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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.

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Organism Name Proper Citation Species Synonyms Notes Phenotype Affected Gene Genomic Alteration Catalog Number Background Database Database Abbreviation Availability Source References Alternate IDs Record Last Update Mentions Count
SS-Prr5em1Mcwi
 
Resource Report
Resource Website
RRID:RGD_14398463 Rattus norvegicus CRISPR/Cas9 system was used to introduce a mutation in the Prr5 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 19-bp deletion in the exon 1 of the gene. Contact MCW rat distribution at [email protected] 14398463 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2019-04-19) 14398463 2026-09-05 06:52:42 0
F344-Phf24em2Kyo
 
Resource Report
Resource Website
RRID:RGD_38676450 Rattus norvegicus In 2013, F344/Stm female rat deleted 392b (delta392) of KIAA1045 (Phf24) was generated by Platinum TALEN methods. Although spontaneous GTCS is not observed, seizure susceptibility is increased and kindling induced by PTZ is promoted. In addition, locomotor activity is increased, disturbed behavior and spacial memory are decreased, and emotional behavior is increased due to unpleasant stimulation. National BioResource Project for the Rat in Japan 38676450 mutant Rat Genome Database (RGD) RGD Live Animals; Cryopreserved Sperm (as of 2021-07-01) 38676450 2026-09-05 06:52:42 0
WI-Prdm14em10Nips
 
Resource Report
Resource Website
RRID:RGD_41457452 Rattus norvegicus Prdm14 mutation was induced by introducing ribonucleic complexes (crRNA, tract RNA and Cas9 protein) into Crlj:WI rat embryos using electroporator. The resulting mutation is a 4412-bp deletion in exon 1 to 4. Homozygous Prdm14 knocked-out rats have the germ cell-deficient phenotype. Section of Mammalian Transgenesis, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki Aichi, JAPAN 41457452 mutant Rat Genome Database (RGD) RGD Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2021-02-24) 41457452 2026-09-05 06:52:42 0
SD-Lrp5em1Vari
 
Resource Report
Resource Website
RRID:RGD_41404646 Rattus norvegicus CRISPR/Cas9 system was used to introduce a 18-bp deletion of exon 2 in the rat Lrp5 gene of Crl:SD embryos. 41404646 mutant Rat Genome Database (RGD) RGD Unknown 41404646 2026-09-05 06:52:42 0
F344.LE-ROSA26 em1(LTR-nLuc)Ottc
 
Resource Report
Resource Website
RRID:RGD_38508893 Rattus norvegicus The mutated ROSA26 locus of LE-(ROSA)26 em1(LTR-nLuc)Ottc (RGD:13208223) was crossed onto Fischer344 background by backcrossing the hybrid to Fischer344 and select for the presence of mutated locus. The LE donor is CRISPR/Case9 knock-in strain that has cre recombinase-dependent expression of nanoluciferase under the control of HIV LTR promoter inserted to the rat ROSA26 locus. 38508893 mutant Rat Genome Database (RGD) RGD Unknown 38508893 2026-09-05 06:52:42 0
WIC-Sparcem1Kykn
 
Resource Report
Resource Website
RRID:RGD_39128166 Rattus norvegicus By CRISPR/Cas9 system, mutation was introduced in Sparc gene of Wistar-Imamichi rat. 7 bp deletion around Exon7. National BioResource Project for the Rat in Japan 39128166 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2020-09-23) 39128166 2026-09-05 06:52:42 0
WIC-Cspg4em2Kyst
 
Resource Report
Resource Website
RRID:RGD_39128162 Rattus norvegicus By CRISPR/Cas9 system, mutation was introduced in Cspg4 gene of Wistar-Imamichi rat. 7 bp deletion on Exon1. National BioResource Project for the Rat in Japan 39128162 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2020-09-23) 39128162 2026-09-05 06:52:42 0
F344-Il2rgem1IexasRag2em1Iexas
 
