Tools   Select Another Resource Report Type

http://www.BioMedSearch.com

BioMedSearch is a biomedical search engine that contains NIH/PubMed documents, plus a large collection of theses, dissertations, and other publications not found anywhere else for free, making it the most comprehensive free search on the web. :Besides free-form search, users can search based on Author, Journal Title, Publication Date, the Language in which the article was published (many non-English articles have English language abstracts), MeSH (Medical Subject Headings) and more. : The goal of BioMedSearch.com is to provide free access to a massive collection of authoritative documents relating to the biomedical field. Our mission is to make these important works available to the community in a way that is fast and easy, while still offering the advanced features demanded by power users such as portfolios, collaboration features, bibliographical citation export, alerts, and more. Whether you are doctor, scientist, or someone interested in researching a medical topic out of personal interest, BioMedSearch aggregates a vast number of authoritative documents in one place to make finding medical information easy, fast and free.

Proper citation: Biomedical Search: Medical Research and Health Resources (RRID:SCR_008683) Copy   

•   Source: SciCrunch Registry

http://www.molgen.ua.ac.be/ADMutations/default.cfm?MT=1&ML=0&Page=ADMDB

A locus-specific database aimed at collecting known mutations and non-pathogenic coding variations in the genes related to Alzheimer disease (AD) and frontotemporal dementia (FTD), following the guidelines of the Human Genome Variation Society. Mutations can be retrieved based on the gene, phenotype and publication. The database contains mutations reported in the literature and at scientific meetings, and unpublished mutations directly submitted to the database. To date, AD&FTDMDB contains mutations in the genes encoding the Amyloid Beta Precursor Protein (APP), Presenilin 1 (PSEN1), Presenilin 2 (PSEN2), Chromatin Modifying Protein 2B (CHMP2B), fusion (involved in t(12;16) in malignant liposarcoma) (FUS), Granulin (GRN), Microtubule Associated Protein Tau (MAPT), TAR DNA binding protein (TARDBP) and Valosin-containing Protein (VCP) and holds 415 different mutations observed in 1027 patients or families. As of March 2013, the latest publications referenced were from 2008, indicating that this resource may not be up to date.

Proper citation: Alzheimer Disease and Frontotemporal Dementia Mutation Database (RRID:SCR_008286) Copy   

•   Source: SciCrunch Registry

http://www.brainnav.com

THIS RESOURCE IS NO LONGER IN SERVICE, documented December 31, 2013. An interactive atlas and 3D brain software for research, structure analysis, and education, it offers six atlases representing four species: the mouse, rat, monkey and human. The stereotaxic coordinates atlases are available for all four species and the rodent models have additional chemoarchitectonic atlases. BrainNavigator helps locate specific areas of the brain, making visualizing and experimental planning in the brain easier. *Plan: Browse 6 Atlases, Visualize with 3D models, Search Literature, Analyze gene expression, Identify connections *Publish: Access reference tools, Use and print images for publication, Search literature *Propose: Use and print images for proposals, Search literature, Locate gene expression in 2D and 3D, Identify connections *Produce: Simulate injections, Customize new coordinates, virtually slice sections, overlay atlas maps on your own images, create personal atlas maps With BrainNavigator, you''ll gain 24/7 access to their powerful 3D brain interactive software tool that helps further research in the neurosciences. In addition, their vast library of widely respected and referenced brain publications will provide a plethora of information on the most current brain research available. As publisher of the gold standard in brain atlas publications authored by the team around the leading brain cartographers George Paxinos and Charles Watson, they are pleased to bring an advanced tool to today''s neuroscientists and educators. Combining atlas content and 3D capabilities based on technologies from the Allen Institute for Brain Science, this online workflow solution brings brain research, analysis and education tools to your fingertips.

