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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.

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  • Species:rattus norvegicus (facet)

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Organism Name Proper Citation Species Synonyms Notes Phenotype Affected Gene Genomic Alteration Catalog Number Background Database Database Abbreviation Availability Source References Alternate IDs Record Last Update Mentions Count
WKY-Col4a5em3Matsu
 
Resource Report
Resource Website
RRID:RGD_329845600 Rattus norvegicus Genome editing was performed using the rGONAD method to produce three different lines of KO rats due to three different genome mutations thus different in protein expression predication. The genetic background is WKY/NCrlCrlj (Charles River Laboratories Japan) (RGD:61119). Tandem STOP codons were designed to integrate into 27 bases after the first ATG in the rat Col4a5 gene This em3 mutant carries a deletion of 56 base pairs containing the first methioine. Col4α5 em3 ratshave urinary protein and hematuria from early on, and males begin to die at 18 weeks of age and all die by 28 weeks of age. National BioResource Project for the Rat in Japan 329845600 mutant Rat Genome Database (RGD) RGD Unknown 329845600 2026-08-29 11:50:00 0
LEW-Chrna3em1Mcwi
 
Resource Report
Resource Website
RRID:RGD_10054373 Rattus norvegicus CRISPR/Cas9 system was used to introduce a mutation in the Chrna3 gene of LEW/NCrl rat embryos.The resulting mutation is a 1-bp (G) insertion in the Chrna3 gene. Contact MCW rat distribution at [email protected] 10054373 mutant Rat Genome Database (RGD) RGD Unknown (as of 2018-10-22) 10054373 2026-08-29 11:50:00 0
SD-Pde3aem3Bdr
 
Resource Report
Resource Website
RRID:RGD_155631298 Rattus norvegicus The rat mutant was generated by pronuclear microinjection of Sprague-Dawley rat zygotes with a mixture of Cas9/Cas9 system to target the catalytic domain in the rat Pde3a gene. The model has a carriesa CGT to TGD missense mutation and results in R862C substitutions in the protein 155631298 mutant Rat Genome Database (RGD) RGD Unknown 155631298 2026-08-29 11:49:59 0
SD-Ahrem1Iexas+/-
 
Resource Report
Resource Website
RRID:RGD_401940197 Rattus norvegicus The Ahr heterozygous rats were created using CRISPR/Cas9 gene editing to delete 10 bp of exon 2 of Ahr in Sprague Dawley rats . 401940197 mutant Rat Genome Database (RGD) RGD Unknown 401940197 2026-08-29 11:50:00 0
SS-Xdhem1Mcwi+/-
 
Resource Report
Resource Website
RRID:RGD_405849408 Rattus norvegicus CRISPR/Cas9 system was used to introduce a 7-bp deletion in exon 4 of rat Xdh gene in the SS/JrHsdMcwi embryos. This is a heterozygous strain which has decreased Xdh protein detected in the kidney cortex tissue as compared to the wild type littermate at 6-week old. Contact MCW rat distribution at [email protected] 405849408 mutant Rat Genome Database (RGD) RGD Unknown 405849408 2026-08-29 11:50:00 0
SD-Mpoem1Mcwi
 
Resource Report
Resource Website
RRID:RGD_401717572 Rattus norvegicus CRISPR/SpCas9 system using sgRNA targeting the sequence CAGGGCCACGTGCAGATAGTCGG was used to introduce an 11-bp deletion (rn7: chr10:72,595,923-72,595,933) in exon 4 of the Mpo gene in Crl:SD strain rats. 401717572 mutant Rat Genome Database (RGD) RGD Live Animals (as of 2023-08-07) 401717572 2026-08-29 11:50:00 0
CD-Ctnsem4Vjupk
 
Resource Report
Resource Website
RRID:RGD_155630635 Rattus norvegicus The mutant rat was produced by injecting Crl:CD(SD) zygotes with gRNA +Cas9 ribonucleoprotein complex targeting exon 3 of rat Ctns. The founder of this strain possessed a 7-bp deletion which results in frameshift and pre-mature stop truncated protein. 155630635 mutant Rat Genome Database (RGD) RGD Unknown 155630635 2026-08-29 11:49:59 0
WN
 
