS.
More information: https://assets.website-files.com/5e81f24f957e0a9938366a4c/6348019e64c74f97364a20ff_Advertisement%20-%20Analytic%20Workshop.pdf

Location:  Ann Arbor, MI, USA


Jan. 24-25, 2023

Generalist Repository Ecosystem Initiative (GREI) Workshop

dkNET Webinar: The Adaptive Immune Receptor Repertoire (AIRR)

Presenters: TBA

Abstract: TBA

Dial-in Information: https://uchealth.zoom.us/meeting/register/tZ0scuihrT8uGtZiOtklnOAtsoK4hFBsz5-u

Date/Time: Friday, January 27, 2023, 11 am - 12 pm PT

More information: https://dknet.org/about/webinar


Funding Opportunities Information and Deadlines in January 2023

Jan. 13, 2023

Funding Opportunity Letter of Intent Due: Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)

The DiabDocs program is now soliciting a second cycle of letters of intent for applications for a mentored career development program from a diverse group of early career physician scientists engaged in research relevant to type 1 diabetes (T1D) including basic, translational, clinical, epidemiology/biostatistical, informatics, health services or health policy projects. Awards will provide promising investigators the opportunity to be mentored in research-intensive settings at their home institutions to create the research foundation to compete successfully for NIH K08/23 or similar Career Development Awards. Successful applicants will be early career faculty with experience and training in relevant areas who have demonstrated skills and potential in research and articulate a strong commitment to an academic research career. Application Due Date: February 17, 2023.

More information: https://dknet.org/about/dknetnews/2505


Jan. 21, 2023

NIDDK Funding Opportunity Letter of Intent Due: Integrated Physiology of Exocrine and Endocrine Pancreas in Type 1 Diabetes (R01 - Clinical Trial Not Allowed)

This Funding Opportunity will support multi-disciplinary teams to examine interactions between exocrine and endocrine pancreas to support the study of T1D. The purpose of this opportunity is to encourage integrated study of the whole pancreas to enable characterization of direct and indirect crosstalk between exocrine and endocrine compartments, and identification of the mechanisms by which that crosstalk occurs and can be disrupted in T1D and other forms of diabetes. Development of assays or platforms to allow for broader investigation into these questions could also be supported.
Letter of Intent Deadline: January 21, 2023
Application Deadline: February 21, 2023
More information: https://dknet.org/about/dknetnews/2479


Jan. 28, 2023

NIDDK Funding Opportunity Letter of Intent Due: Collaborative Research Using Biosamples from Type 1 Diabetes Clinical Studies (R01 - Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) invites applications for studies of type 1 diabetes etiology and pathogenesis using data and samples from clinical trials and studies. This opportunity is intended to fund investigative teams collaborating to answer important questions about disease mechanisms leading to improved prevention of type 1 diabetes.
Letter of Intent Deadline: January 28, 2023 ; September 26, 2023
Application Deadline: February 28, 2023 ; October 26, 2023
More information: https://grants.nih.gov/grants/guide/rfa-files/rfa-dk-22-021.html

Jan. 28, 2023

Kidney X Competition Submission Due: Artificial Kidney Prize, Phase 2, Track Two

People with kidney diseases need kidney replacement therapies that increase survival and improve quality of life. Innovation is urgently needed – but also incredibly difficult: a functioning kidney is built from over 26 different cell types that seamlessly integrate to maintain homeostasis. KidneyX aims to increase the options for treating people with kidney diseases—including the creation of a bioartificial kidney. The first phase of the Artificial Kidney Prize (awarded in Fall 2021) sought solutions to enable and advance the functionality, effectiveness, and/or reliability of artificial kidneys. This phase of the Artificial Kidney Prize aims to accelerate the development of an artificial kidney from the regenerative medicine, cellular engineering, tissue engineering, systems biology, and synthetic biology communities.
Track One: Accelerating the Prototype Bioartificial Kidney
Track Two: Components and Tools that Enable the Development of an Artificial Kidney
Track One Submission Due: October 28, 2022
Track Two Submission Due: January 28, 2023
More information: https://www.kidneyx.org/akp

Jan. 28, 2023

NIDDK Funding Opportunity Letter of Intent Due: Clinical, Behavioral, and Physiological Studies of Open- and Closed-loop Platforms: Toward Personalized, Fully Automated, Accessible Systems (R01 Clinical Trial Required)

The purpose of this funding opportunity announcement (FOA) is to promote clinical research using current and emerging technologies to address barriers that limit progress toward physiological pancreatic hormone replacement open- and closed-loop systems. It will support research to: 1) test and improve the safety, reliability, and clinical efficacy of these technologies; 2) address behavioral/psychosocial factors that play a role in the usability and acceptance of these systems and validation of measures that may be used as outcomes for the demonstration of efficacy and benefit; 3) test these technologies in subpopulations of patients not usually included in clinical trials who may benefit the most from their use; 4) test these technologies in individuals who are underserved or in low income and/or racial and ethnic minority groups, and better understand disparities in the use and adoption of these systems; and 5) use the technologies as tools to advance understanding of glucose regulation and its pathophysiology in patients with type 1 diabetes (T1D) including counter-regulation and impaired awareness of hypoglycemia. Research goals include improved metabolic control with decreased glycemic excursions, prevention of acute and chronic complications, and improved quality of life in patients with diabetes and their caregivers. Only human studies will be considered responsive to this FOA, applications involving animal or in vitro studies are not responsive to this FOA.
Letter of Intent Deadline(s): January 28, 2023; September 26, 2023
Application Deadline(s): February 28, 2023; October 26, 2023
More information: https://grants.nih.gov/grants/guide/rfa-files/rfa-dk-22-020.html

Jan. 28, 2023

NIDDK Funding Opportunity Letter of Intent Due: NIDDK Investigator Award to Support Mentoring of Early Career Researchers from Diverse Backgrounds

The purpose of the NIDDK Investigator Award to Support Mentoring of Early Career Researchers from Diverse Backgrounds is to provide protected effort and resources to established, NIDDK-funded, mentors to provide high quality mentoring to graduate students and postdoctoral fellows from diverse backgrounds, including those from underrepresented groups (see, e.g., Notice of NIH’s Interest in Diversity). Program Directors/Principals Investigators (PD/PIs) (mentors) must be conducting research that falls within the missions of the NIDDK and such research programs should serve as the framework around which mentoring activities are constructed. PD/PIs/applicants must have a demonstrable track record of mentoring early career researchers from diverse backgrounds, including those from underrepresented groups. This Funding Opportunity Announcement (FOA) is designed specifically for candidates proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial. Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor.
Letter of Intent Due Date: January 28, 2023;
Application Due Date: February 28, 2023.

More information: https://dknet.org/about/dknetnews/2538


Jan. 31, 2023

NIDDK Funding Opportunity: NIDDK Education Program Grants (R25 Clinical Trial Not Allowed) Application Due Date

Description: The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH.  The overarching goal of this R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nation’s biomedical, behavioral and clinical research needs.

To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on:

  • Courses for Skills Development
  • Research Experiences

These courses for skill development and research experiences must fall within NIDDK's mission areas. NIDDK supports research training skill development and research experiences on diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases. 

More information: https://grants.nih.gov/grants/guide/pa-files/par-21-034.html


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