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https://sbpdiscovery.org/research/shared-resources/flow-cytometry/

Facility that provides access to high-speed cell sorting, analytical flow cytometry, imaging flow cytometry, and validated immune profiling spectral antibody panels. Core staff provide technical expertise in experiment design, data analysis, hardware and software training, operate the facility cell sorters, and are available to assist with analysis experiments for those who prefer to have their samples run by an expert cytometrist.

Proper citation: Sanford Burnham Prebys Medical Discovery Institute Flow Cytometry Core Facility (RRID:SCR_014854) Copy   

•   Source: SciCrunch Registry

http://www.sbpdiscovery.org/technology/sr/Pages/LaJolla_CellularImaging.aspx

Medical research facility that supports research programs by providing access to sophisticated microscopes for digital imaging, as well as training, assistance and guidance. The core facility offers expertise, training and assistance in advanced biological microscopic imaging techniques and use of complex image processing software, use of well-maintained, aligned, and calibrated microscopic equipment, and troubleshooting of equipment and experimental problems.

Proper citation: Sanford Burnham Prebys Medical Discovery Institute Cellular Imaging Facillity (RRID:SCR_014855) Copy   

•   Source: SciCrunch Registry

http://www.sbpdiscovery.org/technology/sr/Pages/LaJolla_GenomicsMicroarrayQPCR.aspx

Facility that provides full-service microarray-based global analysis of gene expression in RNA samples from humans or mice using an Illumina platform. Services include RNA sample quality and quantity analysis, microarray analysis, and Q-PCR service and analysis, as well as special services such as RNA purification and Copy Number Variation analysis.

Proper citation: Sanford Burnham Prebys Medical Discovery Institute Genomics Microarray/Q-PCR Facility (RRID:SCR_014863) Copy   

•   Source: SciCrunch Registry

http://www.sbpdiscovery.org/technology/sr/Pages/LaJolla_ViralVectors.aspx

Facility that provides cost-effective production of high-quality, high-titer lentiviral, retroviral and adenoviral vectors. Services include production of ready-to-transduce lentiviral and adenoviral particles, custom lentiviral, retroviral, and adenoviral production and titrations. Other activities of the facility include packaging, concentrating, and titration of user-supplied lentiviral constructs. Specialized services include custom lentiviral vector construction for constitutive or inducible cDNA/shRNA expression as well as promoter/enhancer reporter, viral packaging, and titration (ready-to-transduce control particles provided).

Proper citation: Sanford Burnham Prebys Medical Discovery Institute Viral Vector Core Facility (RRID:SCR_014864) Copy   

•   Source: SciCrunch Registry

http://www.sbpdiscovery.org/technology/sr/Pages/LaJolla_NMR.aspx

Facility that acts as a centralized shared resource for NMR studies on proteins, peptides, small molecules, and carbohydrates in solution or in solid state. It provides instrumentation and expertise for NMR data collection. It also provides consultation with investigators on the feasibility of NMR for structural studies of protein candidates, as well as the optimal method to obtain solution structures and binding information by multi-dimensional NMR techniques. It can also train users in basic spectrometer operations, trouble-shoot for instrumental and operational problems, and set up NMR experiments for users as requested.

Proper citation: Sanford Burnham Prebys Medical Discovery Institute NMR Facility (RRID:SCR_014861) Copy   

•   Source: SciCrunch Registry

https://www.bcm.edu

Health sciences university located in Texas Medical Center in Houston, Texas, US. It includes medical school, Baylor College of Medicine, graduate school of Biomedical Sciences, School of Allied Health Sciences, and National School of Tropical Medicine.

Proper citation: Baylor College of Medicine; Houston; Texas (RRID:SCR_015037) Copy   

•   Source: SciCrunch Registry

http://www.sbpdiscovery.org/technology/sr/Pages/LaJolla_ProteinAnalysis.aspx

Facility that provides a variety of analytical services focused on biophysical characterization of structural and functional properties of proteins in solution, under native, non-denaturing conditions. Examples of services include quality control of protein samples (folding, stability, aggregation); measuring molecular weight of proteins, protein complexes, oligomers and assemblies; charcaterizing protein conformation and shape in solution; determining oligomeric state of protein (including stoichiometry and Kd for self-association) and measuring protein binding to proteins, peptides, small molecules, compounds, metals, nucleotides and other ligands (including determination of equilibrium (Kd) and kinetic rate (kon, koff) constants, stoichiometry, binding enthalpy and entropy).

Proper citation: Sanford Burnham Prebys Medical Discovery Institute Protein Analysis Core (RRID:SCR_014862) Copy   

•   Source: SciCrunch Registry

https://diabetes.med.umich.edu/affiliated-centers/michigan-diabetes-research-center-mdrc/cores/molecular-genetics

Core that provides services related to the application of genetic methodologies to research related to diabetes. Services include generation of targeted genetic mouse models, using CRISPR/Cas9 system in mouse or rat embryos, generation of specialty viral vectors, specialty viral reagents, and specialty mouse models.

Proper citation: Michigan Diabetes Research Center Molecular Genetics Core Facility (RRID:SCR_015119) Copy   

•   Source: SciCrunch Registry

http://depts.washington.edu/diabetes/administrative-core/

Core facility that supports the Diabetes Research Center in its primary mission to enhance research, education and training in diabetes, obesity and related disorders at the University of Washington and in the Greater Seattle area. The Core coordinates and manages programs, evaluates Center activities, and performs other duties.

