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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.
http://www.sbg.bio.ic.ac.uk/3dgenomics/searchpage1.cgi
THIS RESOURCE IS NO LONGER IN SERVICE, documented August 29, 2016. Database containing structural annotations for the proteomes of just under 100 organisms. Using data derived from public databases of translated genomic sequences, representatives from the major branches of Life are included: Prokaryota, Eukaryota and Archaea. The annotations stored in the database may be accessed in a number of ways. The help page provides information on how to access the database. 3D-GENOMICS is now part of a larger project, called e-Protein. The project brings together similar databases at three sites: Imperial College London , University College London and the European Bioinformatics Institute . e-Protein''s mission statement is To provide a fully automated distributed pipeline for large-scale structural and functional annotation of all major proteomes via the use of cutting-edge computer GRID technologies. The following databases are incorporated: NRprot, SCOP, ASTRAL, PFAM, Prosite, taxonomy, COG The following eukaryotic genomes are incorporated: Anopheles gambiae, protein sequences from the mosquito genome; Arabidopsis thaliana, protein sequences from the Arabidopsis genome; Caenorhabditis briggsae, protein sequences from the C.briggsae genome; Caenorhabditis elegans protein sequences from the worm genome; Ciona intestinalis protein sequences from the sea squirt genome; Danio rerio protein sequences from the zebrafish genome; Drosophila melanogaster protein sequences from the fruitfly genome; Encephalitozoon cuniculi protein sequences from the E.cuniculi genome; Fugu rubripes protein sequences from the pufferfish genome; Guillardia theta protein sequences from the G.theta genome; Homo sapiens protein sequences from the human genome; Mus musculus protein sequences from the mouse genome; Neurospora crassa protein sequences from the N.crassa genome; Oryza sativa protein sequences from the rice genome; Plasmodium falciparum protein sequences from the P.falciparum genome; Rattus norvegicus protein sequences from the rat genome; Saccharomyces cerevisiae protein sequences from the yeast genome; Schizosaccharomyces pombe protein sequences from the yeast genome
Proper citation: 3D-Genomics Database (RRID:SCR_007430) Copy
http://www.agbase.msstate.edu/
A curated, open-source, web-accessible resource for functional analysis of agricultural plant and animal gene products. Our long-term goal is to serve the needs of the agricultural research communities by facilitating post-genome biology for agriculture researchers and for those researchers primarily using agricultural species as biomedical models. AgBase provides tools designed to assist with the analysis of proteomics data and tools to evaluate experimental datasets using the GO. Additional tools for sequence analysis are also provided. We use controlled vocabularies developed by the Gene Ontology (GO) Consortium to describe molecular function, biological process, and cellular component for genes and gene products in agricultural species. AgBase will also accept annotations from any interested party in the research communities. AgBase develops freely available tools for functional analysis, including tools for using GO. We appreciate any and all questions, comments, and suggestions. AgBase uses the NCBI Blast program for searches for similar sequences. And the Taxonomy Browser allows users to find the NCBI defined taxon ID for or taxon name for different organisms.
Proper citation: AgBase (RRID:SCR_007547) Copy
THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 16, 2013. The 7 database (or a7db) provides physiological, pharmacological and structural data pertaining to the 7 subunit of the nicotinic acetylcholine receptor. As well as the simple boolean-based query, there are several other ways to help you interrogate the database; * One page query builder * Query builder based on the category of data * Upload a prebuilt/previous query * Browse the database To gain insight into what sort of data can be queried, the one page or categorized query builders are recommended. Or you can just browse the database. The best way to navigate is to use the links on the left. Please be aware that we are presenting the raw data and that it is up to the user on how best to interpret that data. You can read more about the database in the recent article in BMC Neuroscience
Proper citation: Alpha-7 Database (RRID:SCR_007300) Copy
http://biobases.ibch.poznan.pl/5SData/
A database on nucleotide sequences of 5S rRNAs and their genes. The database contains 1985 primary structures of 5S rRNA and 5S rDNA, and was last updated in 2002, according to the website. They include 60 archaebacterial, 470 eubacterial, 63 plastid, nine mitochondrial and 1383 eukaryotic sequences. The nucleotide sequences of the 5S rRNAs or 5S rDNAs are divided according to the taxonomic position of the source organisms. The sequences for particular organisms can be retrieved as single files using a taxonomic browser or in multiple sequence structural alignments. The multiple sequence alignments of 5S ribosomal RNAs can be downloaded in TAB-delimited and FASTA formats.
