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dkNET community events and announcements in March, 2020

Dear dkNET Community,

dkNET provides updates on activities of interest to the NIDDK-supported community. You could keep up to date on these activities through our Twitter feed @dkNET_info, through our Community Calendar, or through dkNET e-mail list. If you have an event or funding opportunities you'd like to advertise, please contact us info_at_dknet.org.


dkNET News

Funding opportunity:

  • 2020 dkNET Summer of Data Student Internship To support researchers with the use of on-line resources, the 6-week dkNET Summer of Data Student Internship program provides students an opportunity to utilize the dkNET tools and resources in a research project and to provide feedback on their experience to the dkNET team. Students will learn best practices to enhance rigor and reproducibility and learn the basics of good data management by following the FAIR (Findable, Accessible, Interoperable, Reusable) data principles. dkNET will award a $1,000 scholarship to a limited number of high school, undergraduate or graduate (Masters or PhD) students who are working in a research lab during summer 2020. Awards will be determined by a competitive selection process. Application due date: April 17, 2020.

New publication:

  • Congratulations to our colleague, Dr. Chun-Nan Hsu from the dkNET team, for publishing a new paper "Comparing the Use of Research Resource Identifiers and Natural Language Processing for Citation of Databases, Software, and Other Digital Artifacts" in the special issue of Computer in Science & Engineering (CiSE) on Software and Data Citation! Check out the paper here: https://ieeexplore.ieee.org/document/8897047
  • Congratulations to our collaborators, Drs. Ochsner and McKenna, from the Signaling Pathways Project (SPP) team for publishing a new paper "No Dataset Left Behind: Mechanistic Insights into Thyroid Receptor Signaling Through Transcriptomic Consensome Meta-Analysis" in the journal Thyroid! Download the paper at https://www.liebertpub.com/doi/10.1089/thy.2019.0307

New research tools added:

  • Vivli (RRID:SCR_018080) is an independent, non-profit organization that has developed global data-sharing and analytics platform to promote, coordinate, and facilitate scientific sharing and reuse of clinical research data through creation and implementation of sustainable global data-sharing enterprise. Vivli's focus is on sharing individual participant-level data from completed clinical trials. Users can search listed studies, request data sets from data contributors, aggregate data, or share data of their own.
  • CircaDB (RRID:SCR_018078) is a database of mammalian circadian gene expression profiles. It works with link outs to Wikipedia, HomoloGene, Refseq, etc., and is an open-source database of circadian transcriptional profiles from time course expression experiments from mice and humans.
  • CRISPy-web (RRID:SCR_017970) is a web tool to design sgRNAs for CRISPR applications. It is  based on CRISPy to design sgRNAs for any user-provided microbial genome, and is implemented as a standalone web application for Cas9 target prediction.

dkNET upcoming webinar:

Save the date! Our next dkNET webinar: The Human Islet Research Network (HIRN) will be on Friday, March 13, 2020 at 11 am PT. Join us for a webinar presented by Dr. John Kaddis to learn more about this useful resource! 


Events in March, 2020

Mar. 01-05, 2020

New Insights into the Biology of Exercise

Exercise and regular physical activity are widely recognized to be important for maintaining overall health and wellness. Furthermore, exercise has been proven to be an effective therapy for the prevention and treatment of a variety of diseases including diabetes, obesity, cardiovascular disease, and cancer. The physiological response of selected tissues, such as skeletal muscle, heart, liver, adipose, and brain to exercise has been studied to varying degrees in healthy and unhealthy individuals; however, the cellular and molecular mechanisms underlying the acute responses and training adaptations to exercise remain poorly defined. The study of exercise is not a new field but is receiving increased interest because of the many health-promoting benefits of regular aerobic and resistance exercise. This conference includes selected speakers who can present new findings related to the response of multiple organs/tissues (skeletal muscle, liver, adipose tissue, heart, vascular, brain) to exercise in both animal models and humans. The overarching goals for the conference are to 1) encourage discussion of the integrative multiple organ response to exercise, 2) encourage discussion and integration of basic and translational research, and 3) provide an environment for investigators to network and initiate new collaborations.

