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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
| Organism Name | Proper Citation | Species | Synonyms |
Notes |
Phenotype | Affected Gene | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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SS-Tg(CAG-Fh)A1Mcwi Resource Report Resource Website |
RRID:RGD_151893484 | Rattus norvegicus | This is a transgenic model created using Sleeping Beauty system. The transgenic animals are overexpressing fumarate hydratase (Fh) under the control of the ubiquitous CAG promoter in the Dahl salt-sensitive strain background. contact MCW Rat Distribution at [email protected] | 151893484 | transgenic | Rat Genome Database (RGD) | RGD | Live Animals; Cryopreserved Sperm (as of 2022-04-21) | 151893484 | 2026-09-05 06:52:44 | 0 | |||||
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SD;DA-Tg(Thy1-APP*)1Dspb Resource Report Resource Website |
RRID:RGD_38599241 | Rattus norvegicus | Mutant human amyloid beta (APP*) combined Thy1 promoter which is specifically expressed in neurons, was induced to ES cells from DA strain rats, and chimera rats obtained from the ES cells. The F1 rats were backcrossed with Crl:CD (SD) strain rats and F3 rats was deposited to NBRP. The expression levels of mutant human APP mRNA are different among Lines (12>1>14>6). National BioResource Project for the Rat in Japan | 38599241 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2020-09-16) | 38599241 | 2026-09-05 06:52:43 | 0 | |||||
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LE-Tg(Tac1-cre)4-1Koba Resource Report Resource Website |
RRID:RGD_38599247 | Rattus norvegicus | Background strain: Long-Evans rat (Iar:Long-Evans, RGD:18337282). This strain was established by injection of modified BAC (cre gene was inserted into the exon 2 of rat Tac1 gene) into Long-Evans rat's fertile eggs.This transgenic strain expresses Cre recombinase under the control of Tac1 promoter. The expression levels of Cre recombinase in LE-Tg(Tac1-cre)4-1Koba are higher than in LE-Tg(Tac1-cre)6-7Koba (RGD:38599245). National BioResource Project for the Rat in Japan | 38599247 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2020-09-16) | 38599247 | 2026-09-05 06:52:43 | 0 | |||||
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LE-Tg(Tac1-cre)6-7Koba Resource Report Resource Website |
RRID:RGD_38599245 | Rattus norvegicus | Background strain: Long-Evans rat (Iar:Long-Evans, RGD:18337282). This strain was established by injection of modified BAC (cre gene was inserted into the exon 2 of rat Tac1 gene) into Long-Evans rat's fertile eggs. This transgenic strain expresses Cre recombinase under the control of Tac1 promoter. The expression levels of Cre recombinase in LE-Tg(Tac1-cre)6-7Koba are lower than in LE-Tg(Tac1-cre)4-1Koba (RGD:38599247) National BioResource Project for the Rat in Japan | 38599245 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2020-09-16) | 38599245 | 2026-09-05 06:52:43 | 0 | |||||
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SD;DA-Tg(Thy1-APP*)12Dspb Resource Report Resource Website |
RRID:RGD_38599243 | Rattus norvegicus | Mutant human amyloid beta (APP*) combined Thy1 promoter which is specifically expressed in neurons, was induced to ES cells from DA strain rats, and chimera rats obtained from the ES cells. The F1 rats were backcrossed with Crl:CD (SD) strain rats and F3 rats was deposited to NBRP. The expression levels of mutant human APP mRNA are difficult among Lines (12>1>14>6). National BioResource Project for the Rat in Japan | 38599243 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2020-09-16) | 38599243 | 2026-09-05 06:52:43 | 0 | |||||
|
CD-Tg(RNECO-180E22)424Arno Resource Report Resource Website 1+ mentions |
RRID:RGD_155663366 | Rattus norvegicus | This transgenic model line 424 was made by injecting bacterial artificial chromosome (BAC) RNECO-180E22, into Crl:CD(SD) strain embryos. The BAC clone RNECO-180E22, a kind gift of Helen Skaletsky, is derived from Rattus norvegicus strain SHR chromosome Y. | 155663366 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 155663366 | 2026-09-05 06:52:45 | 1 | |||||
|
CD-Tg(RNECO-180E22)208Arno Resource Report Resource Website 1+ mentions |
