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http://griffin.cbrc.jp/

Griffin (G-protein-receptor interacting feature finding instrument) is a high-throughput system to predict GPCR - G-protein coupling selectively with the input of GPCR sequence and ligand molecular weight. This system consists of two parts: 1) HMM section using family specific multiple alignment of GPCRs, 2) SVM section using physico-chemical feature vectors in GPCR sequence. G-protein coupled receptors (GPCR), which is composed of seven transmembrane helices, play a role as interface of signal transduction. The external stimulation for GPCR, induce the coupling with G-protein (Gi/o, Gq/11, Gs, G12/13) followed by different kinds of signal transduction to inner cell. About half of distributed drugs are intending to control this GPCR - G-protein binding system, and therefore this system is important research target for the development of effective drug. For this purpose, it is necessary to monitor, effectively and comprehensively, of the activation of G-protein by identifying ligand combined with GPCR. Since, at present, it is difficult to construct such biochemical experiment system, if the answers for experimental results can be prepared beforehand by using bioinformatics techniques, large progress is brought to G-protein related drug design. Previous works for predicting GPCR-G protein coupling selectivity are using sequence pattern search, statistical models, and HMM representations showed high sensitivity of predictions. However, there are still no works that can predict with both high sensitivity and specificity. In this work we extracted comprehensively the physico-chemical parameters of each part of ligand, GPCR and G-protein, and choose the parameters which have strong correlation with the coupling selectivity of G-protein. These parameters were put as a feature vector, used for GPCR classification based on SVM.

Proper citation: G protein receptor interaction feature finding instrument (RRID:SCR_008343) Copy   

•   Source: SciCrunch Registry

https://www.selectscience.net/suppliers/sirius-analytical/?compID=5860

Organization that designs and manufactures analytical instrumentation to measure physicochemical parameters for the pharmaceutical and biotech industry, as well as offers physicochemical data and consultancy services. Their instruments provide accurate and reliable values for pKa, log P, log D, solubility and dissolution, particle size and shape analysis. These critical physicochemical parameters are important in drug formulation, and also influence the ability of New Chemical Entities to cross biological membranes such as the gastro-intestinal tract, blood-brain barrier, skin and cell walls. Sirius also offers an analytical service for high quality PhysChem outsourcing, used by hundreds of clients worldwide.

Proper citation: Sirius Analytical (RRID:SCR_003945) Copy   

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http://www.iitcinc.com/Plantar.html

The IITC Plantar Analgesia Meter for thermal paw can be used on 12 mice, 6 rats and other animals (cats, rabbits) unrestrained when testing for narcotic drugs. Experiments are easy to perform, simply slide the test head under test subject, align the heat source via our exclusive guide light (idle state) by the attached, adjustable, angled mirror on test head to test subject and perform tests.

Proper citation: IITC Life Sciences: Plantar Test Apparatus (RRID:SCR_012152) Copy   

•   Source: SciCrunch Registry

https://drive.google.com/file/d/1a0Hs2SPvnvrkIi3QalcgaLNkG-VmqFmv/view?usp=drivesdk

Temperature datalogger compatible with 7 types of thermocouples. This dual input thermometer accepts Types J, K, E, T, R, S, and N thermocouples. RS-232 port to transfer data to PC for analysis (PC software and cable included)

Proper citation: Extech: EA15: EasyView Dual Input Temperature Datalogger (RRID:SCR_012151) Copy   

•   Source: SciCrunch Registry

https://github.com/rsc-ontologies/rsc-cmo

An ontology that describes methods used to collect data in chemical experiments, such as mass spectrometry and electron microscopy; preparing and separating material for further analysis, such as sample ionization, chromatography, and electrophoresis; and synthesizing materials, such as epitaxy and continuous vapor deposition. It also describes the instruments used in these experiments, such as mass spectrometers and chromatography columns. It is intended to be complementary to the Ontology for Biomedical Investigations (OBI).