Location:  Keystone, CO 80435, USA

More information:  http://www.keystonesymposia.org/20Q7

Mar. 13, 2020

dkNET Webinar: Human Islet Research Network (HIRN)

The Human Islet Research Network (HIRN) was established in 2014 to help organize and support collaborative research related to the loss of functional beta cell mass in Type 1 Diabetes (T1D). Join us for a webinar presented by Dr. John Kaddis to learn more about this useful resources!

More information:  https://dknet.org/about/webinar

Mar. 16, 2020

Late breaking abstract submission deadline: American Diabetes Association 80th Scientific Sessions

The Scientific Sessions offers researchers and health care professionals an amazing opportunity to share ideas and learn about the significant advances in diabetes research, treatment, and care. Over the course of five days, attendees will receive exclusive access to more than 2,800 original research presentations, take part in provocative and engaging exchanges with leading diabetes experts, and expand professional networks with over 12,000 attendees from around the world.

More information:  https://professional.diabetes.org/scientific-sessions

Mar. 22-26, 2020

A Gut-Systemic Perspective for Metabolic Disease

Changes of the microbiome and nutrient sensing within the gut alter whole-body glucose and energy homeostasis. The underlying mechanism and the therapeutic potential of such metabolic regulation in diabetes, obesity, and related disorders remain largely unexplored. This Keystone Symposia conference aims to progressively highlight a spectrum of basic and translational investigations and discoveries that first focus on microbial-host interaction and nutrient sensing mechanisms. Other sessions focus on the interaction between the gut microbiome and nutrient sensing pathways as well as how these pathways could be targeted by small molecules and/or immunological responses within the gut to impact systemic organs and whole-body metabolic homeostasis. In summary, we anticipate this conference will foster interactions between the basic, translational, clinical and pharmaceutical researchers and promote collaborative work aimed at realizing the therapeutic potential of targeting the gut microbiota-nutrient sensing axis for the treatment of metabolic disorders.

Location:  Santa Fe, NM, USA

More information:   http://www.keystonesymposia.org/20C3


Mar. 28-31, 2020

ENDO 2020 [Cancelled]

With a long-standing reputation for high-quality clinical, basic, and translational programing, ENDO provides a unique opportunity for you to gain further knowledge not only in your area of specialty, but also in other related areas. This year’s program features outstanding plenaries, enhanced scientific and clinical knowledge, the latest clinical practice guidelines, and exposure to new techniques and methodology. Attend ENDO 2020 to take advantage of unparalleled opportunities for collaboration. Connect with thought leaders in the field, exchange ideas and information, earn CME credits, and gain insights from the latest trends and advancements in hormone health.

Location:  San Francisco, CA, USA

More information:    https://www.endocrine.org/endo2020



Funding opportunities information and deadlines in March, 2020

Mar. 01, 2020

Funding Opportunity Application Deadline: MMPC MICROMouse Program

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$75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more] [less]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more] [less] [less] [less] [less]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more] [less]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more] [less] [less]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more] [less]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more] [less] [less] [less]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more] [less]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more] [less] [less]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more] [less]The MMPC MICROMouse Program is a competitive grants program awarding up to $75,000 (total costs) for one year to fund research projects that have the potential to enhance and advance the miss ...[more]


Mar. 01, 2020

NIDDK Funding Opportunity Letter of Intent Due Date: Discovery of Early Type 1 Diabetes Disease Processes in the Human Pancreas [HIRN Consortium on Beta Cell Death and Survival (CBDS)] (U01 Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) requests applications to explore human pancreatic tissues for the discovery of specific signaling or processing pathways that may contribute to the asymptomatic phase of T1D, the discovery of early biomarkers of T1D pathogenesis, the development of diagnostic tools for the detection and staging of early T1D in at-risk or recently-diagnosed individuals, and/or the identification and biological validation of therapeutic targets for the development of preventative or early treatment strategies. Successful applicants will join the Consortium on Beta Cell Death and Survival (CBDS), whose mission is to better define and detect the mechanisms of beta cell stress and destruction central to the development of T1D in humans, with­ the long-term goal of protecting the residual beta cell mass in T1D patients as early as possible in the disease process, and of preventing the progression to autoimmunity. The CBDS is part of a collaborative research framework, the Human Islet Research Network (HIRN, https://hirnetwork.org/), whose overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This FOA will only support studies with a primary focus on increasing our understanding of human disease biology (as opposed to rodent or other animal models). This FOA will not accept applications proposing a clinical trial.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-024.html