Proper citation: 5S Ribosomal RNA Database (RRID:SCR_007545) Copy
http://www.ebi.ac.uk/Rebholz-srv/PaperMaker/
PaperMaker delivers feedback on the use of terms and language in a biomedical manuscript. It does not store any submitted data. PaperMaker is a novel IT solution that receives a scientific manuscript via a Web interface, automatically analyses the publication, evaluates consistency parameters and interactively delivers feedback to the author. It analyses the proper use of acronyms and their definitions, and the use of specialized terminology. It provides Gene Ontology (GO) and Medline Subject Headings (MeSH) categorization of text passages, the retrieval of relevant publications from public scientific literature repositories, and the identification of missing or unused references. The end result is that the author receives a summary of findings, the manuscript in its corrected form and a digital abstract containing the GO and MeSH annotations in the NLM/PubMed format.
Proper citation: PaperMaker (RRID:SCR_007269) Copy
Project aimed at making neuroimaging data sets of brain freely available to scientific community. By compiling and freely distributing neuroimaging data sets, future discoveries in basic and clinical neuroscience are facilitated.
Proper citation: Open Access Series of Imaging Studies (RRID:SCR_007385) Copy
http://mousespinal.brain-map.org/about.html
Platform for exploring spinal cord at cellular and molecular levels. Map of gene expression for adult and juvenile mouse spinal cord. Provides map of normal mouse when used to compare gene expression in diseased or injury models. Interactive database of gene expression mapped across all anatomic segments of mouse spinal cord at postnatal days 4 and 56. Indexed set of images based on RNA in situ hybridization data, searchable and sortable by gene, age, expression, cervical, thoracic, lumbar, sacral, and coccygeal segments.
Proper citation: Allen Mouse Spinal Cord Atlas (RRID:SCR_007418) Copy
http://www.ncbi.nlm.nih.gov/Web/Newsltr/Spring04/cancer.html
Cancer Chromosomes is an integration of three databases, the NCI/NCBI SKY/M-FISH & CGH Database, the NCI Mitelman Database of Chromosome Aberrations in Cancer, and the NCI Recurrent Aberrations in Cancer, which all focus on various aspects of cancer and cancer genes. The goal of the SKY/M-FISH and CGH database is to provide a public platform for investigators to share and compare their molecular cytogenetic data. The database is open to everyone and all users can view an individual investigator''s public data or compare public cases from different investigators. The information in the Mitelman Database of Chromosome Aberrations in Cancer relates chromosomal aberrations to tumor characteristics, based either on individual cases or associations. All the data have been manually culled from the literature. Complete karyotypes, patient characteristics, and references are found in the Mitelman Database of Chromosome Aberrations in Cancer. Users can search all three databases for cytogenetic, clinical, and/or reference information.
Proper citation: Cancer Chromosomes (RRID:SCR_007575) Copy
HubMed provides an interface to PubMed. Quick access to searches with a Firefox search plugin or a HubMed bookmarklet (drag to your browser''s bookmarks toolbar). Export citations in RIS, BibTeX, RDF and MODS formats, or directly to RefWorks. Unzip HubMed''s import filter into Endnote''s Filters folder for direct import into Endnote, or install the RIS Export plugin for direct import into ProCite, RefMan and older versions of Endnote. Use the Citation Finder to convert reference lists from PDFs into search results. Create lists of closely related papers using Rank Relations, then visualise and browse clusters of related papers using TouchGraph (requires Java). Graph occurrences of keywords in published papers over time. Tag and store annotated metadata for articles of interest.
Proper citation: HubMed (RRID:SCR_007296) Copy
Blog discussing preprints in population and evolutionary genetics.
Proper citation: Haldanes Sieve (RRID:SCR_007178) Copy
http://genome.mc.pref.osaka.jp/BGED/
THIS RESOURCE IS NO LONGER IN SERVICE, documented on June 08, 2011. This database contains gene expression data for various physiological and pathological processes in mouse brain. All the data have been obtained by adaptor-tagged competitive PCR, an advanced version of quantitative PCR. Brain Gene Expression Database (BGED) contains gene expression data for various physiological and pathological processes in mouse brain. All the data have been obtained by adaptor-tagged competitive PCR, an advanced version of quantitative PCR. Manual Download 1. Data retrieval Gene expression data can be retrieved either by ID numbers or by keywords representing functional annotations from this page. The ID numbers include GenBank, RefSeq, SwissProt, Gene Ontology, and BED (our own ID). The keyword search is based either on definition in GenBank, SwissProt and RefSeq, functional annotation of SwissProt database, or Gene Ontology terms. 2. Gene expression pattern display * Display of multiple gene expression patterns. Expression patterns of multiple genes selected by the keyword search can be displayed from the result page of the keyword search. * Gene expression pattern similarity search This function is available on the information page of each gene accessed through BED ID (in-house ID).
