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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://www.wormbase.org/db/get?name=WBStrain00060882
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: unknown
Source References: PMID:37565483
Synonyms: aSi31 II; unc-119(ed3) III
Notes: aSi31 [lox2272::Cbr-unc-119(+)::lox2272::mec-7p:: NLS::GCaMP7f::ras-2-CAAX::SL2::mScarlet-I::ras-2-CAAX] II. mec-7 promoter driving membrane-localized expression of GCaMP7f in ALM, PLM, AVM & PVM neurons. Reference: Ding J, et al. GE (Bethesda). 2023 Sep 30;13(10):jkad183. doi: 10.1093/g3journal/jkad183. PMID: 37565483.
Proper citation: RRID:WB-STRAIN:WBStrain00060882 Copy
http://www.wormbase.org/db/get?name=WBStrain00060886
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: unknown
Source References: PMID:37565483
Synonyms: aSi36 II; unc-119(ed3) III.
Notes: aSi36 [lox2272::Cbr-unc-119(+)::lox2272::mec-7p::GCaMP7f::SL2::mScarlet-I] II. mec-7 promoter driving expression of GCaMP7f in ALM, PLM, AVM & PVM neurons. Reference: Ding J, et al. GE (Bethesda). 2023 Sep 30;13(10):jkad183. doi: 10.1093/g3journal/jkad183. PMID: 37565483.
Proper citation: RRID:WB-STRAIN:WBStrain00060886 Copy
http://www.wormbase.org/db/get?name=WBStrain00060876
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: unknown
Source References: PMID:37565483
Synonyms: aSi8 II; unc-119(ed3) III.
Notes: aSi8 [lox2272::Cbr-unc-119(+)::lox2272::mec-7p:: NLS::GCaMP7s::egl-13-NLS::SL2::NLS::mScarlet-I:: egl-13-NLS] II. mec-7 promoter driving nuclear-localized expression of GCaMP7f in ALM, PLM, AVM & PVM neurons. Reference: Ding J, et al. GE (Bethesda). 2023 Sep 30;13(10):jkad183. doi: 10.1093/g3journal/jkad183. PMID: 37565483.
Proper citation: RRID:WB-STRAIN:WBStrain00060876 Copy
http://www.wormbase.org/db/get?name=WBStrain00034612
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; heIs105 IV.
Alternate IDs: WB-STRAIN:SV1361, CGC_SV1361
Notes: heIs105 [rps-27::loxP::NLS::mCherry::let858 UTR::loxP::NLS::GFP::let-858 UTR + unc-119(+)] IV. Strain is viable at 15-25 C. heIs105 carries a read-out construct which allows the visualization of the CRE lox mediated recombination by a switch from red to green. Reference: Ruijtenberg S & van den Heuvel S. Cell. 2015 Jul 16;162(2):300-13.
Proper citation: RRID:WB-STRAIN:WBStrain00034612 Copy
http://www.wormbase.org/db/get?name=WBStrain00034613
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; heSi141 X.
Alternate IDs: WB-STRAIN:SV1438, CGC_SV1438
Notes: heSi141 [hlh-8(short)::FLAG::CRE::tbb-2 + unc-119(+)] X. Strain is viable at 15-25 C, but non-tissue specific recombination is observed more frequently in other tissues at higher temperatures (25C). Expression of CRE recombinase in the mesoblast lineage driven by the hlh-8 promoter. Reference: Ruijtenberg S & van den Heuvel S. Cell. 2015 Jul 16;162(2):300-13.
Proper citation: RRID:WB-STRAIN:WBStrain00034613 Copy
http://www.wormbase.org/db/get?name=WBStrain00034614
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; heSi142 X.
Alternate IDs: WB-STRAIN:SV1439, CGC_SV1439
Notes: heSi142 [elt-2::FLAG::CRE::tbb-2 + unc-119(+)] X. Expression of CRE recombinase in the intestine driven by the elt-2 promoter. Strain is viable at 15-25 C, but non-tissue specific recombination is observed more frequently in other tissues at higher temperatures (25C). Reference: Ruijtenberg S & van den Heuvel S. Cell. 2015 Jul 16;162(2):300-13.