Mar. 02, 2020

NIH Funding Opportunity Application Due Date: 4DN Organization and Function in Human Health and Disease (U01 Clinical Trial Not Allowed)

To support projects that apply new or existing tools to monitor and/or manipulate the 4D nucleome in the context of human health and disease. Any human disease or biological process relevant to NIH’s mission may be proposed including environmental exposures (e.g. addictive substances, toxins, psychosocial stress), or studies across development or lifespan. Other relevant timeframes may include but are not limited to: circadian rhythms, fasting and feeding cycles, reproductive cycles, and sleep/wake cycles.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-20-005.html

Mar. 02, 2020

NIH Funding Opportunity Application Due Date: Funding Opportunity: Letter of Intent Due: New Investigator Projects on 4DN Organization and Function in Human Health and Disease (U01 Clinical Trial Not Allowed)

To support projects from scientists who are in the early stages of establishing an independent research career that apply new or existing tools to monitor and/or manipulate the 4D nucleome (4DN) in the context of human health and disease. Any human disease or biological process relevant to NIH’s mission may be proposed including environmental exposures (e.g. addictive substances, toxins, psychosocial stress), or studies across development or lifespan. Other relevant time frames may include but are not limited to: circadian rhythms, fasting and feeding cycles, reproductive cycles, and sleep/wake cycles.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-20-006.html

Mar. 03, 2020

NIH Funding Opportunity Application Due Date: Tissue Mapping Centers for the Human BioMolecular Atlas Program (U54 Clinical Trial Not Allowed)

The purpose of this Funding Opportunity Announcement (FOA) is to establish state-of-the-art Tissue Mapping Centers (TMCs) that will generate high-resolution, high-content, multiscale maps of non-diseased human organs and systems. Centers will be expected to integrate and optimize all parts of the data generation pipeline, from tissue collection and preservation through to data integration, analysis and interpretation. Centers will also be expected to work closely with the other funded projects as part of the Human BioMolecular Atlas Program to catalyze development of a framework for mapping the human body in 3D with high resolution.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-20-002.html

Mar. 03, 2020

NIH Funding Opportunity Application Due Date: Transformative Technology Development for the Human BioMolecular Atlas Program (UG3/UH3 Clinical Trial Not Allowed)

The purpose of this Funding Opportunity Announcement (FOA) is to solicit transformative technologies that will significantly expand throughput, multiplexing and discrimination of biomolecules in human tissues for comprehensive mapping of individual cells and their context in human tissues. This FOA supports the accelerated proof-of-principle demonstration and validation of promising tools, techniques and systems that can be integrated, scaled and applied to multiple human tissues, particularly for characterizing functional modifications, lipids and the extracellular environment. The initial two-year UG3 phase will support accelerated development and demonstration of feasibility of these emerging, high impact technologies. The subsequent two-year UH3 phase will support validation in human tissues, optimization, scale-up, and generation of data. Funded projects will be expected to work closely as part of the Human BioMolecular Atlas Program to catalyze development of a framework for 3D mapping the human body with high resolution.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-20-001.html

Mar. 03, 2020

NIDDK Funding Opportunity Application Due Date: NIDDK Central Repositories Non-renewable Sample Access (X01 Clinical Trial Not Allowed)

The NIDDK Central Repositories house valuable biological samples and data from numerous major clinical studies. This initiative allows investigators to apply for access to non-renewable samples from one or more of these studies. Information about the samples available can be found at https://repository.niddk.nih.gov. Applicants must provide a report from the NIDDK Central Repositories documenting sample availability.

