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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
System for long term volumetric imaging of living cells. Makes light sheet fluorescence microscopy available for live cell imaging at subcellular resolution. Automated system for volumetric imaging of subcellular structures and dynamics over hours and days with protection from photo damage.
Proper citation: Zeiss: Lattice Lightsheet 7 (RRID:SCR_021237) Copy
https://diagnostics.roche.com/us/en/products/instruments/discovery-ultra-research.html
Immunohistochemistry processor that can be used for immunohistochemistry and in situ hybridization slide preparation and processing. With 30 individual slide drawers, DISCOVERY ULTRA system enables to run both manual and fully automated experiments simultaneously with nosynchronization errors. Provides ability to fully automate broad range of IHC and ISH assays, including FISH, gene and protein IHC/ISH, mRNA ISH and multiplex assays with any combination of IHC and ISH.
Proper citation: Roche: Ventana DISCOVERY Ultra (RRID:SCR_021254) Copy
https://www.kentscientific.com/products/somnoflo/
Compact, standalone vaporizer that uses either ambient air with internal air pump or compressed gas. It delivers only anesthetic required by animal according to its weight with flows down to 0.05 LPM. Low flow isoflurane anesthesia machine.
Proper citation: Kent Scientific: SomnoFlow Low Flow Electronic Vaporizer (RRID:SCR_021629) Copy
https://www.nanostring.com/products/geomx-digital-spatial-profiler/geomx-dsp-overview/
Integrated commercial system comprising hardware, software and nCounter chemistry that enables simultaneous, highly multiplex spatial profiling of proteins or RNA in FFPE tissues. DSP platform quantifies abundance of protein or RNA by counting unique indexing oligonucleotides assigned to each target of interest. Used to rapidly and quantitatively assess biological implications of heterogeneity within tissue samples.
Proper citation: NanoString: GeoMx Digital Spatial Profiler (RRID:SCR_021660) Copy
https://meyerinst.com/library/NanoZoomer_RS_Brochure_Catalog.pdf
High speed, high resolution digital scanner with network features. User friendly full slide scanner designed to process up to 210 slides automatically.
Proper citation: Hamamatsu: NanoZoomer 2.0-HT (RRID:SCR_021658) Copy
System includes automated cell counter for trypan blue viability for cell lines and bright field imaging and pattern recognition software to quickly and accurately identify and count individual cells. Cell count, concentration, diameter, and % viability are automatically calculated and reported.
Proper citation: McKinley: Cellometer Auto T4 (RRID:SCR_021656) Copy
http://tools.thermofisher.com/content/sfs/manuals/nd-1000-v3.8-users-manual-8%205x11.pdf
Spectrophotometer for measurement and analysis of 1 ul samples with high accuracy and reproducibility. Full spectrum from 220nm to 750nm spectrophotometer utilizes patented sample retention technology that employs surface tension alone to hold sample in place. No need for cuvettes. Has capability to measure highly concentrated samples without dilution.
Proper citation: Thermo Fisher: Nanodrop 1000 Spectrophotometer (RRID:SCR_016517) Copy
Instrument for cell sorting by BD Biosciences where positive air pressure forces sample cell through an optically gel-coupled cuvette . Hydrodynamic focusing guides particles in a single-file stream through the cuvette, where laser light intercepts the stream at the sample interrogation point.Fluorescence activated cell sorting instrument. Flow cytometer as high speed fixed alignment benchtop cell sorter. Enables multicolor analysis of up to 13 fluorescent markers and two scatter parameters at time.
Proper citation: BD Biosciences: FACSAria III Cell Sorter (RRID:SCR_016695) Copy
https://sites.google.com/view/epsilon-uarizona/home?authuser=0
Facility offers imaging spectroscopy. Equipped with Xray Photoemission Spectroscopy, Ultraviolet Photoemission Spectroscopy, Inverse Photoemission Spectroscopy, energy filtered Photoelectron Emission Microscopy, and spatially resolved Angle Resolved Photoemission Spectroscopy and spatially resolved Xray Photoemission Spectroscopy.
Proper citation: University of Arizona Electron Photoemission Spectroscopy and Imaging Laboratory for Observation at the Nanoscale Core Facility (RRID:SCR_022887) Copy
https://cbc.arizona.edu/research/support-services/facilities/x-ray-diffraction-facility
Facility for investigation of single crystal and powder/thin film samples by X-Ray diffraction techniques.
Proper citation: University of Arizona Xray Diffraction Core Facility (RRID:SCR_022886) Copy
https://www.vet.upenn.edu/research/core-resources-facilities/imaging-core
Core provides access to light microscope systems to perform widefield, confocal, 2-photon/multiphoton, second harmonic generation, total internal reflection (TIRF), and high content imaging.