Proper citation: Chemical Methods Ontology (RRID:SCR_003286) Copy   

•   Source: SciCrunch Registry

http://www.pstnet.com/hardware.cfm?ID=91

Instrument that accurately gathers participant responses and verifies signals. The Celeritas Series response units are assembled using high-impact, chemical resistant, medical grade plastic. The response units include a tactile indicator to ensure correct finger placement during experiments and comfortably attach to the participant?s wrists. The units communicate button presses through fiber optic cabling which connects to a Fiber Optic Interface Console located in the control room through an available wave guide. The interface console provides real-time feedback of participant responses via LED indicators and includes a set of switches which can be used to make responses for the participant as needed.

Proper citation: Fiber Optic Button Response System (RRID:SCR_009577) Copy   

•   Source: SciCrunch Registry

https://www.nitrc.org/projects/lumina/

A reliable patient response system designed specifically for use in an fMRI. Lumina was developed to satisfy the requirements of both the clinical and research fields.

Proper citation: Lumina LP- 400 Response System (RRID:SCR_009596) Copy   

•   Source: SciCrunch Registry

http://www.rogue-research.com

Neuronavigation system for use in human cognitive neuroscience (TMS, EEG, NIRS) and for non-human neurosurgical applications.

Proper citation: Brainsight (RRID:SCR_009539) Copy   

•   Source: SciCrunch Registry

https://drive.google.com/file/d/1hBdRU27fsVkioRZb_IY_8BGPwIi_2ipq/view?usp=drivesdk

Automated, high throughput microscale bioreactor system that replicates laboratory scale bioreactor performance., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: Thermo Fisher: Sartorius: Ambr 15 Cell Culture Generation 2 (RRID:SCR_013797) Copy   

•   Source: SciCrunch Registry

http://www.osmicenterprises.com

A computerized, odor delivery device that can be used for basic research applications including mapping olfactory centers, cognitive / learning research, neuro-marketing among other uses. Additional products including tests for odor threshold, odor identification, odor discrimination and odor memory.

Proper citation: OEI: fMRI compatible olfactometer (RRID:SCR_002507) Copy   

•   Source: SciCrunch Registry

https://i4sa.com/wp-content/uploads/2021/01/1025ManualRevJ.pdf

Magnetic resonance compatible monitoring and gating system, including software, that enables monitoring rectal temperature, electrocardiogram and respiration rate during magnetic resonance imaging scan time. The PC displays multiple waveforms, measured values, trends and gating pulses. The data Acquisition modules are controlled by menu driven software from the PC. Data acquisition modules are available to measure the following parameters: ECG, respiration (three ways), temperature (two ways), pressure including invasive blood pressure (two ways), oxygen saturation and end-tidal CO2.

Proper citation: SA Instruments: Model 1025 MR-compatible Small Animal Monitoring and Gating System (RRID:SCR_002090) Copy   

•   Source: SciCrunch Registry

https://www.leica-microsystems.com/products/confocal-microscopes/p/leica-tcs-spe/

High resolution, compact and robust confocal that enables immunohistochemical colocalization analysis of florescent markers. Leica TCS SPE confocal point-scanning, spectral system for fluorescence imaging of live or fixed cells.

Proper citation: Leica: TCS SPE (RRID:SCR_002140) Copy   

•   Source: SciCrunch Registry

https://www.bd.com/resource.aspx?IDX=17868

Benchtop high-performance cell sorter with multiple lazer, detector and fluoroscrome options. Allows detection of 12 parameters (10 color conjugates, forward and sideward scatter).

