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http://www.uu.nl/faculty/veterinarymedicine/EN/labs_services/CCI/Documents/Instructie%20Leica%20DMRE%20fluorescentie%20microscoop.pdf

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 31,2025. Microscope that enables bright field and fluorescence imaging options.

Proper citation: Leica: DMRE Fluorescence Microscope (RRID:SCR_000011) Copy   

•   Source: SciCrunch Registry

http://edboyden.org/05.09.boyden.html

Laser tool that enables neurons to be optically silenced by pulses of yellow light, the light-activated chloride pump halorhodopsin (Halo), in a paper entitled Multiple-color optical activation, silencing, and desynchronization of neural activity, with single-spike temporal resolution. Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. We demonstrate reliable, millisecond-timescale control of neuronal spiking, as well as control of excitatory and inhibitory synaptic transmission. This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers. The quest to determine how precise neural activity patterns mediate computation, behavior, and pathology would be greatly aided by a set of tools for reliably activating and inactivating genetically targeted neurons, in a temporally precise and rapidly reversible fashion. Having earlier adapted a light-activated cation channel, 1channelrhodopsin-2 (ChR2), for allowing neurons to be stimulated by blue light, we searched for a complementary tool that would enable optical neuronal inhibition, driven by light of a second color. Here we report that targeting the 1codon-optimized form of the light-driven chloride pump halorhodopsin from the archaebacterium Natronomas pharaonis (hereafter abbreviated Halo) to genetically-specified neurons enables them to be silenced reliably, and reversibly, by millisecond-timescale pulses of yellow light. We show that trains of yellow and blue light pulses can drive high-fidelity sequences of hyperpolarizations and depolarizations in neurons simultaneously expressing yellow light-driven Halo and blue light-driven ChR2, allowing for the first time manipulations of neural synchrony without perturbation of other parameters such as spiking rates. The Halo/ChR2 system thus constitutes a powerful toolbox for multichannel photoinhibition and photostimulation of virally or transgenically targeted neural circuits without need for exogenous chemicals, enabling systematic analysis and engineering of the brain, and quantitative bioengineering of excitable cells.

Proper citation: Channelrhodopsin-2 enables optical activation of neurons (RRID:SCR_008833) Copy   

•   Source: SciCrunch Registry

https://mass-spec.stanford.edu/instruments

System includes SQD2 as single quadrupole MS with Waters H-Class Acquity UPLC, operated as open access platform for trained users. SQ Detector2 is single quadrupole mass detector for chromatography compatible with range of chromatography platforms and ionization sources.

Proper citation: Waters: SQD2 LC/MS system (RRID:SCR_022217) Copy   

•   Source: SciCrunch Registry

https://www.zeiss.com/microscopy/us/products/confocal-microscopes/lsm-900-with-airyscan-2.html

Laser scanning confocal microscope for multiplex imaging and analysis., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: Zeiss: LSM 900 with Airyscan 2 (RRID:SCR_022263) Copy   

•   Source: SciCrunch Registry

https://www.licor.com/bio/odyssey-xf/

System includes Odyssey XF Imager and Empiria Studio Software for streamlined image acquisition, organization, and analysis of Western blots. Used for imaging near infrared and enhanced chemiluminescent Western blots, to detect multiple targets on same blot with two channel multiplex fluorescence, and document DNA gels.

Proper citation: LI-COR: Odyssey XF Imaging System (RRID:SCR_022510) Copy   

•   Source: SciCrunch Registry

https://www.bdbiosciences.com/en-us/products/instruments/flow-cytometers/research-cell-analyzers/bd-facsymphony-a5-se

Flow cytometer gains full visible spectrum coverage to collect all light emitted without need for filter changes, increasing dye flexibility and number of simultaneous colors. Uses unmix spectral data live in BD FACSDiva Software while retaining familiar compensation workflow. May improve resolution of difficult cells and populations using autofluorescence unmixing.

Proper citation: BD Biosciences: FACSymphony A5 SE Cell Analyzer (RRID:SCR_022674) Copy   

•   Source: SciCrunch Registry

https://www.scireq.com/flexivent/

System for small animal pulmonary function. Used for in vivo respiratory mechanics measurements. Goes beyond traditional resistance and compliance mechanics of pulmonary ventilation, and captures details about mechanical properties of conducting airways, terminal airways and parenchyma. Achieves sensitivity and reproducibility by precisely controlling experimental conditions.

Proper citation: SciReq: flexiVent system (RRID:SCR_022673) Copy   

•   Source: SciCrunch Registry

https://www.biomerieux-usa.com/clinical/nuclisens-easymag

System for total nucleic acid extraction from variety of sample types and volumes. System automates enhanced magnetic silica version of bioMérieux’s proprietary BOOM technology gold standard for universal extraction of RNA and DNA.Clinical use includes nucleic acid extraction in front of molecular infectious disease assays, molecular oncology assays, molecular genetics assays.

