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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
| Organism Name | Proper Citation | Species | Synonyms |
Notes |
Phenotype | Affected Gene | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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SHR-Zbtb16em1Ipcv+/- Resource Report Resource Website |
RRID:RGD_126848794 | Rattus norvegicus | TALEN was used to target Zbtb16 (Plzf )in the SHR and one founder with a deletion of G at position 93 of the coding sequence (c.93delG) was identified. That deletion resulted in a frameshift downstream glycine 31 (p.Gly31fs). The frameshift mutation caused the incorporation of 20 aberrant amino acids downstream of the deleted G, followed by a stop codon. The founder was bred with SHR to generate more heterozygous animals. The homozygous animals die perinatally because of multiple developmental abnormalities. | 126848794 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 126848794 | 2026-09-05 06:52:43 | 0 | |||||
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SD-Ighmem1Ang Resource Report Resource Website |
RRID:RGD_150523755 | Rattus norvegicus | The mutation in this rat strain (line 19) comprised a 64 bp deletion of the IgM CH1 domain and generation of a stop codon. This strain carries deletion in both alleles has truncated Cmu. | 150523755 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 150523755 | 2026-09-05 06:52:43 | 0 | |||||
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SD-Wfs1em3Ptsn Resource Report Resource Website |
RRID:RGD_149735338 | Rattus norvegicus | Rat Wfs1 exon 5-specific zinc-finger nucleases (ZNFs) and microinjection-ready mRNA were injected to embryos harvested from female Sprague-Dawley rats (Crl: CD(SD) )rats. Thereafter, microinjected egg cells were transferred to the oviduct of pseudopregnant Sprague-Dawley recipients.Three different Wfs1 mutant rat lines were created: Wfs1em1 ( Wfs1-ex5-KO232), Wfs1em2 (Wfs1-ex5-KO266) and Wfs1em3 (Wfs1-ex5-INS244). Wfs1em3 rats carry a substitution in exon 5 of the Wfs1 gene, which is predicted to result in a substitution of LQK (aa 224-226) into YCMNTI in the WFS1 protein. | 149735338 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 149735338 | 2026-09-05 06:52:43 | 0 | |||||
|
SS-Vwfem4Mcwi Resource Report Resource Website |
RRID:RGD_150429598 | Rattus norvegicus | The rat strain was created via CRISPR/Cas9 targeting the VWF gene in DahlSS/Mcw (SS/JrHsdMcwi ) rat embryos. The resulting rat strain has a 13bp deletion in the untranslated region of Exon 52 of the VWF gene (g.158491511 - 158491523 on chromosome 4, Assembly: mRatBN7.2) The 13-bp deletion happens to be in the region where the polyadenylation signal resides (AAUAAA). The resulting mRNA is not polyadenylated and has trouble with transport from the nucleus to the cytoplasm. The result is a phenotype that is similar to a Type I von Willebrand Disease, being a partial quantitative deficiency of the circulating VWF protein. Some mRNA must make it through to translation, because low levels of VWF protein are detectable via ELISA (<10%). Both homozygous pairs and heterozygous pairs were used for breeding. Rat Genetic Models, through Versiti Blood Research Institute | 150429598 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 150429598 | 2026-09-05 06:52:43 | 0 | |||||
|
SD-Bmpr2em1Ang+/- Resource Report Resource Website |
RRID:RGD_38501086 | Rattus norvegicus | BMPR2-deficient rats were generated by using zinc-finger nucleases (Sigma, St. Louis, MO). The mRNA encoding mRNA at 5 ng/μL encoding a pair of zinc-finger nucleases recognizing rat BMPR2 sequences was injected to the cytoplasm of Sprague-Dawley zygotes. A rat line with a heterozygous 140 base pairs deletion in the first exon (BMPR2Δ140Ex1/+ rats) was chosen for this study becauseit displayed an intense pulmonary vascular remodeling at 3 months of life that was absent in the wild-type littermates. | 38501086 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 38501086 | 2026-09-05 06:52:43 | 0 | |||||
|