Resource Report
Resource Website
RRID:RGD_70458 Rattus norvegicus Heston in 1942 from Wistar stock of Nettleship, This WN is the parent to WN substrains maintained in other institutions. 70458 inbred Rat Genome Database (RGD) RGD Unknown 70458 2026-08-29 11:50:00 0
SD-Ahrem1Iexas-/-
 
Resource Report
Resource Website
RRID:RGD_401940195 Rattus norvegicus The homozygous knockout rats were created using CRISPR/Cas9 gene editing to delete 10 bp of exon 2 of Ahr in Sprague Dawley rats . 401940195 mutant Rat Genome Database (RGD) RGD Unknown 401940195 2026-08-29 11:50:00 0
SS-Mmp2em1Mcwi+/+
 
Resource Report
Resource Website
RRID:RGD_5688032 Rattus norvegicus ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. (null) (null) 5688032 mutant Rat Genome Database (RGD) RGD Unknown 5688032 2026-08-29 11:50:00 0
SD-Gcdhem1Dba
 
Resource Report
Resource Website
RRID:RGD_10759544 Rattus norvegicus this strain was produced by CRISPR/Cas9 system. The resulting knock-in mutation is R411W in exon 11 of the GCDH gene. 10759544 mutant Rat Genome Database (RGD) RGD Unknown 10759544 2026-08-29 11:50:00 0
ZSF1-Leprfa/cp/Crl
 
Resource Report
Resource Website
RRID:RGD_401960101 Rattus norvegicus This F1 obese model was developed by crossing rat strains with two separate leptin receptor mutations (fa and facp), In Charles River, they mate a Heterozygous ZDF (fa/+) with a Homozygous SHHF (cp/cp).This mating of ZDF and SHHF parent can produce obese ZSF1 (having fa and cp mutation from both parents) or lean ZSF1 (having just one copy of mutated Lepr, either cp or fa). The obese F1 develop insulin resistance, hyperglycaemia, and mild hypertension Charles River Laboratories 401960101 hybrid Rat Genome Database (RGD) RGD Unknown 401960101 2026-08-29 11:50:00 0
SD-Tg(Myh6-cre)Lizh
 
Resource Report
Resource Website
RRID:RGD_329969882 Rattus norvegicus The heart-specific cre expression plasmid (alpha-MHC-Cre) was produced by inserting the cre coding sequence downstream of the a-MHC (Mgh6) promoter in the a-MHC expression vector. The a-MHC-Cre transgenic rat was generated by microinjection of linearized alpha-MHC-Cre plasmid to Sprague Dawley embryos. 329969882 transgenic Rat Genome Database (RGD) RGD Unknown 329969882 2026-08-29 11:49:59 0
SD-Trim44em1Lizh
 
Resource Report
Resource Website
RRID:RGD_329969883 Rattus norvegicus A pair of synthetic oligonucleotides for sgRNA (sgRNA1, CCTTGCCGCTTTAAGTGACTC; sgRNA2, CCATGTTGGGAGCATTGCCTA) were annealed and then cloned into the pUC57-sgRNA expression vector, and the floxed plasmid donor was cloned into the pGSI plasmid. Both the Cas9 and sgRNA expression plasmids were linearized and used as templates for in vitro transcription. A mixture of the donor vector (4 ng/ul), Cas9 mRNA (25 ng/ul), and sgRNAs (10 ng/ul each) was microinjected into both the cytoplasm and male pronucleus of the fertilized eggs. The injected zygotes were then transferred to pseudopregnant SD rats, which then carried them to parturition. This is called conditional knockout Trim44 (Trim44 cKO). 329969883 mutant Rat Genome Database (RGD) RGD Unknown 329969883 2026-08-29 11:50:00 0
SD-Fahem3McwiIl2rgem2McwiRag1em6Mcwi
 