Proper citation: BrainNavigator (RRID:SCR_008289) Copy   

•   Source: SciCrunch Registry

http://www.compneuro.org/CDROM/catacomb/index.html

Catacomb consists of a set of frameworks for various types of models in neuroscience, user interfaces to facilitate building models within these frameworks, and numerical algorithms to compute their behavior. The available frameworks include reaction kinetics, reaction diffusion systems, kinetic scheme models of ion channels, small neuron models and integrate and fire networks. It is a library of models (data structures and algorithms) covering a range of problems in neuroscience together with a versatile graphical user interface for constructing and running specific instances of the models. Some features of Catacomb include: * Class models. There is a growing set of classes containing data structures and calculation methods for various problem domains in neuroscience - reaction schemes, stochastic channel models, integrate-and-fire networks, cell geometry et al. * Dynamic interface builder. Using Java''s reflection capabilities, individual user interfaces are constructed for each class model allowing new instances to be created and displaying the results of any calculation methods they may contain. * Parameter watching. Using Java threads, the calculations are rerun and results displayed whenever parameters upon which they depend are changed. * Session recording. Operations can be recorded and played back for illustrating how to use Catacomb or for preconfigured demonstrations of model behavior. * Compatible with JPython. Catacomb does not include its own interpreter except in the minimal sense required to parse its own saved files. But its objects and methods are accessible to JPython which can be used for command line access or scripting. * Applet building. The contents of windows in the display can be extracted and packaged together in a single panel for loading as an applet. The model is saved as a java source file which, once compiled, can be packaged with the original Catacomb archive for loading from a Web page. See the AppletConfigEditor.

Proper citation: Components And Tools for Accessible COmputer Modeling in (neuro)Biology (RRID:SCR_008321) Copy   

•   Source: SciCrunch Registry

http://bioinf.xmu.edu.cn:8080/software/CYTOSVM/cytosvm.php

Cytokines are a diverse group of cell intercellular messengers responsible for signaling variety of cell functions, such as immunity, hematopoiesis, chemotactic activities, cell maturation, proliferation, growth and differentiation through their interactions with respective receptors on cell membranes. Currently, a number of cytokines have been identified and classified

Proper citation: CytoSVM statistics (RRID:SCR_008442) Copy   

•   Source: SciCrunch Registry

http://eaa.mpi-bn.mpg.de/

Service that allows you to process CEL files from Affymetrix, Inc. GeneChip Exon 1.0 ST Arrays to identify alternative splicing.

Proper citation: Exon Array Analyzer (RRID:SCR_008684) Copy   

•   Source: SciCrunch Registry

http://rsat.ulb.ac.be/rsat/

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Retrieve-ensembl-seq is included in the software suite regulatory sequence analysis tools (RSAT), allowing instant submission of retrieved sequences to further analysis tools. AVAILABILITY: retrieve-ensembl-seq is integrated in the RSAT suite: http://rsat.ulb.ac.be/rsat. Web site: http://rsat.ulb.ac.be/rsat/retrieve-ensembl-seq_form.cgi. Web services: http://rsat.ulb.ac.be/rsat/web_services/RSATWS.wsdl. Stand-alone distribution: freely available under an academic licence to download from the RSAT web site. The complete manual, a convenient tutorial and demos are available from the RSAT website. Additional help can be found on the RSAT public forum.

Proper citation: Regulatory Sequence Analysis Tools (RRID:SCR_008560) Copy   

•   Source: SciCrunch Registry

http://www.anxietyinsights.info/

THIS RESOURCE IS NO LONGER IN SERVICE, documented September 6, 2016.

Proper citation: Anxiety Insights (RRID:SCR_008717) Copy   

•   Source: SciCrunch Registry

http://www.vetmeduni.ac.at/en/vetcore/research/research-units/vetbiobank/

Not yet vetted by NIF curator

Proper citation: VetBioBank (RRID:SCR_008716) Copy   

•   Source: SciCrunch Registry

http://www.croptrust.org/main/

Not yet vetted by NIF curator

Proper citation: Israel Plant Gene Bank (RRID:SCR_008718) Copy   

•   Source: SciCrunch Registry

http://obomap.bioontology.org/

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 2, 2016. Service that determines the Suspected Overlap Among OBO Foundry Candidate Ontologies.

Proper citation: PROTOTYPE - Suspected Overlap Among OBO Foundry Candidate Ontologies (RRID:SCR_008834) Copy   

•   Source: SciCrunch Registry

http://www.stanford.edu/group/exonarray/cgi-bin/plot_selector.pl

Transcriptome database of acutely isolated purified astrocytes, neurons, and oligodendrocytes. Provides improved cell-type-specific markers for better understanding of neural development, function, and disease.