More information:  https://grants.nih.gov/grants/guide/pa-files/PAR-19-319.html

Mar. 07, 2020

NIDDK Funding Opportunity Letter of Intent Due Date: Development and Integration of Novel Components for Open and Closed Loop Hormone Replacement Platforms for T1D Therapy (R01 Clinical Trial Optional)

This Funding Opportunity Announcement (FOA) encourages applications from institutions/organizations proposing original research addressing barriers that limit progress toward effective open- and closed-loop glucose control systems. Proposed research should tackle important obstacles at the level of sensing, hormone formulation and delivery, self-management decision support systems, and/or design of automated controllers/algorithms able to manage an integrated platform. This research may contribute to development of affordable and user friendly technologies to improve glucose control in patients with type 1 diabetes.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-029.html

Mar. 09, 2020

NIDDK Funding Opportunity Letter of Intent Due Date: Support for Small Business Innovation Research (SBIR) to Develop New Technologies for Development and Integration of Novel Components for Open and Closed Loop Hormone Replacement Platforms for T1D Therapy (R43/R44 Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications for funding to perform research leading to the development of new approaches to create devices/components with enhanced accuracy and less patient burden that will represent real advancements regarding safety and effectiveness of glucose control technologies and their integration into open and closed loop hormone replacement systems.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-027.html

Mar. 09, 2020

NIDDK Funding Opportunity Letter of Intent Due Date: Support for Small Business Innovation Research (SBIR) to Development and Testing of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/R44 Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications for funding to perform research leading to the development of novel and supportive technologies for the improvement of cell replacement interventions using novel methods, biomaterials and devices for type 1 diabetes (T1D) treatment.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-028.html

Mar. 09, 2020

NIDDK Funding Opportunity Letter of Intent Due Date: Clinical Trials to Test Artificial Pancreas Device Systems in Populations Challenging to Manage Type 1 Diabetes (T1D) (U01 Clinical Trial Required)

This FOA will support the conduct of clinical trials designed to test the clinical safety and efficacy of artificial pancreas (AP) device systems with the objective of improving glycemic control, reducing acute complications and improving quality of life in people with difficult to control T1D when using standard of care therapies.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-036.html

Mar. 13, 2020

NIDDK Funding Opportunity Application Due Date: Type 1 Diabetes in Acute Pancreatitis Consortium - Clinical Centers (T1DAPC-CCs) (U01 Clinical Trial Optional)

This Funding Opportunity Announcement (FOA) invites U01 applications for the establishment of a clinical consortium, composed of one Data Coordinating Center (DCC) and up to 10 Clinical Centers (CC), to conduct studies on diabetes mellitus, with an emphasis on Type 1 diabetes (T1D), that occurs after or as a consequence of one or more episodes of acute pancreatitis. The Consortium will form multi-disciplinary teams composed of members from the CCs and DCC to undertake a prospective longitudinal observational study of the occurrence of diabetes that occurs during an acute pancreatitis episode or subsequently, with an emphasis on type 1 diabetes (T1D). The study will be designed to gain insight into the incidence, clinical evolution, etiology, type and pathophysiology of the T1D and other forms of diabetes that occurs during or after one or more episodes of acute pancreatitis. The teams will also undertake studies on the identification of immune and genetic risk factors and biomarkers which predict the development of T1D in a racially, ethnically, and geographically diverse population of subjects who have impaired glucose tolerance or diabetes mellitus after one or more episodes of acute pancreatitis due to various identifiable etiologies. Applications for the Data Coordinating Center (DCC) will be submitted in response to a separate FOA: RFA-DK-19-023: Type 1 Diabetes in Acute Pancreatitis Consortium Data Coordinating Center (T1DAPC-DCC) (U01 Clinical Trial Optional). To achieve the goal of a comprehensive characterization of diabetes with an emphasis on T1D that results or occurs after acute pancreatitis, each CC should include researchers and clinicians with multi-disciplinary expertise. CCs will be expected to share results freely within Consortium and to develop trans-consortium collaborative projects that make use of the combined expertise and technological capabilities present in all of the CCs. In addition, a major collaborative effort within the Consortium will be the establishment of an annotated repository of bio-specimens (e.g., blood, saliva, urine, pancreatic and duodenal juice, stools and when feasible pancreatic tissue) to allow for the identification and validation of biomarkers for risk stratification, early detection, and to inform the development of future treatment strategies to prevent or reverse T1D after acute pancreatitis.

