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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=53621137
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals (as of 2024-01-10)
Alternate IDs: RGD_53621137, 53621137, RRRC_868, RRRC_0868, RRRC_00868
Notes: The CRISPR/Cas9 system was injected to the Crl:CD(SD)embryo to induce the knock-in Cre-ERT2 cassette at the 3' end of Wnt1 gene linked by 2A peptide. This model is used to lineage tracing of neural crest cells by tissue specific expression of creERT2 Rat Resource and Research Center
Proper citation: RRID:RRRC_00868 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=7245494
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2019-02-05)
Alternate IDs: RGD_7245494, 7245494, RRRC_633, RRRC_0633, RRRC_00633
Notes: Strain carries a transgene expressing human TDP43 with the M337V mutation under control of a tTA-dependent promoter (TRE). When mated to a second transgenic strain (RRRC:632) that carries a tetracycline-controlled transactivator driven by the mouse choline acetyltransferase (Chat) promoter, the expression of mutant TDP43 in Chat-expressing motor neurons in the double transgenic rats can be induced by withdrawal of doxycycline. Rat Resource and Research Center
Proper citation: RRID:RRRC_00633 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=7245488
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2019-02-05)
Alternate IDs: RGD_7245488, 7245488, RRRC_632, RRRC_0632, RRRC_00632
Notes: Rats express a mouse tetracycline-controlled transactivator (tTA) driven by the mouse choline acetyltransferase (Chat) promotor. When mated to a second transgenic strain (RRRC:00633) that carries a target gene (TDP43) under the regulation of a tetracycline response element (TRE), the expression of TDP43 in Chat-expressing motor neurons in the double transgenic rats can be induced by withdrawal of doxycycline. Rat Resource and Research Center
Proper citation: RRID:RRRC_00632 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2306062
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: RGD_2306062, 2306062, RRRC_273, RRRC_0273, RRRC_00273
Notes: Developed by the DEPOSITOR National BioResource Project for the Rat in Japan, Rat Resource and Research Center
Proper citation: RRID:RRRC_00273 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2304206
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: RGD_2304206, 2304206, RRRC_300, RRRC_0300, RRRC_00300
Notes: DsRed2/GFP double-reporter transgenic rat driven under a ubiquitous CAG promoter. In this system, DsRed2 expression was replaced with GFP expression after Cre recombinase-mediated excision established at Jichi Medical School. National BioResource Project for the Rat in Japan, Rat Resource and Research Center
Proper citation: RRID:RRRC_00300 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2304210
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: RGD_2304210, 2304210, RRRC_260, RRRC_0260, RRRC_00260
Notes: This transgenic strain expresses the DsRed2 (DsRed: red fluorescent protein) liver-specific under the direction of the mouse albumin enhancer/promoter established at Jichi Medical School. National BioResource Project for the Rat in Japan, Rat Resource and Research Center
Proper citation: RRID:RRRC_00260 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=1554310
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: RGD_1554310, 1554310, RRRC_294, RRRC_0294, RRRC_00294
Notes: lacZ cDNA was inserted in the EcoRI site of the pCAGGS expression vector. This DNA was microinjected into the DA/Crlj. The expression of the transgene was determined by beta-gal staining. National BioResource Project for the Rat in Japan, Rat Resource and Research Center
Proper citation: RRID:RRRC_00294 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2292530
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: RGD_2292530, 2292530, RRRC_320, RRRC_0320, RRRC_00320
Notes: This transgenic strain carries a random insertion of a construct containing mouse Oct 4 promoter and DsRed. This results in DsRed expression in germ and early embryonic cells. Rat Resource and Research Center
Proper citation: RRID:RRRC_00320 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2292528
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: RGD_2292528, 2292528, RRRC_283, RRRC_0283, RRRC_00283
Notes: F344 embryos were microinjected with a DNA construct containing human amyloid precursor protein with Swedish variant (APPswe; K670N/M671L) under control of platelet-derived growth factor-B (PDGF-b promoter) as a promoter Rat Resource and Research Center
Proper citation: RRID:RRRC_00283 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155641251
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals (as of 2022-11-04)
Alternate IDs: RGD_155641251, 155641251, RRRC_946, RRRC_0946, RRRC_00946
Notes: The human ACE2 gene was placed under control of the synthetic CAG promoter which allows ubiquitous expression of the gene. Based on droplet digital PCR analysis, the strain carries only 1 copy of the transgene. The integration site is unknown. These rats express the human ACE2 gene. The encoded protein is a functional receptor for the spike glycoprotein of several human coronaviruses including SARS-CoV-2, the causative agent of coronavirus disease-2019 (COVID-19). Rat Resource and Research Center