Resource Report
Resource Website
1+ mentions
RRID:RGD_38599190 Rattus norvegicus This strain was established by targeting Il2rg gene and Rag2 gene in F344/Jcl using CRISPR/Cas9 system. gRNA seq to Il2rg: CCAACCTCACTATGCACTATAGG (PAM: first CCA); gRNA to Rag2: AACATAGCCTTAATTCAACCAGG (PAM: last AGG); Cas 9 mRNA transcribed from T7-NLS hCas9-pA (RDB13130) was used for the system. Gene transfer was performed by electroporation.This strain shows severe combined immunodeficiency (SCID) caused by 5-bp deletion in Il2rg gene on X chromosome and 1-bp insertion in Rag2 gene on chromosome 3. This strain grows normally under SPF condition. The sexual maturation is a bit late. National BioResource Project for the Rat in Japan 38599190 mutant Rat Genome Database (RGD) RGD Cryopreserved Embryo (as of 2020-09-14) 38599190 2026-09-05 06:52:42 1
SD-Htr7em1Msu
 
Resource Report
Resource Website
RRID:RGD_14696715 Rattus norvegicus CRISPR/Cas9 system was used to generate this mutant; this induced an 11 bp deletion in exon 1 and a 4 bp deletion in exon 2 of the Htr7 gene. 14696715 mutant Rat Genome Database (RGD) RGD Unknown 14696715 2026-09-05 06:52:42 0
SS-Vwfem3Mcwi-/-
 
Resource Report
Resource Website
RRID:RGD_18182946 Rattus norvegicus CRISPR/Cas9 mediated gene editing was used to delete a 130,921bp region of the VWF gene in DahlSS/Mcw (SS/JrHsdMcwi ) rat embryos Contact MCW rat distribution at [email protected] 18182946 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2020-01-14) 18182946 2026-09-05 06:52:42 0
W-Gnrh1tm1(cre)Aeh
 
Resource Report
Resource Website
RRID:RGD_35668859 Rattus norvegicus This model was generated using zinc finger nuclease (ZFN) method. Cre recombinase was expressed under the control of the endogenous Gnrh1 gene by inserting an internal ribosomal entry site (IRES)-Cre cassette 30bp downstream from the translational stop site of the Gnrh1 open reading frame. This was achieved by pronuclear co-injection of zinc finger nucleases (ATCCACAACATCCGAGTGtgacattGACGCTGAGATCCATGAC; cleavage site in lower case) along with a donor plasmid containing two 800bp homologous arms (HA) flanking IRES-Cre into a one-cell stage rat embryo. (1.) Allan Herbison at Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; (2.) Vincent Prevot in INSERM, Lille, France. 35668859 mutant Rat Genome Database (RGD) RGD Live Animals (as of 2020-07-09) 35668859 2026-09-05 06:52:42 0
F344 -Aspaem34Kyo Hcn1em1Kyo
 
Resource Report
Resource Website
RRID:RGD_150429634 Rattus norvegicus F344-Aspaem34Kyo (RGD:11564349) and F344-Hcn1em1Kyo (RGD:38676253) rats from the National BioResource Project-Rat were intercrossed to produce F1 hybrids and then to obtain F2 progeny. Rats homozygous for both Aspa and Hcn1 knockout alleles were selected from among F2 progeny and were used to generate the F344-Aspaem34Kyo/Hcn1em1Kyo double- knockout strain. 150429634 mutant Rat Genome Database (RGD) RGD Unknown 150429634 2026-09-05 06:52:42 0
SD-Bace1em1Sage
 
Resource Report
Resource Website
RRID:RGD_14394485 Rattus norvegicus The mutant rats were generated by SAGE Labs using zinc-finger nuclease (ZFN) technology to create a 137-base pair deletion spanning the translation initiation start site in exon 1 of the rat Bace1 gene, corresponding to chr8:48,766,315-48,766,452 (RGSC 5.0/rn5 assembly) 14394485 mutant Rat Genome Database (RGD) RGD Unknown 14394485 2026-09-05 06:52:42 0
WIC-Wwoxlde/Fta
 