Proper citation: Exon Array Browser (RRID:SCR_008712) Copy   

•   Source: SciCrunch Registry

http://edboyden.org/05.09.boyden.html

Laser tool that enables neurons to be optically silenced by pulses of yellow light, the light-activated chloride pump halorhodopsin (Halo), in a paper entitled Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. We demonstrate reliable, millisecond-timescale control of neuronal spiking, as well as control of excitatory and inhibitory synaptic transmission. This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers. The quest to determine how precise neural activity patterns mediate computation, behavior, and pathology would be greatly aided by a set of tools for reliably activating and inactivating genetically targeted neurons, in a temporally precise and rapidly reversible fashion. Having earlier adapted a light-activated cation channel, 1channelrhodopsin-2 (ChR2), for allowing neurons to be stimulated by blue light, we searched for a complementary tool that would enable optical neuronal inhibition, driven by light of a second color. Here we report that targeting the 1codon-optimized form of the light-driven chloride pump halorhodopsin from the archaebacterium Natronomas pharaonis (hereafter abbreviated Halo) to genetically-specified neurons enables them to be silenced reliably, and reversibly, by millisecond-timescale pulses of yellow light. We show that trains of yellow and blue light pulses can drive high-fidelity sequences of hyperpolarizations and depolarizations in neurons simultaneously expressing yellow light-driven Halo and blue light-driven ChR2, allowing for the first time manipulations of neural synchrony without perturbation of other parameters such as spiking rates. The Halo/ChR2 system thus constitutes a powerful toolbox for multichannel photoinhibition and photostimulation of virally or transgenically targeted neural circuits without need for exogenous chemicals, enabling systematic analysis and engineering of the brain, and quantitative bioengineering of excitable cells.

Proper citation: Channelrhodopsin-2 enables optical activation of neurons (RRID:SCR_008833) Copy   

•   Source: SciCrunch Registry

http://www.functionalneurogenesis.com/blog/

A blog focusing on the function of adult neurogenesis in the dentate gyrus of the hippocampus, including discussion of scientific research papers, methods and protocols, and other trends or observations about the field.

Proper citation: Functional Neurogenesis (RRID:SCR_008830) Copy   

•   Source: SciCrunch Registry

http://cushing.med.yale.edu/gsdl/cgi-bin/library

The images in this collection are derived from high resolution scans of glass 3.25 X 4 inch lantern slides that were part of a large collection of slides covering his years at the Rockefeller University and Yale University School of Medicine. These selected images were scanned by James D. Jamieson, M.D., Ph.D., a student of Palade. The images also include some of the earliest electron micrographs taken by collaborators of George Palade both at the Rockefeller University (1945 - 1973) and at Yale (1973 - 1990). They include micrographs taken by Professor Marilyn Farquhar, Ph.D., whose studies elucidated the function of the glomerular basement membrane in renal filtration. There are 5 ways to find information in this collection: search for particular words that appear in the text by clicking the Search button; browse documents by Title by clicking the Titles button; browse documents by Subject by clicking the Subjects button; browse documents by Creator by clicking the Creators button, and browse documents by References by clicking the References button. Sponsors: This collection is the result of a collaboration between James D. Jamieson, M.D., Ph.D., Professor, Dept. of Cell Biology, and Arthur R. Belanger, OBE, Systems Manager, Harvey Cushing/John Hay Whitney Medical Library, both at the Yale University School of Medicine.

Proper citation: George E. Palade EM Slide Collection. (RRID:SCR_008675) Copy   

•   Source: SciCrunch Registry

http://recombineering.ncifcrf.gov/

Recombineering (recombination-mediated genetic engineering) is a powerful method for fast and efficient construction of vectors for subsequent manipulation of the mouse genome or for use in cell culture experiments. It is also an efficient way of manipulating the bacterial genome directly. Recombineering is a method based on homologous recombination in E. Coli using recombination proteins provided from ? phage. Our bacterial strains contain a defective ? prophage inserted into the bacterial genome. The phage genes of interest, exo, bet, and gam, are transcribed from the ?PL promoter. This promoter is repressed by the temperature-sensitive repressor cI857 at 32C and derepressed (the repressor is inactive) at 42C. When bacteria containing this prophage are kept at 32C no recombination proteins are produced. However, after a brief (15 minutes) heat-shock at 42C a sufficient amount of recombination proteins are produced. exo is a 5''-3'' exonuclease that creates single-stranded overhangs on introduced linear DNA. bet protects these overhangs and assists in the subsequent recombination process. gam prevents degradation of linear DNA by inhibiting E. Coli RecBCD protein. Linear DNA (PCR product, oligo, etc.) with sufficient homology in the 5'' and 3'' ends to a target DNA molecule already present in the bacteria (plasmid, BAC, or the bacterial genome itself) can be introduced into heat-shocked and electrocompetent bacteria using electroporation. The introduced DNA will now be modified by exo and bet and undergo homologous recombination with the target molecule. The method is so efficient that co-electroporation of a supercoiled plasmid and a linear piece of DNA into heat-shocked, electrocompetent bacteria will work as well.