Proper citation: University of Washington Diabetes Research Center Administrative Core (RRID:SCR_015124) Copy   

•   Source: SciCrunch Registry

http://www.med.upenn.edu/idom/drc/cores/fgc.html

Core which offers experiment planning, sample preparation, quality assessment, library construction, DNA sequencing, and data analysis services to DRC members. Its services also include RNAseq, microRNAseq, GroSeq, CLIP-seq, nucleosome mapping, ATAC-Seq, ChIPseq, Exome sequencing, whole genome and targeted methylome analysis, hydroxymethyl DIP, and single cell RNAseq.

Proper citation: Penn Diabetes Research Center Functional Genomics Core (RRID:SCR_015121) Copy   

•   Source: SciCrunch Registry

http://cdmd.indiana.edu/research-core/the-swine-core/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 14,2024. Core which utilizes a breeding colony of Ossabaw swine with metabolic syndrome and long-term complications, most notably cardiovascular disease. It provides swine maintenance (glucose tolerance tests, body composition, glucose clamp studies, and imaging studies), characterization of cardiovascular disease (intravascular ultrasound, blood flow velocity, microvascular studies), and tissues (both banked and fresh) for analysis ex vivo.

Proper citation: Indiana Diabetes Research Center Swine Core (RRID:SCR_015089) Copy   

•   Source: SciCrunch Registry

http://depts.washington.edu/diabetes/cellular-and-molecular-imaging/

Core facility that provides Diabetes Research Center affiliates with access to specialized expertise and equipment required for high quality histochemical and morphological analyses in a cost-effective manner.

Proper citation: University of Washington Diabetes Research Center Cellular and Molecular Imaging Core (RRID:SCR_015125) Copy   

•   Source: SciCrunch Registry

https://www.derc.cuimc.columbia.edu/services/mouse-metabolic-function-and-phenotyping-core

Core that provides services that facilitate the efficient characterization of mouse models of diabetes and its complications: NMR Body Composition Analysis, Whole Body Metabolic Assessment (chamber calorimetry with motion detection), Metabolic Clamps, Gastric Infusion/Feeding and Thermogenic Phenotyping.

Proper citation: Columbia Diabetes Research Center Mouse Metabolic Function and Phenotyping Core Facility (RRID:SCR_015082) Copy   

•   Source: SciCrunch Registry

https://diabetescenters.org/cores/indiana-microscopy-core

Core that provides consultation and specialized services for intravital microscopy of pancreas and transplanted islets, FRET assays, and fluorescent biosensors for analysis of intracellular signaling cascades to serve the area diabetes investigators.

Proper citation: Indiana Diabetes Research Center Microscopy Core Facility (RRID:SCR_015083) Copy   

•   Source: SciCrunch Registry

https://medicine.iu.edu/research-centers/diabetes/cores/islet-physiology

Services include islet isolation services from mice and rats and access to porcine and human islets. The core is equipped with BioRep Perifusion Apparatus for measurement of insulin secretion and offers services for islet and beta cell calcium imaging. Provides services for islet transplantation and assists investigators who wish to perform immunohistochemistry, immunofluorescence and/or analysis of endocrine or beta cell mass on whole pancreata from mouse and rat models.Offers services for rodent metabolic characterization, including performance of insulin and glucose tolerance testing, analysis of body composition, and metabolic cage analysis using the TSE System cages. Recently added services include zebrafish characterization to screen genes and small molecules for their effects on islet development and function.

Proper citation: Indiana University School of Medicine Center for Diabetes and Metabolic Diseases Islet and Physiology Core Facility (RRID:SCR_015081) Copy   

•   Source: SciCrunch Registry

https://joslinresearch.org/drc-cores/Induced-Pluripotent-Stem-Cell-Core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on November 6,2024. Core that maintains a centralized facility for the generation and propagation of reprogrammed iPS cells for use in molecular and cellular pathologies underlying diabetes and its complications.

Proper citation: Joslin Diabetes Center Induced Pluripotent Stem Cell Core (RRID:SCR_015120) Copy   

•   Source: SciCrunch Registry

https://diabetescenters.org/cores/indiana-translation-core

Core within Indiana Center for Diabetes and Metabolic Diseases that offers services that facilitate conduct of research involving human subjects, including providing low-cost, high quality analyte measurements for variety of hormones, cytokines, lipids and other analytes. Its human studies services include metabolic phenotyping (e.g. GTT, clamp studies, tracer studies), and access to a biobank of human tissues and serum.

Proper citation: Indiana Diabetes Research Center Translation Core Facility (RRID:SCR_015084) Copy   

•   Source: SciCrunch Registry

https://www.derc.cuimc.columbia.edu/services/advanced-tissue-pathology-and-imaging-core

Core that provides spectrum of advanced cellular and tissue pathology and imaging services for diabetes researchers at Columbia University. It also has microscopy equipment and services such as confocal, live 2-photon and scanning and transmission electron microscopy.

Proper citation: Columbia Diabetes Research Center Advanced Tissue Pathology and Imaging Core Facility (RRID:SCR_015085) Copy   

•   Source: SciCrunch Registry

http://www.hopkinsmedicine.org/diabetes-research-center/research-cores/cell-biology.html

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 9,2024. Core that provides services in tissue analysis and imaging, islet biology, liver biology, and adipocyte biology. It includes the indepedent cores Derivation of IPSC and Bioenergetics as well as the Specialty Animal Surgery Subcore and Bone Biology Subcore.

Proper citation: Johns Hopkins University - University of Maryland Diabetes Research Center Cell Biology Core (RRID:SCR_015090) Copy   

•   Source: SciCrunch Registry

http://www.lji.org/faculty-research/scientific-cores/dlac/#overview

The department of laboratory animal care at the La Jolla Institute for Allergy and Immunology.

Proper citation: La Jolla Institute for Allergy and Immunology Department of Laboratory Animal Care (RRID:SCR_014834) Copy   

•   Source: SciCrunch Registry