More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-022.html

Mar. 13, 2020

NIDDK Funding Opportunity Application Due Date: Type 1 Diabetes in Acute Pancreatitis Consortium - Data Coordinating Center (T1DAPC-DCC) (U01 Clinical Trial Optional)

This Funding Opportunity Announcement (FOA) invites U01 applications for the establishment of a clinical consortium, the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC), composed of one Data Coordinating Center (DCC) and up to 10 Clinical Centers (CC), to conduct studies on Type 1 diabetes mellitus (T1D) that occurs after or as a consequence of one or more episodes of acute pancreatitis. Applications for the Clinical Centers (CC) are submitted in response to a separate FOA: RFA-DK-19-022  : Type 1 Diabetes in Acute Pancreatitis Consortium Clinical Centers (T1DAPC-CC) (U01 Clinical Trial Optional). The applicant for the Data Coordinating Center (DCC) must have experience serving as the DCC for studies on complex, clinical conditions, like the occurrence of diabetes mellitus (DM) after or as a consequence of one or more episodes of acute pancreatitis. The Consortium will form multi-disciplinary teams composed of members from the CCs and the DCC to undertake a prospective longitudinal observational study of the occurrence of diabetes that occurs during an acute pancreatitis episode or subsequently, with an emphasis on type 1 diabetes (T1D). The study will be designed to gain insight into the incidence, clinical evolution, etiology, type and pathophysiology of the T1D and other forms of diabetes after acute pancreatitis. The Consortia will also undertake studies on the identification of immune and genetic risk factors and biomarkers which predict the development of T1D in a racially, ethnically, and geographically diverse population of subjects who have recovered from one or more episodes of acute pancreatitis due to various identifiable etiologies. The DCC will provide overall project coordination, administration, quality control, data management and biostatistical support.

More information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-023.html


Mar. 17, 2020

NIH Funding Opportunity Application Due Date: 4DN Centers for Data Integration\, Modeling and Visualization (UM1 Clinical Trial Not Allowed)

The purpose of this FOA is to solicit applications for research projects to generate reference datasets and to create navigable maps for the study of the spatial and temporal organization of the nucleus, using genomic and imaging data as well as newly developed visualization and integrative analysis tools.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-20-004.html

Mar. 17, 2020

NIH Funding Opportunity Application Due Date: Real Time Chromatin Dynamics and Function (U01 Clinical Trial Not Allowed)

To support the development and application of tools that would enable the monitoring in real-time of the dynamic three-dimensional structure of mammalian genomes and provide insight into how organizing components of 4D genome architecture affect biological processes in live cells.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-20-003.html

Mar. 20, 2020

NIH Funding Opportunity Application Due Date: MoTrPAc Phase 2 Animal Studies (U01 Clinical Trial Not Allowed)

The purpose of this FOA is to invite applications for additional Preclinical Animal Study Sites (PASS) to join the Molecular Transducers of Physical Activity Consortium (MoTrPAC; http://commonfund.nih.gov/MolecularTransducers). Awards made through this FOA will support investigations into the molecular mechanisms of molecules mobilized in response to exercise identified by the existing MoTrPAC PASS and Chemical Analysis Sites (http://MoTrPAC-data.org). The new PASS members will use MoTrPAC data to conduct detailed mechanistic studies to explore the functions, sources, and target tissues of molecules that transduce the beneficial effects of physical activity that have been identified in MoTrPAC.Awardees from this FOA will represent an integral component of the MoTrPAC and must work collaboratively within the consortium to plan and execute this study to begin characterizing the molecular mechanisms of molecules identified in the 'molecular map' that underlie the beneficial effects of physical activity. The product will be a publicly available data resource that will enhance and accelerate subsequent mechanistic research on overall physiology and diseases and/or conditions affected by physical activity.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-20-009.html