Proper citation: RRID:WB-STRAIN:WBStrain00034614 Copy
http://www.wormbase.org/db/get?name=WBStrain00034617
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; heIs145 IV
Alternate IDs: WB-STRAIN:SV1450, CGC_SV1450
Notes: heIs145 [rps-27::loxP::NLS::mCherry::let858 UTR::eft-3::tagBFP::tbb-2 UTR::loxP::NLS::GFP::let-858 UTR + unc-119(+)] IV. Maintain at 15-25C. heIs145 expresses a read-out construct used to visualize CRE activity and specificity, and to test whether CRE expression is likely to induce loss of a gene of interest (tagBFP in this case) in a given tissue. Expression of CRE will result in a change from mCherry to GFP and loss of tagBFP expression in those cells where CRE is active. Reference: Ruijtenberg S & van den Heuvel S. Cell. 2015 Jul 16;162(2):300-13.
Proper citation: RRID:WB-STRAIN:WBStrain00034617 Copy
http://www.wormbase.org/db/get?name=WBStrain00034618
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: unknown
Source References: EMPTY
Synonyms: unc-119(ed3) III; heSi148 X.
Alternate IDs: WB-STRAIN:SV1461
Notes: heSi148 [myo-3::CRE::tbb-2 UTR + unc-119(+)] X. Inserted at ttTi14024. Maintain at 15-25C. Expression of CRE recombinase in differentiated body wall muscle cells driven by the myo-3 promoter. Reference: Ruijtenberg S & van den Heuvel S. Cell. 2015 Jul 16;162(2):300-13.|"No longer available from the CGC"
Proper citation: RRID:WB-STRAIN:WBStrain00034618 Copy
http://www.wormbase.org/db/get?name=WBStrain00034611
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: heSi101 I; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:SV1317, CGC_SV1317
Notes: heSi101 [tcc-1p::tcc-1::mCherry::tcc-1 3' UTR + Cbr-unc-119(+)] I. TCC-1::mCherry associates with the mitotic spindle, nuclear envelope, and plasma membrane. Reference: Berends CWH, et al. Mol Biol Cell. 2013 Jul;24(14):2201-15.|"no longer available from the CGC."
Proper citation: RRID:WB-STRAIN:WBStrain00034611 Copy
http://www.wormbase.org/db/get?name=WBStrain00034620
Source Database: WormBase (WB)
Affected Genes: WBGene00004203(swsn-1)|WBGene00006843(unc-119)
Genomic Alteration: WBGene00004203(swsn-1), WBGene00006843(unc-119)
Availability: available
Source References: PMID:32494730
Synonyms: unc-119(ed3) III; heIs105 IV; swsn-1(os22) heSi164 V; heSi141 X.
Alternate IDs: WB-STRAIN:SV1578, CGC_SV1578
Notes: heIs105 [rps-27::loxP::NLS::mCherry::let858 UTR::loxP::NLS::GFP::let-858 UTR + unc-119(+)] IV. heSi164 [rps-27::loxN::NLS::mCherry::let858 UTR::swsn-1p::swsn-1::unc-54 UTR::loxN::NLS::GFP::let-858 UTR + unc-119(+)] V. heSi141 [hlh-8(short)::FLAG::CRE::tbb-2 + unc-119(+)] X. Maintain the line at 15C and shift to 25C for mutant analysis. Expression of CRE recombinase in the mesoblast lineage driven by the hlh-8 promoter. heSi164 carries a swsn-1 rescue construct which ensures rescue of the temperature-sensitive swsn-1(os22) mutation. Upon expression of CRE (in this case in the mesoblast lineage) the swsn-1 gene will be excised, creating a mesoblast specific mutant of swsn-1. This recombination event can be visualized by a switch from red to green in those mesoblast cells in which swsn-1 was lost. The animals are healthy at 15C, but embryonic lethal and larval arrested at 23-25C. swsn-1(os22) causes mild overproliferation in the mesoblast lineage. The swsn-1 rescuing transgene is unable to rescue germline development of swsn-1(os22) mutants. Reference: Ruijtenberg S & van den Heuvel S. Cell. 2015 Jul 16;162(2):300-13.
Proper citation: RRID:WB-STRAIN:WBStrain00034620 Copy
http://www.wormbase.org/db/get?name=WBStrain00034678
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV. gtIs67.
Alternate IDs: WB-STRAIN:TG1756, CGC_TG1756
Notes: gtIs67 [pie-1p::GFP(lap)::sld-5 + unc-119(+)]. ltIs37 [pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034678 Copy
http://www.wormbase.org/db/get?name=WBStrain00034671
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV; gtIs60.