RRID:RGD_155663365 | Rattus norvegicus | This transgenic model line 208 was made by injecting bacterial artificial chromosome (BAC) RNECO-180E22, into Crl:CD(SD) strain embryos. The BAC clone RNECO-180E22, a kind gift of Helen Skaletsky, is derived from Rattus norvegicus strain SHR chromosome Y. | 155663365 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 155663365 | 2026-09-05 06:52:45 | 1 | |||||
|
SD-Tg(Prp-DISC1)Uhg Resource Report Resource Website |
RRID:RGD_291492855 | Rattus norvegicus | Transgenic Sprague Dawley rats were generated by injecting the linearized fragment of the CosSHa.tet vector containing the full-length, non-mutant human DISC1 as transgene with the polymorphisms F607 and C704, under the control of the Syrian hamster prion protein promoter, into pronuclei of Sprague Dawley rats. | 291492855 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 291492855 | 2026-09-05 06:52:44 | 0 | |||||
|
SD-Tg(Ddx4-Cas9)SynblRrrc Resource Report Resource Website |
RRID:RGD_155260362 | Rattus norvegicus | rat strain designed to express Cas9 under the control of the rat Ddx4 (Vasa) regulatory elements while also retaining expression of Ddx4. The strategy entailed insertion of a P2A sequence followed by human-codon-optimized Cas9 coding sequences with nuclear localization signals near the C-terminus of the rat Ddx4 (Vasa) gene. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 RRRC | 155260362 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 155260362 | 2026-09-05 06:52:44 | 0 | |||||
|
SD-Tg(Sycp1-Cas9-eGFP)SynblRrrc Resource Report Resource Website |
RRID:RGD_155260361 | Rattus norvegicus | This project entailed generation of a novel rat strain in which a P2A-Cas9-T2A-EGFP coding sequence was inserted at the stop codon of the rat Sycp1 gene for co-expression of Cas9 and EGFP under the control of the Sycp1 regulatory elements. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 from RRRC. | 155260361 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2022-10-06) | 155260361 | 2026-09-05 06:52:44 | 0 | |||||
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SD-Tg(Cyp2e1-CYP2E1*-Cas9)SynblRrrc Resource Report Resource Website |
RRID:RGD_155260363 | Rattus norvegicus | rat strain in which the rat Cyp2e1 gene is humanized by insertion of a human CYP2E1 minigene (CYP2E1*) insert at the native start codon. The insert also included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance of the modified allele when crossed to a rat expressing Cas9 in the germline. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 URL: URL: Doi:10.1101/2022.08.30.505951 RRRC | 155260363 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2022-10-06) | 155260363 | 2026-09-05 06:52:44 | 0 | |||||
|
SD-Tg(Ddx4-Cas9)Synbl Resource Report Resource Website |
RRID:RGD_155260366 | Rattus norvegicus | rat strain designed to express Cas9 under the control of the rat Ddx4 (Vasa) regulatory elements while also retaining expression of Ddx4. The strategy entailed insertion of a P2A sequence followed by human-codon-optimized Cas9 coding sequences with nuclear localization signals near the C-terminus of the rat Ddx4 (Vasa) gene. Animals express Cas9 in the testis in the spermatogonial layer and in meiosis stages with 4N DNA content. Strain catalyzes high levels of Active Genetic Gene conversion when paired with certain Active Genetic cassettes. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 Donated to Rat Resource & Research Center | 155260366 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 155260366 | 2026-09-05 06:52:44 | 0 | |||||
|
SD-Tg(Cyp3a23-3a1-Cyp3A4*-Cas9)Synb Resource Report Resource Website |
RRID:RGD_155260368 | Rattus norvegicus | rat strain in which the rat Cyp3a1 gene (Cyp3a23-3a1, RGD:628626) was inactivated by insertion of a human CYP3A4 minigene (Cyp3A4*) and the linked rat Cyp3a2 locus was simultaneously mutated by CRISPR-mediated indel introduction. Strain contains Indel 8 at the Rat 3A2 locus (55 kb away), The CYP3A4 minigene included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance. Strain contains and Active Genetic cassette which encodes a gRNA targeting the Rat 3A1 and 3A2 translation initiation site. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 URL: URL: Doi:10.1101/2022.08.30.505951 Donated to Rat Resource & Research Center | 155260368 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2022-10-06) | 155260368 | 2026-09-05 06:52:44 | 0 | |||||