Proper citation: Brain Gene Expression Database (RRID:SCR_007299) Copy
http://www.med.nihon-u.ac.jp/department/physiol1/
Series of MRI slices from 3 male Japanese snow monkeys (Macaca fuscata). Images are provided of 2 mm MRI slices of male monkey brain in the coronal (N = 5), horizontal (N =1) and sagittal (N =1) planes. Slices are presented according to distance from interaural line. The slices are low resolution and no annotations are provided. Would be suitable for low resolution 3D reconstruction of monkey brain, however. Also, there are datasets provided for 5 monkeys total, 3 m.fuscata and 2 m. mulatta.
Proper citation: Stereotaxic MRI Brain Atlas of Monkey (RRID:SCR_007298) Copy
THIS RESOURCE IS NO LONGER IN SERVICE, documented August 26, 2016. CoC Central is a searchable database of residue conservation data covering the universe of known protein structures. CoC is useful for identifying functionally, kinetically, and thermodynamically important residues. Knowledge of universally conserved positions in protein folds may aid in identifying positions of kinetic or thermodynamic importance in protein folding, as well as those with a functional role.
Proper citation: CoC Central (RRID:SCR_007602) Copy
https://bioinformatics.cs.vt.edu/cmgs/CMGSDB/
CMGSDB is a database whose objective is to investigate gene silencing from a computational perspective using tools of computational biology and bioinformatics. The database is C. elegans centric, although the schema is suitable for any organism and can be extended with minor changes to support multiple organisms. CMGSDB contains details of genome annotation data (chromosomes, genes, coding transcripts), protein structure data (secondary structure, physical properties), microarray expression data (genomewide gene expressions for over 500 microarray experiments), RNA interferance data (RNAi experiment details, phenotypes exhibited by genes in different experiments, phenotype hierarchy and associations between them), protein-protein interaction data, and gene-regulation data.
Proper citation: CMGSDB- Computational Models for Gene Silencing (RRID:SCR_007601) Copy
COGEME is an ongoing BBSRC-funded study to construct a relational database of genomic information from phytopathogenic fungi. This site also hosts microarray data for Blumeria graminis. Expressed sequence tags (ESTs) obtained from eighteen species of plant pathogenic fungi, two species of phytopathogenic oomycete and three species of saprophytic fungi are included here. Hierarchical clustering software was used to classify together ESTs representing the same gene and produce a single contig, or consensus sequence. The unisequence set for each pathogen therefore represents a set of unique gene sequences, each one consisting of either a single EST or a contig sequence made from a group of ESTs. Unisequences were annotated based on top hits against the NCBI non-redundant protein database using blastx.
Proper citation: COGEME Phytopathogenic Fungi and Oomycete EST Database (RRID:SCR_007604) Copy
http://ppa.bcf.ku.edu/DB_PABP/
THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. DB-PABP is an attempt to document the publicly available experimentally determined polyanion binding proteins (PABPs). The purpose of the database is to provide life scientists who are interested in PA/PABP interactions with a comprehensive data repository, as well as computer scientists with a publicly available dataset to perform knowledge discovery and datamining studies. The database is manually curated. It uses protein annotations from NCBI protein database and literature information is retrieved from PubMed. Whenever applicable, links to NCBI protein database and PubMed are provided so users may access additional information available in these public databases.
Proper citation: DB-PABP: a database of polyanion binding proteins (RRID:SCR_007603) Copy
http://www.proteomicsresource.org/default.aspx
Biodefense Proteomics Resource Center presents information on Class A-C biodefense organisms. :This list includes Bacillus anthracis, Brucella abortus, Francisella tularensis, salmonella typhi, salmonella typhimurium, Virbio cholerae, Yersinia pestis, Cryptosporidium parvum, Toxoplasma gondii, Avian influenza, SARS, Monkeypox, Vaccinia, and Variola. For each organism, the page provides a general overview of the organism and the diseases it causes, protein (and protein interaction) data, reagents, and data from experiments performed with this organism. Users may also find links to the NCBI Taxonomy center.