Alternate IDs: WB-STRAIN:TG1749, CGC_TG1749
Notes: gtIs60 [pie-1p::GFP(lap)::orc-1 + unc-119(+)]. ltIs37 [pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034671 Copy
http://www.wormbase.org/db/get?name=WBStrain00034673
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV; gtIs62.
Alternate IDs: WB-STRAIN:TG1751, CGC_TG1751
Notes: gtIs62 [pie-1p::GFP(lap)::cdc-6 + unc-119(+)]. ltIs37 [pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034673 Copy
http://www.wormbase.org/db/get?name=WBStrain00034675
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV; gtIs64.
Alternate IDs: WB-STRAIN:TG1753, CGC_TG1753
Notes: gtIs64 [pie-1p::GFP(lap)::mcm-3 + unc-119(+)]. ltIs37 [(pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034675 Copy
http://www.wormbase.org/db/get?name=WBStrain00034676
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV; gtIs65.
Alternate IDs: WB-STRAIN:TG1754, CGC_TG1754
Notes: gtIs65 [pie-1p::GFP(lap)::cdc-45 + unc-119(+)]. ltIs37 [pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034676 Copy
http://www.wormbase.org/db/get?name=WBStrain00034677
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ltIs37 IV; gtIs66.
Alternate IDs: WB-STRAIN:TG1755, CGC_TG1755
Notes: gtIs66 [pie-1p::GFP(lap)::div-1 + unc-119(+)]. ltIs37 [pie-1p::mCherry::his-58 + unc-119(+)] IV. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034677 Copy
http://www.wormbase.org/db/get?name=WBStrain00034686
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; gtIs2367/+.
Alternate IDs: WB-STRAIN:TG2367, CGC_TG2367
Notes: gtIs2367 [pie-1p::GFP(lap)::orc-5 + unc-119(+)]. Maintain by picking non-Unc. Reference: Sonneville R, et al. J Cell Biol. 2012 Jan 23;196(2):233-46.
Proper citation: RRID:WB-STRAIN:WBStrain00034686 Copy
http://www.wormbase.org/db/get?name=WBStrain00034663
Source Database: WormBase (WB)
Affected Genes: WBGene00000467(cep-1)|WBGene00006843(unc-119)
Genomic Alteration: WBGene00000467(cep-1), WBGene00006843(unc-119)
Availability: available
Source References: PMID:31717869, PMID:38483995
Synonyms: cep-1(lg12501) I; unc-119 (ed4) III; gtIs1[CEP-1::GFP + unc-119 (+)]
Alternate IDs: WB-STRAIN:TG12, CGC_TG12
Notes: gtIs1[CEP-1::GFP + unc-119(+)]. GFP expression in germ line of adult worms (20-40 hours post L4) in the late pacytene area in the nucleus. Also expression in alae and a few nuclei in the pharynx. Compound microscope needed to see staining.|"Reference WBPaper00058851 added based on published strain data identified by Textpresso literature search."
Proper citation: RRID:WB-STRAIN:WBStrain00034663 Copy
http://www.wormbase.org/db/get?name=WBStrain00034768
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ddIs153.
Alternate IDs: WB-STRAIN:TH243, CGC_TH243
Notes: ddIs153 [knl-1::TY1::EGFP::3xFLAG(92C12) + Cbr-unc-119(+)]. TY1::EGFP::3xFLAG tag inserted in frame at C-terminus of coding sequence by recombineering. Expression of transgene confirmed by GFP. References: Sarov M, et al. Cell. 2012 Aug 17;150(4):855-66. Strain was constructed as part of the Regulatory Element Project, part of modENCODE (URL: www.modencode.org)
Proper citation: RRID:WB-STRAIN:WBStrain00034768 Copy
http://www.wormbase.org/db/get?name=WBStrain00034762
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; ddIs144.
Alternate IDs: WB-STRAIN:TH233, CGC_TH233
Notes: ddIs144 [atn-1::TY1::EGFP::3xFLAG(92C12) + Cbr-unc-119(+)]. TY1::EGFP::3xFLAG tag inserted in frame at C-terminus of coding sequence by recombineering. Expression of transgene confirmed by GFP. References: Sarov M, et al. Cell. 2012 Aug 17;150(4):855-66. Strain was constructed as part of the Regulatory Element Project, part of modENCODE (URL: www.modencode.org)
Proper citation: RRID:WB-STRAIN:WBStrain00034762 Copy
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