Proper citation: BioMerieux: NucliSens easyMAG system (RRID:SCR_022666) Copy   

•   Source: SciCrunch Registry

https://www.wpiinc.com/var-2273-constant-current-stimulus-isolator

Automated bipolar pulsing for zero net charge on biological preparations. Includes Constant current, Unipolar and bipolar stimulation modes, Built-in non-compliance alarm, Optically isolated input Standard TTL triggering, DC test mode. Powered by 9 V alkaline or rechargeable batteries.

Proper citation: WPI: Constant Current Stimulus Isolator (RRID:SCR_022660) Copy   

•   Source: SciCrunch Registry

https://www.fluidigm.com/products-services/instruments/biomark-hd

Automated, high performance PCR/qPCR system that uses microfluidics technology to process samples at nanoliter scale volumes for gene expression, genotyping, sample identification, copy number variation analysis and digital PCR. With wide range of integrated fluidic circuit (IFC) formats available, scaling from mid to high throughput on single system.

Proper citation: Standard BioTools: Biomark HD system (RRID:SCR_022658) Copy   

•   Source: SciCrunch Registry

https://us.ohaus.com/en-US/Products/Balances-Scales/Portable-Balances/CS-Series/CS200P

OHAUS CS lightweight, portable, compact balance for use in laboratory, industrial, education and home use applications. CS offers great value without sacrificing accuracy for weighing jobs of 200g to 5000g.

Proper citation: OHAUS: CS200P Portable Balance (RRID:SCR_022536) Copy   

•   Source: SciCrunch Registry

https://www.npielectronic.com/product/pdes-module/

Pneumatic drug ejection. Used to apply ionic and non-ionic substances in small amounts. Locally precise application with microJECT pipette holder with built-in valve. Also available as 19″ stand alone device.

Proper citation: NPI: Pressure Application Module (RRID:SCR_022657) Copy   

•   Source: SciCrunch Registry

https://www.artec3d.com/portable-3d-scanners/artec-eva

3D scanner for making quick, textured, and accurate 3D models of medium sized objects such as human bust, alloy wheel, or motorcycle exhaust system. Used for capturing objects of almost any kind, including objects with black and shiny surfaces.

Proper citation: Artec 3D: Eva Fast 3D scanner (RRID:SCR_022589) Copy   

•   Source: SciCrunch Registry

https://www.artec3d.com/portable-3d-scanners/artec-spider

3D scanner based on blue light technology. Precision instrument for CAD users and engineers. Used for capturing small objects or intricate details of large industrial objects in high resolution, with accuracy and brilliant color.

Proper citation: Artec 3D: Space Spider (RRID:SCR_022588) Copy   

•   Source: SciCrunch Registry

https://www.rcon-ndt.com/products/radiography/x-ray-systems/phoenix-nanotom-s/

Nanofocus computed tomography system for applications in material science, precision injection moulding, micromechanics, electronics geology and biology. System includes nanofocus X-ray tube, precision mechanics and advanced software modules. Used for range of 3D CT applications., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: GE: Phoenix Nanotom S system (RRID:SCR_022582) Copy   

•   Source: SciCrunch Registry

https://www.thermofisher.com/order/catalog/product/A24811

Bentchtop Thermal Cycler for everyday PCR. Features innovative, safe heated lid and large LCD color touch screen.

Proper citation: Thermo Fisher: Applied Biosystems: SimpliAmp Thermal Cycler (RRID:SCR_023004) Copy   

•   Source: SciCrunch Registry

https://www.visualsonics.com/product/imaging-systems/vevo-770

High resolution in vivo imaging system for small animal research. Provides visualization and measurement of anatomical and hemodynamic function in small animals down to 30 microns.

Proper citation: Fujifilm: VisualSonics Vevo 770 Imaging System (RRID:SCR_022921) Copy   

•   Source: SciCrunch Registry

https://moticeurope.com/en/moticeasyscan-pro-6-fs.html

MoticEasyScan digital slides scanner.

Proper citation: Motic: MoticEasyScan Pro 6-FS (RRID:SCR_022814) Copy   

•   Source: SciCrunch Registry

https://www.bruker.com/en/products-and-solutions/preclinical-imaging/mri/biospec/biospec-70-20-and-94-20.html

Multipurpose research system for high resolution Magnetic Resonance Spectroscopy and Imaging. System is equipped with 7 Tesla superconducting magnet designed with Ultra Shielded Refrigerated magnet technology. USR technology significantly reduces stray field to close to magnet. Used for In Vivo Magnetic Resonance Imaging.

Proper citation: Bruker: 7 Tesla Bruker BioSpec 70/20 USR MRI system (RRID:SCR_022895) Copy   

•   Source: SciCrunch Registry

https://www.iveindhoven.com/en/article/reichert-jung-ultracut-e-ultramicrotome/

Reichert Jung Ultracut E, article number 131-960, is used to cut ultrathin and semithin sections of resin embedded samples for electron microscopy.

Proper citation: Ultracut: E ultramicrotome (RRID:SCR_022980) Copy   

•   Source: SciCrunch Registry