Resource Report
Resource Website
RRID:RGD_401824639 Rattus norvegicus Produced by injection of CRISPR/Cas9 targeting the genomic sequence GGTGAGATCCTTTGAAAAGG in Rag1 into double homozygous embryos with knockout of Fah and Il2rg produced following multiple generations of intercrossing strains SD-Il2rgem2Mcwi (RGDID:10002794) and SD-Fahem3Mcw (RGDID: 10002791). The resulting CRISPR-induced mutation in Rag1 deletes 25-bp (rn7: chr3:87,923,384-87,923,408) and inserts 17 bp (ACCCTAAACAGCTGTGC) for a net 8-bp deletion. availability contact: [email protected] 401824639 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2025-11-22) 401824639 2026-08-29 11:50:00 0
WIC;WDB-Kiss1tm1Nurep
 
Resource Report
Resource Website
RRID:RGD_329848995 Rattus norvegicus The kisspeptin gene (Kiss1) is knocked out conditonally by the Cre recombinase. This strain was generated by K.I. Maeda (The University of Tokyo), H. Tsukamura, Y. Uenoyama, N. Inoue (Nagoya University), and M. Hirabayashi (National Institute for Physiological Sciences) for the purpose of producing conditional knockout rats of the Kiss1 gene in the hypothalamus. The targeting vector (loxP, Kiss1[exons 2 and 3], PGK promoter-neo, loxP) was introduced by electroporation targeting the Kiss1 gene in ES cells (WDB/Nips-ES1/Nips). Crossed with and maintained by the Wistar-Imamichi rats (Iar:Wistar-Imamichi, Institute for Animal Reproduction). National BioResource Project for the Rat in Japan 329848995 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2023-06-07) 329848995 2026-08-29 11:50:00 0
LE-Tg(Drd2-cre)487-3Koba
 
Resource Report
Resource Website
RRID:RGD_329848998 Rattus norvegicus This strain is established by injection of modified BAC (cre gene was inserted into the exon 2 of rat Drd2 gene) into Long-Evans rat's fertile eggs. Detailed information of BAC: Drd2, CH230-11B15 from the CHORI-230 Female Brown Norway rat BAC Library (BACPAC Resources Center, Children?s Hospital Oakland Research Institute)" National BioResource Project for the Rat in Japan 329848998 transgenic Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2023-06-07) 329848998 2026-08-29 11:50:00 0
WIC.WDB-Kiss1tm1(tdTomato)Nurep
 
Resource Report
Resource Website
RRID:RGD_329848994 Rattus norvegicus Kiss1 knockout rats were generated by K.I. Maeda (The University of Tokyo), H. Tsukamura, Y. Uenoyama, N. Inoue (Nagoya University), and M. Hirabayashi (National Institute for Physiological Sciences). The targeting vector (tdTomato/puromycin N-acetyl transferase) was introduced by electroporation targeting the Kiss1 gene in ES cells (WDB/Nips-ES1/Nips). Crossed with and maintained by the Wistar-Imamichi rats (Iar:Wistar-Imamichi, Institute for Animal Reproduction). National BioResource Project for the Rat in Japan 329848994 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2023-06-21) 329848994 2026-08-29 11:50:00 0
CD-Slc30a10em1Sommu
 
Resource Report
Resource Website
RRID:RGD_401795484 Rattus norvegicus Exon 1 of Slc30a10 was targeted using CRISPR/Cas9 in the Crl:CD(SD) embryos . A mosiac founder that transmitted a 248 bp deletion in exon 1 of Slc30a10 leading to an out of frame mutation after amino acid 22 was bred to a CD rat to select for the above deletion and establish the line. The strain will be deposited to RRRC. 401795484 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2023-09-11) 401795484 2026-08-29 11:50:00 0
SD.SD-Fahem3McwiIl2rgem2McwiRag1em6Mcwi/Mcwi
 
Resource Report
Resource Website
RRID:RGD_401824640 Rattus norvegicus This model was made by taking RGD:401824639 (Fah, Il2rg, and Rag1 triple knockout model) and backcrossing to Crl:SD, then intercrossing multiple generations again until all three gene alleles were homozygous again. Availability contact: [email protected] 401824640 congenic Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2023-09-18) 401824640 2026-08-29 11:50:00 0

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