Proper citation: Biodefense Proteomics Resource Center (RRID:SCR_007564) Copy
THIS RESOURCE IS NO LONGER IN SERVICE, documented May 10, 2017. A pilot effort that has developed a centralized, web-based biospecimen locator that presents biospecimens collected and stored at participating Arizona hospitals and biospecimen banks, which are available for acquisition and use by researchers. Researchers may use this site to browse, search and request biospecimens to use in qualified studies. The development of the ABL was guided by the Arizona Biospecimen Consortium (ABC), a consortium of hospitals and medical centers in the Phoenix area, and is now being piloted by this Consortium under the direction of ABRC. You may browse by type (cells, fluid, molecular, tissue) or disease. Common data elements decided by the ABC Standards Committee, based on data elements on the National Cancer Institute''s (NCI''s) Common Biorepository Model (CBM), are displayed. These describe the minimum set of data elements that the NCI determined were most important for a researcher to see about a biospecimen. The ABL currently does not display information on whether or not clinical data is available to accompany the biospecimens. However, a requester has the ability to solicit clinical data in the request. Once a request is approved, the biospecimen provider will contact the requester to discuss the request (and the requester''s questions) before finalizing the invoice and shipment. The ABL is available to the public to browse. In order to request biospecimens from the ABL, the researcher will be required to submit the requested required information. Upon submission of the information, shipment of the requested biospecimen(s) will be dependent on the scientific and institutional review approval. Account required. Registration is open to everyone., documented June 24, 2013 as per the Miriam database (http://www.ebi.ac.uk/miriam/main/collections/MIR:00000021). The CluSTr database offers an automatic classification of UniProt Knowledgebase and IPI proteins into groups of related proteins. The clustering is based on analysis of all pairwise comparisons between protein sequences. The database provides links to InterPro, which integrates information on protein families, domains and functional sites from PROSITE, PRINTS, Pfam, ProDom, SMART, TIGRFAMs, Gene3D, SUPERFAMILY, PIR Superfamily and PANTHER. To date (2011), CluSTr contains the following information: * 9,450,285 sequences from UniProt Knowledgebase release 15.6 * 308,281 sequences from IPI * 3,636,831,744 similarities, with pairwise alignments generated on-the-fly * 17,616,060 clusters * Clustering for 972 organisms with completely sequenced genomes. For the full list of the genomes see Integr8 * Putative homologues predictions for the above species. For more information see Homologue Selection at Integr8
Proper citation: CluSTr (RRID:SCR_007600) Copy
http://www.nia.nih.gov/research/nonhuman-primate-tissue-bank-handbook
A repository of tissue collected from nonhuman primate (NHP) species under contractual arrangement with Wisconsin National Primate Research Center (WI NPRC). NIA''''s Nonhuman Primate Tissue Bank collects and archives tissue from necropsies performed at primate centers nationwide. The goal is to collect various tissues from aged monkeys with smaller amounts of the same tissues from young and middle-aged monkeys. Tissue will be provided as: (1) fresh frozen, stored at ����?��������??80 degrees Celsius; (2) formalin fixed; or (3) fresh frozen tissue in OCT medium.Most frozen tissues are provided in approximately 1 gram of tissue per vial. Fixed tissue is available as slides (sections) from paraffin-embedded blocks. Slides can be stained if requested. Tissue from NIA''''s Nonhuman Primate Tissue Bank is available to investigators at academic and nonprofit research institutions who are engaged in funded research on aging. The project name and funding source must accompany all orders. The NIA will not be able to ship non-human primate tissue outside of the United States or US territories. Investigators at for-profit entities are not eligible to purchase tissue from NIA''''s Nonhuman Primate Tissue Bank unless it is for a Small Business Innovation Research grant from NIA. NIA provides the health information as given by the donor site and cannot guarantee other aspects of the health status not explicitly stated in the Vital Statistics Information Sheet. Concerns about the specific health status of donor animals should be indicated on the order form.
Proper citation: NIA Nonhuman Primate Tissue Bank (RRID:SCR_007324) Copy
http://senselab.med.yale.edu/odordb
OdorDb is a database of odorant molecules, which can be searched in a few different ways. One can see odorant molecules in the OdorDB, and the olfactory receptors in ORDB that they experimentally shown to bind. You can search for odorant molecules based on their attributes or identities: Molecular Formula, Chemical Abstracts Service (CAS) Number and Chemical Class. Functional studies of olfactory receptors involve their interactions with odor molecules. OdorDB contains a list of odors that have been identified as binding to olfactory receptors.
Proper citation: Odor Molecules DataBase (RRID:SCR_007286) Copy
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