LE-Fxn em1Fara-/+ Resource Report Resource Website |
RRID:RGD_152999001 | Rattus norvegicus | Exon 4 of the rat Fxn gene was targeted for homologous recombination to introduce loxP sites using CRISPR/Cas9 This strain has been deposited with RRRC. | 152999001 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 152999001 | 2026-09-05 06:52:43 | 0 | |||||
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SD-Disc1em1Rst Resource Report Resource Website |
RRID:RGD_125093746 | Rattus norvegicus | CRISPR/Cas9 system was used to introduce a 371-bp deletion of exon 2 in the rat Disc1 gene of one-cell Crl:SD embryos. This deletion caused non-sense mutation and early termination of translation. | 125093746 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 125093746 | 2026-09-05 06:52:43 | 0 | |||||
|
SD-Trpm4em1Sage Resource Report Resource Website |
RRID:RGD_150521556 | Rattus norvegicus | Trpm4 gene specific Zinc finger constructs directed against exons 18-19, which contain the coding sequence for TM3-5 and the pore region of the TRPM4 protein, were injected in zygotes from Sprague-Dawley rats. This mutant rat with a 514 bp deletion which includes completely removes exon 18 and a piece of exon 19 from the Trpm4 gene, plus the intron 18-19. The deletion was confirmed via genomic sequencing and western blotting. | 150521556 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 150521556 | 2026-09-05 06:52:43 | 0 | |||||
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F344-Ppargm1Kyo Resource Report Resource Website |
RRID:RGD_38676254 | Rattus norvegicus | By using ENU mutagenesis followed by MuT-POWER screening of the KURMA (Kyoto University Rat Mutant Archive) samples, the depositors generated a heterozygous PPARg mutant (Ppargmkyo/+) rat with a missense mutation (G488T p.C163F in Pparg1 or G578T p.C193F for Pparg2) in Pparg. The PpargG488T homozygous rats are embryonic lethal. Heterozygous Ppargmkyo/+ rats showed reduced fat mass with adipocyte hypertrophy and insulin resistance, which were highly predictable from known actions of Pparg agonists and phenotypes of patients with the PPARG mutation. National BioResource Project for the Rat in Japan | 38676254 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2020-09-16) | 38676254 | 2026-09-05 06:52:43 | 0 | |||||
|
F344-Hcn1em1Kyo Resource Report Resource Website |
RRID:RGD_38676253 | Rattus norvegicus | TALEN (Left: ttcagAATGATTCATGGG, Right : ACGCACTCTTCAAAGCTA) targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 7-bp deletion in the exon4 of Hcn1 gene: as a result of frameshift mutation, stop codon is produced. Decreased expression levels of Hcn1 gene and HCN1 protein. National BioResource Project for the Rat in Japan | 38676253 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2020-09-16) | 38676253 | 2026-09-05 06:52:43 | 0 | |||||
|
F344-Hcn1em2Kyo Resource Report Resource Website |
RRID:RGD_38676251 | Rattus norvegicus | TALEN (Left: ttcagAATGATTCATGGG, Right : ACGCACTCTTCAAAGCTA) targeting the exon4 of hyperpolarization-activated cyclic nucleotide-gated 1 channel (Hcn1) gene was designed and mRNA coding these TALEN was microinjected into F344/NSlc embyo. A 24-bp deletion in the exon4 of Hcn1 gene. It is predicted that 8 amino-acid deleted HCN1 protein is expressed. National BioResource Project for the Rat in Japan | 38676251 | mutant | Rat Genome Database (RGD) | RGD | Cryopreserved Sperm (as of 2020-09-16) | 38676251 | 2026-09-05 06:52:43 | 0 | |||||
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SD-Del(Yp)1Mcwi Resource Report Resource Website |
RRID:RGD_155663364 | Rattus norvegicus | CRISPR guide RNAs flanking Sry4a and Sry1 (Sry) on the Y-chromosome were injected into Crl:SD strain embryos. Chromosomal deletions have not been explicitly defined. | 155663364 | mutant | Rat Genome Database (RGD) | RGD | Live Animals (as of 2022-11-11) | 155663364 | 2026-09-05 06:52:45 | 0 | |||||
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SD-Spon2em1Holi Resource Report Resource Website |