|
SD-Tg(Cyp2e1-CYP2E1*-Cas9)Synbl Resource Report Resource Website |
RRID:RGD_155260367 | Rattus norvegicus | rat strain in which the rat Cyp2e1 gene is humanized by insertion of a human CYP2E1 minigene (CYP2E1*) insert at the native start codon. The insert also included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance of the modified allele when crossed to a rat expressing Cas9 in the germline. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 URL: URL: Doi:10.1101/2022.08.30.505951 Donated to Rat Resource & Research Center | 155260367 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2022-10-06) | 155260367 | 2026-09-05 06:52:44 | 0 | |||||
|
SD-Tg(MECP2 )Chnsr Resource Report Resource Website |
RRID:RGD_155631285 | Rattus norvegicus | PAC671D9 (AF031078) DNA containing all the exons of human MECP2 was injected to SD embryos to generate MECP2 duplication rat. | 155631285 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 155631285 | 2026-09-05 06:52:44 | 0 | |||||
|
SD-Tg(Oprm1-icre)1Ottc Resource Report Resource Website |
RRID:RGD_155641245 | Rattus norvegicus | Targeted knock-in adding a T2A-iCre to the Oprm1 (mu opioid receptor) in this cre recombinase reporter SD rat This rat was produced by Optogenetics and Transgenic Technology Core and now cryopreserved at RRRC. | 155641245 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 155641245 | 2026-09-05 06:52:45 | 0 | |||||
|
CD-Tg(RNECO-180E22)733Arno Resource Report Resource Website |
RRID:RGD_155663367 | Rattus norvegicus | This transgenic model line 733 was made by injecting bacterial artificial chromosome (BAC) RNECO-180E22, into Crl:CD(SD) strain embryos. The BAC clone RNECO-180E22, a kind gift of Helen Skaletsky, is derived from Rattus norvegicus strain SHR chromosome Y. | 155663367 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 155663367 | 2026-09-05 06:52:45 | 0 | |||||
|
SD-Tg(Acr3-EGFP)Nips Resource Report Resource Website |
RRID:RGD_401799619 | Rattus norvegicus | This transgenic strain was created by intracytoplasmic sperm injection (ICSI) mediated DNA transfer. Linearized Acr3-EGFP plasmid DNA (Nakanishi et al., FEBS Lett. 1999; 0.1 micrograms/ml) is mixed with sperm heads of Slc:SD rats for 2 min. The sperm head is microinjected into ovulated oocytes of Slc:SD rat (RGD ID:12910483) and incubated overnight prior to embryo transfer to pseudopregnant females. Resultant pups are examined for correct gene-targeting by genomic PCR, and maintained by crossing the founder with Slc:SD rat. Section of Mammalian Transgenesis Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi 444-8787, Japan. or Division of Mammalian Embryology, Center for Stem Cell Biology and Regenerative Medicine, The Institute for Medical Science, The University of Tokyo, Tokyo108-8639, Japan. | 401799619 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Embryo; Cryopreserved Sperm (as of 2023-09-12) | 401799619 | 2026-09-05 06:52:45 | 0 | |||||
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SD-Tg(Myh6-cre)Lizh Resource Report Resource Website |
RRID:RGD_329969882 | Rattus norvegicus | The heart-specific cre expression plasmid (alpha-MHC-Cre) was produced by inserting the cre coding sequence downstream of the a-MHC (Mgh6) promoter in the a-MHC expression vector. The a-MHC-Cre transgenic rat was generated by microinjection of linearized alpha-MHC-Cre plasmid to Sprague Dawley embryos. | 329969882 | transgenic | Rat Genome Database (RGD) | RGD | Unknown | 329969882 | 2026-09-05 06:52:45 | 0 | |||||
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LE-Tg(Drd2-cre)487-3Koba Resource Report Resource Website |
RRID:RGD_329848998 | Rattus norvegicus | This strain is established by injection of modified BAC (cre gene was inserted into the exon 2 of rat Drd2 gene) into Long-Evans rat's fertile eggs. Detailed information of BAC: Drd2, CH230-11B15 from the CHORI-230 Female Brown Norway rat BAC Library (BACPAC Resources Center, Children?s Hospital Oakland Research Institute)" National BioResource Project for the Rat in Japan | 329848998 | transgenic | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2023-06-07) | 329848998 | 2026-09-05 06:52:45 | 0 |
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