Resource Report
Resource Website
RRID:RGD_150429960 Rattus norvegicus Established from a closed colony of Wistar-Imamichi (WIC) rats as a spontaneous mutant exhibiting severe dwarfism, short lifespan (early postnatal lethality), and high incidence of epileptic seizures. Mutant rats showed growth retardation after 3 d of age, and at 21 d their weight was about 56% that of normal rats. Sequencing of the full-length Wwox transcript identified a 13-bp deletion in exon 9 in lde/lde rats. This mutation causes a frame shift, resulting in aberrant amino acid sequences at the C-terminal. 150429960 mutant Rat Genome Database (RGD) RGD Unknown 150429960 2026-09-05 06:52:42 0
LE-Arid1bem1Mcwi
 
Resource Report
Resource Website
1+ mentions
RRID:RGD_14394518 Rattus norvegicus CRISPR/Cas9 system was used to introduce a mutation in the Arid1b gene of Crl:LE rat embryos. The resulting mutation is deletion of exon 4. Autism Rat Model Resource, Contact MCW rat distribution at [email protected] 14394518 mutant Rat Genome Database (RGD) RGD Live Animals; Cryopreserved Sperm (as of 2025-02-20) 14394518 2026-09-05 06:52:42 1
SHR-Camk2n1em1Tja-/-
 
Resource Report
Resource Website
RRID:RGD_19259464 Rattus norvegicus SHR-Camk2n1-/- knockout rats were generated on an SHR/NCrl background by microinjecting zinc-finger nuclease (ZFN) mRNA (Sigma), targeted to exon 1 of Camk2n1, into one-cell stage SHR/NCrl embryos that were implanted into pseudopregnant rats. Heterozygous progeny, from a founder harboring a 38bp deletion in Camk2n1, were intercrossed to generate homozygous knockout rats. 19259464 mutant Rat Genome Database (RGD) RGD Unknown 19259464 2026-09-05 06:52:42 0
SD-Cftrem1Ang
 
Resource Report
Resource Website
RRID:RGD_126925992 Rattus norvegicus The CRISPR/Cas9 system targeting at exon 12 to create deletion at codon F508 was injected to the male pronucleus of the fertalized one-cell stage embryos collected from Crl:SD. The donor DNA generated a codon deletion at F508 and the creation of one NdeI restriction site for sequencing identification. 126925992 mutant Rat Genome Database (RGD) RGD Unknown 126925992 2026-09-05 06:52:42 0
SD-Cftrem2Ang
 
Resource Report
Resource Website
RRID:RGD_126925994 Rattus norvegicus The CRISPR/Cas9 system targeting at exon 3 to create gene knock out was injected to the male pronucleus of the fertalized one-cell stage embryos collected from Crl:SD. The donor DNA generated a frameshift and the creation of one XbaI restriction site and a premature stop codon. Two knockout founders ( referred as MUKORAT8.3 and MUKORAT 6.4) exhibit no difference in phenotypes and were pooled for study. 126925994 mutant Rat Genome Database (RGD) RGD Unknown 126925994 2026-09-05 06:52:42 0
SD-Defb23em2MlitDefb26em2MlitDefb42em1Mlit
 
Resource Report
Resource Website
RRID:RGD_38549357 Rattus norvegicus CRISPR/Cas9 system was used to generate the Defb23, Defb26 double-gene knockout (RGD:38549356) and Defb42 (RGD:38549355). The triple-KO rats were generated by crossing the heterozygous Defb23/26 mutation rats with the heterozygous Defb42 mutation rats. 38549357 mutant Rat Genome Database (RGD) RGD Unknown 38549357 2026-09-05 06:52:42 0
SD-Hamp em4Jfcol +/-
 
Resource Report
Resource Website
1+ mentions
RRID:RGD_36174225 Rattus norvegicus Hamp KO, Sprague-Dawley rats were generated by Transposagen Biopharmaceuticals (Lexington, KY). Four different genetically engineered rat lines, each with different sized Hamp deletions (with or without concurrent insertions), were created using TALEN technology. SD-Hamp em4Jfcol +/- (RGD:36174225) is heterozygous carrying a 15-bp deletion in exon 2 of the rat Hamp gene Rat Resource & Research Center (RRRC) 36174225 mutant Rat Genome Database (RGD) RGD Cryopreserved Sperm (as of 2020-07-29) 36174225 2026-09-05 06:52:42 1

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