Proper citation: RRID:RRRC_00946 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2292532
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo; Cryopreserved Sperm
Alternate IDs: RGD_2292532, 2292532, RRRC_277, RRRC_0277, RRRC_00277
Notes: F344 embryos were microinjected with human beta-C-terminal fragment of the amyloid protein Rat Resource and Research Center
Proper citation: RRID:RRRC_00277 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150523775
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Sperm; Cryorecovery (as of 2022-03-10)
Alternate IDs: RGD_150523775, 150523775, RRRC_916, RRRC_0916, RRRC_00916
Notes: This strain was made by pronuclear injection into LEW/Crl embryos. The embryos were co-injected with DNA fragments containing the HLA-B*2705 human gene and the human beta-2-microglobulin gene. The strain carries 20 copies of HLA-B*2705 and 15 copies of the human beta-2-microglobulin gene. Rat Resource and Research Center
Proper citation: RRID:RRRC_00916 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=150523778
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Sperm; Cryorecovery (as of 2022-03-10)
Alternate IDs: RGD_150523778, 150523778, RRRC_917, RRRC_0917, RRRC_00917
Notes: This strain carries 35 copies of genomic human B2-microglobulin gene. When crossed with the 21-3 line (RRRC:00 916), the F1 males develop a spontaneous disease mimicking human spondyloarthritis. Rat Resource and Research Center
Proper citation: RRID:RRRC_00917 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9588570
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: RGD_9588570, 9588570, RRRC_766, RRRC_0766, RRRC_00766
Notes: The transgene contains reporter rat expressing eGFP in cFos expressing cells Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00766 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=2305976
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Embryo
Alternate IDs: RGD_2305976, 2305976, RRRC_339, RRRC_0339, RRRC_00339
Notes: This is the strain expresses human Amyloidogenic transthyretin (ATTR) V30M driven by the mouse albumin enhancer/promoter, established at Jichi Medical School. National BioResource Project for the Rat in Japan, Rat Resource & Research Center
Proper citation: RRID:RRRC_00339 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155260364
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Cryopreserved Sperm (as of 2022-10-06)
Alternate IDs: RGD_155260364, 155260364, RRRC_970, RRRC_0970, RRRC_00970
Notes: rat strain in which the rat Cyp3a1 gene (Cyp3a23-3a1, RGD:628626) was inactivated by insertion of a human CYP3A4 minigene (Cyp3A4*) and the linked rat Cyp3a2 locus was simultaneously mutated by CRISPR-mediated indel introduction. Strain contains Indel 8 at the Rat 3A2 locus (55 kb away), The CYP3A4 minigene included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance. Strain contains and Active Genetic cassette which encodes a gRNA targeting the Rat 3A1 and 3A2 translation initiation site. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951
URL: URL: Doi:10.1101/2022.08.30.505951 Rat Resource and Research Center
Proper citation: RRID:RRRC_00970 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9588572
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: RGD_9588572, 9588572, RRRC_730, RRRC_0730, RRRC_00730
Notes: The transgene contains BAC transgenic using rat DAT promoter to express Cre recombinase in dopaminergic neurons Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00730 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=155641245
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2023-12-13)
Alternate IDs: RGD_155641245, 155641245, RRRC_975, RRRC_0975, RRRC_00975
Notes: Targeted knock-in adding a T2A-iCre to the Oprm1 (mu opioid receptor) in this cre recombinase reporter SD rat Rat Resource and Research Center
Proper citation: RRID:RRRC_00975 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=9588585
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: RGD_9588585, 9588585, RRRC_736, RRRC_0736, RRRC_00736
Notes: The transgene contains Cre recombinase expressed from cFos promoter and controllable by Tet activator/repressor Optogenetics and Transgenic Technology Core, Rat Resource and Research Center
Proper citation: RRID:RRRC_00736 Copy
http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=1358303
Source Database: Rat Resource and Research Center (RRRC)
Genetic Background: transgenic
Availability: Unknown
Alternate IDs: RGD_1358303, 1358303, RRRC_645, RRRC_0645, RRRC_00645
Notes: This transgenic strain carries a mouse rhodopsin gene that bears a termination codon at residue 334, which encodes a C-terminal truncated opsin protein. Retinal Degeneration Rat Model Resource ,Rat Resource and Research Center
Proper citation: RRID:RRRC_00645 Copy
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