RRID:RGD_329333019 | Rattus norvegicus | This Spon2 knockout mutant was produced by injecting TALENs targeting exon 2 of rat Spon2 into Sprague Dawley embryos. Founder #4-1 (a1) carrying a 22-bp deletion was chosen to produce heterozygous and homozygous rats. | 329333019 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 329333019 | 2026-09-05 06:52:44 | 0 | |||||
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SD-Ddah1em1Ywxu Resource Report Resource Website |
RRID:RGD_151347605 | Rattus norvegicus | CRISPR-Cas9 technique was used to generate DDAH1-/- rats on Sprague-Dawley background. Genome deletion in exon 1 was confirmed by PCR analysis with the primers:DDAH1-F (5'-GCGCTGCTCTCGGGAAGA-3') and DDAH1-R (5'-GGGTGATGAGGGCGGTCT-3'). | 151347605 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 151347605 | 2026-09-05 06:52:44 | 0 | |||||
|
SS-Chr 3BN.Il2rgem1Mcwi/Mcwi Resource Report Resource Website |
RRID:RGD_155791425 | Rattus norvegicus | The IL2Rg gene was targeted in the SS/JrHsdMcwi rat by TALEN injection into single-cell rat embryos. Once established, a homozygous (RGD:12790632) female rat from the SSIL2Rg line was intercrossed with a homozygous SS.BN3 (RGD:1358154) male to yield heterozygous SS.BN3IL2Rg offspring (F1), followed by brother-sister mating to yield homozygous SS. BN3IL2Rg offspring by the F3 generation. This strain is Immunodeficient Ilrg (X-SCID) mutant consomic line. | 155791425 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 155791425 | 2026-09-05 06:52:44 | 0 | |||||
|
SD-Bmal1em1Mcwi Resource Report Resource Website |
RRID:RGD_155598601 | Rattus norvegicus | CRISPR/Cas9 system was used to introduce a 58-base pair deletion in exon 6 in the rat Bmal1 gene of Crl:SD embryos. The deletion caused a premature stop codon in exon 6 resulting in a severe truncation of the Bmal1 protein. Contact MCW rat distribution at [email protected] | 155598601 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 155598601 | 2026-09-05 06:52:44 | 0 | |||||
|
SD-Pde6bem1Cgen Resource Report Resource Website |
RRID:RGD_155631289 | Rattus norvegicus | This mutant strain was generated by microinjecting CRISPRs/Cas9 system targeting rat Pde6b. Pde6b knock out rat was successfully created. Cyagen Biosciences Inc, Santa Clara, CA, USA | 155631289 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 155631289 | 2026-09-05 06:52:44 | 0 | |||||
|
CD-Ctnsem3Vjupk Resource Report Resource Website |
RRID:RGD_155630633 | Rattus norvegicus | The mutant rat was produced by injecting Crl:CD(SD) zygotes with gRNA +Cas9 ribonucleoprotein complex targeting exon 3 of rat Ctns. The founder of this strain possessed a 8-bp insertion which results in frameshift and pre-mature stop truncated protein. | 155630633 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 155630633 | 2026-09-05 06:52:44 | 0 | |||||
|
SD-Flnaem1Ang Resource Report Resource Website |
RRID:RGD_155631278 | Rattus norvegicus | This mutant strain was generated by electroporating rat zygotes with CRISPRs/Cas9 system targeting exon12 of rat Flna into Crl:SD embryo. This mutant strain carries P637Q knock in the gene. | 155631278 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 155631278 | 2026-09-05 06:52:44 | 0 | |||||
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F344-Txn1m1Kyo Resource Report Resource Website |
RRID:RGD_288084580 | Rattus norvegicus | This mutation Phe54Leu is an autosomal dominant mutation that appeared in a stock of F344/NSlc rats that had been mutagenized with N-ethyl-N-nitrosourea (ENU). Rats heterozygous for Txn1 (Txn1 /+) exhibited running seizures only in its juvenile stage. The rat called Adem rat, exhibited age dependent mitochondrial cytopathy (Adem). The rats were backcrossed for more than ten generations on the F344/NSlc inbred background to ensure other mutations induced by ENU was reduced. The causative gene was identified as a missense substitution (c. 160 T > C, p. Phe54Leu) in exon 3 of Txn1. | 288084580 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 288084580 | 2026-09-05 06:52:44 | 0 |
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