Mar. 25, 2020

NIDDK Funding Opportunity Application Due Date: New Investigator Gateway Awards for Collaborative T1D Research (R03 Clinical Trial Not Allowed)

The New Investigator Gateway Award in T1D Research is designed to ensure that a robust pipeline of talented new investigators will continue to embark on successful careers in T1D research. In addition to providing support for preliminary research, the Gateway program provides an opportunity for new Program Directors/Principal Investigators (PD/PIs) to pursue their studies within the intellectual environment of a select number of large, ongoing collaborative research programs. Embedding awardees within an established scientific framework in each of these consortia will provide unique opportunities for New and Early Stage Investigators to increase their understanding of key questions in the field, to network, and to establish unique and potentially long-lasting collaborations that will propel their careers forward. It is anticipated that the Gateway award will providethe support needed to enhance the success of future R01 submissions from New Investigators interested in pursuing careers in T1D research.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-026.html

Mar. 26, 2020

NIDDK Funding Opportunity Application Due Date: Mechanisms Underlying the Contribution of Type 1 Diabetes Disease-associated Variants (R01 Clinical Trial Not Allowed)

This Funding Opportunity Announcement (FOA) encourages applications from integrative teams and individual investigators for large-scale complex multi-disciplinary Functional Genomics Projects (FGPs) to determine the contributions and mechanisms underlying the contribution of associated variants for type 1 diabetes (T1D). Genome-wide association studies (GWAS) and other genomic studies of T1D have found many variants that are statistically associated with disease risk or disease protection, but they have not clearly shown which variants in genomic elements cause these effects or how they result in differences in function. Applications submitted to this RFA will systematically identify causal variants and effector transcripts associated with all known T1D risk variants, verify the role of downstream effector transcripts, build network models that explain their role(s) in T1D. These biological insights could lead to the development of reliable biomarkers and effective strategies for screening and disease prevention, rational drug design, and better tailored therapies.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-020.html

Mar. 26, 2020

NIDDK Funding Opportunity Application Due: Treating Diabetes Distress to Improve Glycemic Outcomes in Type 1 Diabetes (R01 Clinical Trial Required)

This FOA seeks applications for clinical trials testing interventions targeting diabetes distress in individuals with type 1 diabetes and/or their caregivers, with the goal of understanding whether lowering diabetes distress will improve glycemic control and quality of life. Given the clinical care recommendation that screening for diabetes distress take place in the context of medical care, applications should reflect a practical team approach to screening and treatment that could realistically occur in a clinical setting.

More information:  https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-19-021.html

Mar. 31, 2020

NOSI Application Due Date: Notice of Special Interest (NOSI): Availability of Administrative Supplements to Accelerate Dissemination of Emerging Glycoscience Tools through Collaborations Between Developers and Early Adopters

The NIH Common Fund Glycoscience Program (CF-GSP) supports the development of methodologies, tools, and resources to simplify and expand the synthesis of large libraries of glycans; for glycan identification, tracking, manipulation, and functional analysis; and informatics to integrate gene, protein, and glycan datasets. Access to robust glycan libraries and tools to study N- and O-glycosylation, proteoglycans, polysaccharides, and glycolipids are expected to facilitate studies of the roles these molecules play in normal cellular processes and in disease. To encourage broad adoption of CF-GSP tools/technologies, the Common Fund will support administrative supplements to NIH-supported investigators who are NOT part of the Glycoscience program and NOT established glycoscientists. These will be one-year administrative supplements to existing NIH awards for: (1) Non-specialists who need access to glycobiology tools (2) Engaging core facilities to adopt glyco tools/technologies developed by the CF-GSP (3) Intensive collaboration between CF-GSP technology/methodology developers and non-glycoscientist adopters (4) Validation and refinement of CF-GSP technologies and methods (5) Faster demonstration of effectiveness of CF-GSP technologies and methods (6) Feedback for documentation and tutorials related to the technologies and methods developed by the CF-GSP.

More information: https://grants.nih.gov/grants/guide/notice-files/NOT-RM-20-003.html


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