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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.bioconductor.org/packages/2.13/bioc/html/spliceR.html
An easy-to-use R package for classification of alternative splicing and prediction of coding potential from RNA-seq data.
Proper citation: spliceR (RRID:SCR_002280) Copy
http://cran.r-project.org/web/packages/neuRosim/
Software package that allows users to generate fMRI time series or 4D data. Some high-level functions are created for fast data generation with only a few arguments and a diversity of functions to define activation and noise. For more advanced users it is possible to use the low-level functions and manipulate the arguments.
Proper citation: neuRosim (RRID:SCR_002154) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowPlots.html
Software for analysis plots and data class for gated flow cytometry data.
Proper citation: flowPlots (RRID:SCR_002177) Copy
http://cran.r-project.org/web/packages/metaRNASeq/
Software package for meta-analysis of RNA-seq data. This package implements two p-value combination techniques (inverse normal and Fisher methods). It also provides a vignette explaining how to combine data from multiple RNA-seq experiments.
Proper citation: metaRNASeq (RRID:SCR_002174) Copy
https://cran.r-project.org/src/contrib/Archive/demi/
R package for estimating differential expression from multiple indicators that capitalizes on the high number of concurrent measurements. It extends to various experimental designs and target categories (transcripts, genes, genomic regions) as well as small sample sizes.
Proper citation: DEMI (RRID:SCR_002291) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowCore.html
A Bioconductor software package for high throughput flow cytometry that provides S4 data structures and basic functions.
Proper citation: flowCore (RRID:SCR_002205) Copy
http://www.statmethods.net/index.html
Training material created for both current R users, and experienced users of other statistical packages (e.g., SAS, SPSS, Stata) who would like to transition to R to help you quickly access this language in your work. The book inspired by this site takes the material here and significantly expands upon it.
Proper citation: Quick-R (RRID:SCR_002417) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowBeads.html
Software package for the analysis of flow cytometry bead data. It extends flowCore to provide functionality specific to bead data. One of the goals of this package is to automate analysis of bead data for the purpose of normalization.
Proper citation: flowBeads (RRID:SCR_002440) Copy
http://www.bioconductor.org/packages/release/bioc/html/flowCyBar.html
A software package to analyze flow cytometric data using gate information to follow population / community dynamics.
Proper citation: flowCyBar (RRID:SCR_002319) Copy
Couple of introductory tutorials on basic R concepts that provides an introduction to the R programming language, and illustrates its use by solving elementary statistics textbook exercises. Beyond the basics, they also cover topics of GPU computing in R. An R Tutorial eBook is also available.
Proper citation: R Tutorial - An R Introduction to Statistics (RRID:SCR_002394) Copy
http://www.bioconductor.org/packages/devel/bioc/html/MBASED.html
Software package containing functions for allele-specific gene expression (ASE) analysis using meta-analysis based allele-specific expression detection.
Proper citation: MBASED (RRID:SCR_002584) Copy
http://www.tractor-mri.org.uk/
Software application that includes R packages for reading, writing and visualising magnetic resonance images stored in Analyze, NIfTI and DICOM file formats (DICOM support is read only). It also contains functions specifically designed for working with diffusion MRI and tractography, including a standard implementation of the neighbourhood tractography approach to white matter tract segmentation. A shell script is also provided to run experiments with TractoR without interacting with R.
Proper citation: TractoR: Tractography with R (RRID:SCR_002602) Copy
http://bioconductor.org/packages/release/bioc/html/sapFinder.html
An R software package, for detection of the variant peptides based on tandem mass spectrometry (MS/MS)-based proteomics data. It automates (1) variation-associated database construction, (2) database searching, (3) post-processing, (4) HTML-based report generation in shotgun proteomics.
Proper citation: sapFinder (RRID:SCR_002685) Copy
http://www.bioconductor.org/packages/release/bioc/html/pathview.html
A tool set for pathway-based data integration and visualization. It maps and renders a wide variety of biological data on relevant pathway graphs. All users need is to supply their data and specify the target pathway. Pathview automatically downloads the pathway graph data, parses the data file, maps user data to the pathway, and render pathway graph with the mapped data. In addition, Pathview also seamlessly integrates with pathway and gene set (enrichment) analysis tools for large-scale and fully automated analysis.
Proper citation: Pathview (RRID:SCR_002732) Copy
http://www.bioconductor.org/packages/release/bioc/html/DSS.html
Software R library performing differntial analysis for count-based sequencing data. It detectes differentially expressed genes (DEGs) from RNA-seq, and differentially methylated loci or regions (DML/DMRs) from bisulfite sequencing (BS-seq). The core of DSS is a new dispersion shrinkage method for estimating the dispersion parameter from Gamma-Poisson or Beta-Binomial distributions.
Proper citation: DSS (RRID:SCR_002754) Copy
http://www.bioconductor.org/packages/devel/bioc/html/DMRforPairs.html
Software for identifying differentially methylated regions between unique samples using array based methylation profiles. It allows researchers to compare n greater than or equal to 2 unique samples with regard to their methylation profile. The (pairwise) comparison of n unique single samples distinguishesit from other existing pipelines as these often compare groups of samples in either single CpG locus or region based analysis. DMRforPairs defines regions of interest as genomic ranges with sufficient probes located in close proximity to each other. Probes in one region are optionally annotated to the same functional class(es). Differential methylation is evaluated by comparing the methylation values within each region between individual samples and (if the difference is sufficiently large), testing this difference formally for statistical significance.
Proper citation: DMRforPairs (RRID:SCR_005702) Copy
http://cran.r-project.org/web/packages/MetaQC/
Software for quality control and diagnosis for microarray meta-analysis. Quantitative quality control measures include: (1) internal homogeneity of co-expression structure among studies (internal quality control; IQC); (2) external consistency of co-expression structure correlating with pathway database (external quality control; EQC); (3) accuracy of differentially expressed gene detection (accuracy quality control; AQCg) or pathway identification (AQCp); (4) consistency of differential expression ranking in genes (consistency quality control; CQCg) or pathways (CQCp). For each quality control index, the p-values from statistical hypothesis testing are minus log transformed and PCA biplots were applied to assist visualization and decision. Results generate systematic suggestions to exclude problematic studies in microarray meta-analysis and potentially can be extended to GWAS or other types of genomic meta-analysis. The identified problematic studies can be scrutinized to identify technical and biological causes (e.g. sample size, platform, tissue collection, preprocessing etc) of their bad quality or irreproducibility for final inclusion / exclusion decision.
Proper citation: MetaQC (RRID:SCR_006000) Copy
http://cran.r-project.org/src/contrib/Archive/aCGH.Spline/
An R package for array comparative genomic hybridization (aCGH) dye bias normalization.
Proper citation: aCGH.Spline (RRID:SCR_002927) Copy
https://github.com/itojal/hot_scan
A free software to detect genomic regions unusually rich in translocation breakpoints. More generally, it may be used to detect a region that is unusually rich in a given character of a binary sequence.
Proper citation: hot scan (RRID:SCR_002840) Copy
http://www.bioconductor.org/packages/release/bioc/html/Basic4Cseq.html
An R/Bioconductor package for basic filtering, analysis and subsequent near-cis visualization of 4C-seq data. Virtual fragment libraries can be created for any BSGenome package, and filter functions for both reads and fragments and basic quality controls are included. Fragment data in the vicinity of the experiment's viewpoint can be visualized as a coverage plot based on a running median approach and a multi-scale contact profile.
Proper citation: Basic4Cseq (RRID:SCR_002836) Copy
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