Proper citation: BD Biosciences: LSR II Flow Cytometer (RRID:SCR_002159) Copy   

•   Source: SciCrunch Registry

http://neuronetrix.com/

A portable, highly integrated, internet-enabled, hardware / software platform and patient management system, which includes an online Patient Manager module which complies with the HIPAA Final Security Rule, an event-related potential (ERP) Viewer module to view and analyze raw and average ERP waves, and a Protocol Editor module to simplify the choice and administration of selected ERP protocols. It is also easy to train and administer with non-specialized personnel, and is designed to be used in an out-patient setting. COGNISION TM with auditory or visual event-related potential (ERP) technology, provides a direct physiologic measure of patients' cognitive processing (i.e., a cognitive biomarker).

Proper citation: COGNISION (RRID:SCR_002362) Copy   

•   Source: SciCrunch Registry

http://www.uu.nl/faculty/veterinarymedicine/EN/labs_services/CCI/Documents/Instructie%20Leica%20DMRE%20fluorescentie%20microscoop.pdf

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. Microscope that enables bright field and fluorescence imaging options.

Proper citation: Leica: DMRE Fluorescence Microscope (RRID:SCR_000011) Copy   

•   Source: SciCrunch Registry

https://www.bdbiosciences.com/en-us/products/instruments/flow-cytometers/research-cell-sorters/bd-facsaria-iii

Instrument for cell sorting by BD Biosciences where positive air pressure forces sample cell through an optically gel-coupled cuvette . Hydrodynamic focusing guides particles in a single-file stream through the cuvette, where laser light intercepts the stream at the sample interrogation point.Fluorescence activated cell sorting instrument. Flow cytometer as high speed fixed alignment benchtop cell sorter. Enables multicolor analysis of up to 13 fluorescent markers and two scatter parameters at time.

Proper citation: BD Biosciences: FACSAria III Cell Sorter (RRID:SCR_016695) Copy   

•   Source: SciCrunch Registry

https://www.leicabiosystems.com/us/histology-equipment/cryostats/leica-cm3050-s/

Instrument designed for cryosectioning in biomedical, neuro-anatomical and pharmaceutical research.

Proper citation: Leica: CM3050 S Research Cryostat (RRID:SCR_016844) Copy   

•   Source: SciCrunch Registry

https://bionanogenomics.com/wp-content/uploads/2017/01/30047-Irys-User-Guide.pdf

System by BioNano Genomics ( formerly BioNanomatrix) which provides optical next generation mapping (NGM). Used for sequence assembly and structural variation analysis. Provides Scaffold Bionano genome mapping data with sequencing data to improve assembly contiguity, reduce sequencing coverage needed, and automatically correct errors in sequencing based assemblies.

Proper citation: BioNano: Irys system (RRID:SCR_016754) Copy   

•   Source: SciCrunch Registry

https://link.springer.com/article/10.1007%2Fs00424-017-2067-y

Integrated circuit device used as tool for amperometry measurement as replacement of conventional carbon fiber microelectrode. Surface modified structures with SU 8 microwells increases life span of each individual device and achieves single cell measurement efficiency by trapping cells inside microwells.

Proper citation: Surface Modified Amperometry CMOS IC (RRID:SCR_017082) Copy   

•   Source: SciCrunch Registry

https://www.olympus-global.com/news/2016/nr160405fv3000e.html

FV3000 is a laser scanning confocal microscope system that captures high-resolution, high-contrast images by scanning samples point by point, enabling precise 3D fluorescence imaging. The system supports inverted and upright configurations and accommodates various objectives with magnifications ranging from 1.25× to 100×, including oil, silicone, and dry lenses, which allows imaging of both macro and micro-scale samples. It is equipped with multiple laser lines for excitation, including 405 nm, 488 nm, 561 nm, and 640 nm, as well as additional lines in some configurations (445 nm, 514 nm, 594 nm, 630 nm), enabling the use of several fluorophores simultaneously. On the detection side, the microscope uses high-sensitivity photomultiplier tube detectors, including GaAsP PMTs and multi-alkali PMTs.

Proper citation: Olympus: FluoView FV3000 Confocal Laser Scanning Microscope (RRID:SCR_017015) Copy   

•   Source: SciCrunch Registry