Proper citation: Recombineering Information (RRID:SCR_008556) Copy   

•   Source: SciCrunch Registry

http://biobehavioural.blogspot.com/

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 6, 2016. Biobehavioral blog on research and medicine as a continuum from biological mechanisms to behavioural phenomena., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: Biobehavioral (RRID:SCR_008710) Copy   

•   Source: SciCrunch Registry

http://mips.helmholtz-muenchen.de/funcatDB/

THIS RESOURCE IS NO LONGER IN SERVICE, documented on August 19, 2019. The Functional Catalogue is an annotation scheme for the functional description of proteins of prokaryotic and eukaryotic origin. Taking into account the broad and highly diverse spectrum of known protein functions, the FunCat consists of 28 main functional categories (or branches) that cover general fields like cellular transport, metabolism and cellular communication/signal transduction. The main branches exhibit a hierarchical, tree like structure with up to six levels of increasing specificity. In total, the FunCat version 2.1 includes 1362 functional categories. This general concept was retained since the annotation of the Saccharomyces cerevisiae genome with only 4 revisions and later on also proved to be well suited for the annotation of genomes from different domains of life (Ruepp et al. 2004). The present and previous versions as well as a version mapping file of the FunCat and annotation data of our core projects can be downloaded via FTP. The MIPS Functional Catalogue Database provides a search tool to browse and search the Functional Categories including the FunCat Number, description, EC number, GO number or keywords associated with the categories. All FunCat annotated proteins and the amount of Co-annotated-FunCats can be retrieved starting with a specific category in a selected organism. A statistical survey of the functional distribution of a given set of genes/entries, e. g. a set of genes with up-regulated expression under a certain condition can be retrieved.

Proper citation: MIPS FunCat (RRID:SCR_008709) Copy   

•   Source: SciCrunch Registry

http://www.nordgen.org/index.php/en/content/view/full/467

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 18,2023.

Proper citation: Nordic Genetic Resource Center (RRID:SCR_008706) Copy   

•   Source: SciCrunch Registry

http://www.cnio.es/ES/grupos/plantillas/presentacion.asp?grupo=50004308

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 29, 2016. The need to use human neoplastic tissue under ideal conditions is currently of particular importance due to the development molecular pathology techniques that allow large-scale studies of genetic expression that are also of clinical significance. The Tumour Bank Network (TBN), instigated and coordinated by the Molecular Pathology Programme (MMP) aims to respond to this need by the promoting of Tumour Banks in Spanish hospitals. This will be achieved through the application of homogeneous procedures for the collection, processing and storage of neoplastic and normal tissue samples in such a way as to make molecular studies possible, avoiding that avoid the intrinsic bias of multi-centre studies possible. These Hospital Tumour Banks are based within the Pathology Departments of the collaborating Hospitals, that are interconnected through a computer-based network. In this way, each Centre''s tissue remains in the Hospital itself, thereby playing a key role in the development of the welfare, teaching and research activities within the Hospital. At the same time, it represents a tool to encourage of multi-hospital cancer research and of cooperation between basic and clinical researchers, constituting important collaboration between biomedical disciplines. The design does not correspond to a Central Tumour Bank, but that of a cooperative and coordinated Network of Hospital Banks, based on simple, homogeneous and optimal tissue treatment protocols. This Network is promoted by the Centro Nacional de Investigaciones Oncologicas (CNIO), which thereby undertakes the work of coordinating the network, using and maintaining the database, adhering to quality control. The aim of the CNIO's TBN is to acquire neoplastic and control non-neoplastic material of all types of malignant neoplasias, in the form of tissue fixed in formalin and paraffin embedded, of samples that are unfixed or frozen according to conventional methods as set out in Annexe 1 and even, exceptionally as fresh tissue. When other types of samples are required to carry out a specific project, the central office of the TBN will draw up a protocol with the group leading the project for the collection and maintenance of the tissue and clinicopathological data required for the proposed research. These protocols will be disseminated among the Associated Hospitals in order to gather the previously agreed number cases. Basic data surrounding the processing and preservation conditions for each case will be sent to the central office of the Bank, which under no circumstances will reveal the identity of the patient. Any Spanish cancer research team will be able to request tissue from the Tissue Bank Network. Absolute priority will be afforded to projects whose principal researcher belongs to one of the Associated Centres of the TNB, to other institutions with special agreements concerning the exchange of samples, and to the CNIO's researchers.

Proper citation: Spanish National Tumour Bank Network (RRID:SCR_008707) Copy   

•   Source: SciCrunch Registry