Proper citation: University of Pennsylvania Penn Vet Imaging Core Facility (RRID:SCR_022764) Copy
Core for surface science, thin films studies, and nano scale characterization. Provides analytical and educational services to department and university on preparation, modification, and study of solid surfaces.
Proper citation: University of Arizona Laboratory for Electron Spectroscopy and Surface Analysis Core Facility (RRID:SCR_022885) Copy
Offers access to instrumentation, training, and service using advanced light microscopy, scanning electron microscopy, and transmission electron microscopy. Provides access to core imaging and analytical characterization technologies. In addition to instrument access, SRNML personnel offer advice, hands-on training, education, and research collaboration. Provides range of sample preparation equipment.
Proper citation: University of Oklahoma Samuel Roberts Nobel Microscopy Laboratory Core Facility (RRID:SCR_022929) Copy
https://voices.uchicago.edu/proteomics/
Core to develop and utilize proteomics techniques to answer both basic and translational scientific questions.
Proper citation: University of Chicago Proteomics Platform Core Facility (RRID:SCR_022928) Copy
https://www.mcw.edu/departments/genomic-sciences-and-precision-medicine-center-gspmc
Core for advancing genomic sciences and precision medicine in fields of Omics, Data Science, and Systems Biology. Provides whole genome sequencing technologies to investigate how gene variants impact gene expression and to define genetic variants associated with rare and common disease, embryonic development, and effects of environmental factors and drugs upon gene expression and disease.
Proper citation: Medical College of Wisconsin Mellowes Center for Genomic Sciences and Precision Medicine Core Facility (RRID:SCR_022926) Copy
Nanomaterials and nanostructures grown in INML are used in lasers, solar cells, detectors, transistors, modulators, and a wide range of other electronic and photonic devices.
Proper citation: University of California at Los Angeles California NanoSystems Institute Integrated NanoMaterials Laboratory Core Facility (RRID:SCR_022925) Copy
https://voices.uchicago.edu/animalcareprogram/graf/
One of the largest academic gnotobiotic mouse facilities internationally.Centrally managed gnotobiotic/germ free mouse facility located within centrally managed Knapp Center for Biomedical Discovery vivarium.GRAF currently maintains over 80 flexible film isolators with capacity for greater than 1045 mouse cages.
Proper citation: University of Chicago Gnotobiotic Research Animal Core Facility (RRID:SCR_022934) Copy
https://voices.uchicago.edu/bnmr/
Facility houses Bruker AVANCE IIIHD 600 and Bruker AVANCE III 500 NMR spectrometer. These are equipped with high sensitivity inverse and broadband probes, single axis gradients, pulse shaping capabilities, variable temperature control(-50C to 150C), and automatic tuning and matching.Bruker AVANCE IIIHD 600 is also equipped with robotic sample changer (Bruker SamplExpress) allowing automated acquisition of up to 60 samples. Sample preparation can also be automated with Gilson sample preparation robot.
Proper citation: University of Chicago Biomolecular Nuclear Magnetic Resonance Core Facility (RRID:SCR_022933) Copy
https://www.med.upenn.edu/bbl/bbl-cnb.html
Core aims to facilitate research in cognitive neuroscience through use of Computerized Neurocognitive Battery and neuroimaging.CNB is comprised of series of tests that have been applied in neuroimaging studies and can be used either in scanner as part of functional neuroimaging study or outside scanner for measuring individual differences in performance. Tests measure accuracy and speed of performance in major domains of cognition, including executive control functions (abstraction, attention, working memory), episodic memory (verbal, facial, spatial), complex cognitive processing (language reasoning, nonverbal reasoning, spatial processing), social cognition (emotion identification, emotion intensity differentiation, age differentiation) and sensorimotor and motor speed.
Proper citation: University of Pennsylvania Perelman School of Medicine Neuroimaging and Cognitive Core Facility (RRID:SCR_022899) Copy
https://voices.uchicago.edu/metabolomics/
Equipped with Thermo Scientific Orbitrap IQ-X Tribrid mass spectrometer(+UVPD)- Vanquish Horizon UHPLC system. Provides experience in quantifying diverse groups of metabolites in cells, culture medium, bodily fluid, animal tissue, exhaled breath condensate, etc., and performes stable isotope tracing experiments using 13C, 15N, and 2H-labeled substrates. Support hypothesis generating untargeted and hypothesis driven targeted metabolomics studies from experimental design stage through data acquisition, data analysis, and interpretation.
Proper citation: University of Chicago Metabolomics Platform Core Facility (RRID:SCR_022932) Copy
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