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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13799350
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2018-10-10)
Alternate IDs: 13799350
Notes: CRISPR/Cas9 system was used to introduce a 2-bp deletion in exon 1 of F2r gene in the T2DN/Mcwi embryos. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13799350 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800871
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 13800871
Notes: CRISPR/Cas9 system was used to introduce a mutation in the P2ry2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 115-bp deletion in exon 3 in the P2ry2 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13800871 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800875
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 13800875
Notes: CRISPR/Cas9 and plasmid donor containing floxed human prolactin cDNA were used to insert the human cDNA into the start coden of rat prolactin gene Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13800875 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800877
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2026-01-14)
Alternate IDs: 13800877
Notes: CRISPR/Cas9 system was used to introduce a net 10-bp insertion in exon 2 of rat C17h6orf52.
Proper citation: RRID:RGD_13800877 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13793378
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2018-10-03)
Alternate IDs: 13793378
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Avpr2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 9-bp deletion in exon 2. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13793378 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13793374
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2018-10-03)
Alternate IDs: 13793374
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Tph1 gene of DA/MolTac rat embryos. The resulting mutation is a 1-bp deletion in exon 4. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13793374 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13799346
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2018-10-10)
Alternate IDs: 13799346
Notes: CRISPR/Cas9 system was used to introduce a 80-bp deletion on exon 2 of Cgnl1 gene in SS/JrHsdMcwi embryos Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13799346 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13207492
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals (as of 2017-08-02)
Alternate IDs: 13207492
Notes: CRISPR/Cas9 system was used to introduce a 4-bp deletion of exon 2 in the rat Cd55 gene of Crl:SD embryos. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13207492 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13464263
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Live Animals; Cryopreserved Sperm (as of 2018-01-02)
Alternate IDs: 13464263
Notes: This strain was established by CRISPR/Cas9 targeting rat Il2rg gene using electroporation. background strain: F344/Jcl. This strain shows severe combined immunodeficiency (SCID) caused by 5-bp deletion of Il2rg gene. This strain grows normally under SPF condition. National BioResource Project for the Rat in Japan
Proper citation: RRID:RGD_13464263 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13207497
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2021-11-03)
Alternate IDs: 13207497
Notes: CRISPR/Cas9 system was used to introduce a mutation in the Kcnj13 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 1-bp insertion of exon 2 in the Kcnj13 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13207497 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13800869
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 13800869
Notes: CRISPR/Cas9 system was used to introduce a mutation in the P2ry2 gene of SS/JrHsdMcwi rat embryos. The resulting mutation is a 132-bp deletion in exon 3 in the P2ry2 gene. Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13800869 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792795
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 13792795
Notes: A pair of TALENs targeting exon 1 of the Fh gene was injected into SD embryos to create Fh knock out mutants. The resulting mutation was an 11-bp deletion (acacctttggt) on exon 1 that caused premature stop of FH protein. Breeding of Fh +/- rats was done to generate wildtype (Fh+/+)and Fh (+/-). No homozygous mutant were observed.
Proper citation: RRID:RGD_13792795 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13799348
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2018-10-10)
Alternate IDs: 13799348
Notes: CRISPR/Cas9 system was used to introduce a 88-bp deletion on exon 2 of Cgnl1 gene in SS/JrHsdMcwi embryos Contact MCW rat distribution at [email protected]
Proper citation: RRID:RGD_13799348 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792794
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 13792794
Notes: A pair of TALENs targeting exon 1 of the Fh gene was injected into SD embryos to create Fh knock out mutants. The resulting mutation was an 11-bp deletion (acacctttggt) on exon 1 that caused premature stop of FH protein. No homozygous -/- mutant was revealed in litters.
Proper citation: RRID:RGD_13792794 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=14390069
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 14390069
Notes: The Slc6a4 knockout rat was generated by target-selected ENU-induced mutagenesis. An ENU-induced premature stop codon in exon 3 of the Slc6a4 gene in a female rat (Wistar from Crl) was identified.The heterozygoous mutant rats were used to generate homozygous Slc6a4 knock out rats.
Proper citation: RRID:RGD_14390069 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=127345097
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 127345097
Notes: The Muc1 knock out Sprague Dawley rats were produced by targeted gene mutation at rat Muc1 gene. The deletion was made by microinjection of TALENs and located in the exon 1 of rat Muc1 gene (Gen Bank: NM_012602.1). Genotyping was performed by PCR of tail DNA using primers specific for the rat MUC1 gene with forward primer 5′-CTAGCAAGCCTAAAAGGTGAGAGGT-3′ and reverse primer 5′-ACGAAGAGCATTTGCCTACTC-3′, followed by DNA sequencing analysis. Cyagen Biosciences Inc., Guangzhou, China
Proper citation: RRID:RGD_127345097 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150519901
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 150519901
Notes: CRISPR/Cas9 system containing guide RNAs targeting exon 2 and intron 2 were introduced into the F344/Stm embryos using a super electroporator NEPA 2. This mutant strain F344-Prkar1bem2Tua carried a 13-bp frameshift deletion in exon2 creating a premature stop codon in the Prkar1b transcripts. Expression levels of Prkar1b transcripts and protein are significantly decreased in the mutants.
Proper citation: RRID:RGD_150519901 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=36174030
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Cryopreserved Sperm (as of 2020-07-28)
Alternate IDs: 36174030
Notes: Hamp KO, Sprague-Dawley rats were generated by Transposagen Biopharmaceuticals (Lexington, KY). Four different genetically engineered rat lines, each with different sized Hamp deletions (with or without concurrent insertions), were created using TALEN technology. SD-Hamp em1Jfcol +/- (RGD: 36174030) is heterozygous carrying a 169-bp deletion between exons 2 & 3 of rat Hamp gene. Rat Resource & Research Center (RRRC)
Proper citation: RRID:RGD_36174030 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150429825
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 150429825
Notes: Exon 25 of the rat Scn9a gene was replaced with the human SCN9A exon counterpart (exon 26) using ZFN technology. The mRNAs of the active ZFN pair targets middle region of the exon (CACCATCATGGTTCTTATAtgcctcAACATGGTAA CCATGATG, ZFN binding sites in uppercase). Charles River Laboratories
Proper citation: RRID:RGD_150429825 Copy
https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=13792570
Source Database: Rat Genome Database (RGD)
Genetic Background: mutant
Availability: Unknown
Alternate IDs: 13792570
Notes: The original mutants were created by target-selected ENU-induced mutagenesis in a Brown Norway background. The animals were outcrossed for two generations on a Brown Norway background. they were subsequently backcrossed on a Wistar (Crl:WI) background for four generations. Backcrossings were performed to eliminate possible additional mutations induced by ENU-mutagenesis. Heterozygous oprl1+/- rats were crossed to generate the experimental animals. A C to G transversion at position 3657 in the oprl1 gene (ENSRNOG00000016768), resulting into a premature stop codon (TAC>TAG) in the third exon.
Proper citation: RRID:RGD_13792570 Copy
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