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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11567272
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2016-12-13)
Alternate IDs: 11567272
Notes: The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Mecp2 into Sprague Dawley embryos. This mutant rat has a knockout of the methyl CpG binding protein 2 (Mecp2). Horizon Discovery
Proper citation: RRID:RGD_11567272 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11553883
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2017-01-26)
Alternate IDs: 11553883
Notes: ZFN system was used to introduce a mutation in the Rbm20 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 58-bp deletion in Exon 2 of the Rbm20 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_11553883 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790721
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals; Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 12790721
Notes: ZFN system was used to introduce a mutation in the Serpinc1 gene of SS.BN-(D13Rat151-D13Rat197)/Mcwi rat embryos. The resulting mutation is a 29-bp deletion in Exon 1 of the Serpinc1 gene.
Proper citation: RRID:RGD_12790721 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11568646
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-05)
Alternate IDs: 11568646
Notes: The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Met into Sprague Dawley embryos. The resulting mutation was a 5-bp deletion in exon 6 of Cntnap2. Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot. Horizon Discovery
Proper citation: RRID:RGD_11568646 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11568058
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2018-03-22)
Alternate IDs: 11568058
Notes: The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Nrxn1 into Sprague Dawley embryos. This mutant rat has a 16-bp deletion in exon1 resulting in knockout of Nrxn1. Horizon Discovery
Proper citation: RRID:RGD_11568058 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790659
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2017-02-20)
Alternate IDs: 12790659
Notes: This strain was produced by injecting TALENs targeting the Il2rg gene into Crl:SD rat embryos. The resulting mutation is a 2-bp deletion in exon 2.
Proper citation: RRID:RGD_12790659 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11568062
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2016-12-13)
Alternate IDs: 11568062
Notes: The ZFN mutant rat strain was produced by injecting zinc finger nuclease targeting rat Pten into Sprague Dawley embryos. This mutant rat has a 7-bp deletion in exon7 resulting in knockout of Pten. Horizon Discovery
Proper citation: RRID:RGD_11568062 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790662
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 12790662
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Mb gene of WKY/NCrl rat embryos. The resulting mutation is a 25-bp deletion in the exon 2 of the Mb gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_12790662 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12790944
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 12790944
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Sik2 gene of WKY/NCrl rat embryos. The resulting mutation is a 5-bp deletion in exon 4 of the Sik2 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_12790944 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13628730
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 13628730
Notes: TALEN targeting the 2nd exon of rat Il2rg gene was designed and mRNA coding these TALEN was microinjected into Crl:SD embyo.This strain carrying an 80 bp deletion generated a premature stop codon in the 3rd exon. No Il2rg protein was detected by western blot.
Proper citation: RRID:RGD_13628730 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12880026
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2017-05-01)
Alternate IDs: 12880026
Notes: This rat model carries a bi-allelic deletion of the amyloid precursor protein (APP) gene. Horizon Discovery
Proper citation: RRID:RGD_12880026 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13207509
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm; Cryorecovery (as of 2021-11-03)
Alternate IDs: 13207509
Notes: CRISPR/Cas9 system was used to introduce a mutation in the P2rx1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion in Exon 2 of the P2rx1 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13207509 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12905036
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-31)
Alternate IDs: 12905036
Notes: This model expresses cre-recombinase under the control of the endogenous 5 prime-hydroxytryptamine receptor 3A (5Ht3a) promoter enabling specific expression in 5Ht3a positive serotonergic neurons. This model possesses a targeted insertion of (T2A)-cre immediately before the translational stop in the open reading frame of the 5Ht3a gene. The 5Ht3a-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lines. Horizon Discovery
Proper citation: RRID:RGD_12905036 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904903
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-24)
Alternate IDs: 12904903
Notes: This ZFN model carries a 2 bp deletion within exon 3 of the Rag2 gene on chromosome 3. Homozygous Rag2 knockout rats display loss of RAG2 protein via Western blot. Homozygous Rag2 knockout rats show loss of B and T cells by FACS analysis. Horizon Discovery
Proper citation: RRID:RGD_12904903 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904902
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2017-05-24)
Alternate IDs: 12904902
Notes: This ZFN model carries a 29 bp deletion within exon 2 of the Rag1 gene on chromosome 3. Rag1 knockout rats lack mature B and T lymphocytes. Horizon Discovery
Proper citation: RRID:RGD_12904902 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=11553908
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 11553908
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Trpc6 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 3-bp substitutions to generate P112Q in Exon 2 of the Trpc6 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_11553908 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12904733
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Embryo (as of 2017-05-19)
Alternate IDs: 12904733
Notes: This ZFN induced knockout model contains 11 bp bi-allelic deletion within exon 1 of the Slc22a1. The homozygous knockout rats display total loss of protein via Western blot. Horizon Discovery
Proper citation: RRID:RGD_12904733 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13207529
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 13207529
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Spp1 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 5-bp deletion in Exon 3 of the Spp1 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13207529 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12902621
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-06-20)
Alternate IDs: 12902621
Notes: This ZFN model contains a monoallelic deletion of the Bdnf gene, encoding for the nerve growth factor protein BDNF. Homozygous animals carrying the Bdnf deletion are postnatal lethal. Reductions of BDNF have been observed in patients with Alzheimer's disease (AD), and this model may be useful for understanding the role of BDNF in AD. Horizon Discovery
Proper citation: RRID:RGD_12902621 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=12902625
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-05-09)
Alternate IDs: 12902625
Notes: This ZFN model contains a 20-bp deletion within the Nr1i2 gene. No induction of Cyp3a1 in the model. Horizon Discovery
Proper citation: RRID:RGD_12902625 Copy
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