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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Authority Synonyms Record Last Update Mentions Count
Pilon
 
Resource Report
Resource Website
1000+ mentions
Pilon (RRID:SCR_014731) data analysis software, data processing software, sequence analysis software, software application, software resource Software tool to automatically improve draft assemblies and find variation among strains, including large event detection. FASTA files of genome along with one or more BAM files of reads aligned as input. Read alignment analysis is used to identify inconsistencies between input genome and evidence in reads, then attempts to make improvements to genome. automatically, improve, draft, assembly, variation, strain, genome, read, alignment, analysis, inconsistency, bio.tools is listed by: Debian
is listed by: bio.tools
is listed by: OMICtools
is related to: shovill
is hosted by: GitHub
DOI:10.1371/journal.pone.0112963
DOI:10.1371/journal.pone.0112963
Available for download, Acknowledgement requested OMICS_14553, biotools:pilon https://github.com/broadinstitute/pilon/wiki, https://bio.tools/pilon, https://sources.debian.org/src/pilon/ SCR_014731 SciCrunch Registry 2026-10-31 12:18:30 3377
Roary
 
Resource Report
Resource Website
500+ mentions
Roary (RRID:SCR_018172) data analysis software, data processing software, sequence analysis software, software application, software resource Software tool for rapid large scale prokaryote pan genome analysis. Builds large scale pan genomes, identifying core and accessory genes. Makes construction of pan genome of thousands of prokaryote samples on standard desktop without compromising on accuracy of results. Not intended for meta genomics or for comparing extremely diverse sets of genomes. Genome analysis, prokaryote pan genome, pan genome, gene identification, analysis, bio.tools is listed by: Debian
is listed by: bio.tools
is listed by: OMICtools
works with: Scoary
Wellcome Trust PMID:26198102 Free, Available for download, Freely available OMICS_09491, biotools:roary https://github.com/sanger-pathogens/Roary, https://bio.tools/roary, https://sources.debian.org/src/roary/ SCR_018172 SciCrunch Registry 2026-10-31 12:18:43 710
StringTie
 
Resource Report
Resource Website
1000+ mentions
StringTie (RRID:SCR_016323) data analysis software, data processing software, sequence analysis software, software application, software resource Software application for assembling of RNA-Seq alignments into potential transcripts. It enables improved reconstruction of a transcriptome from RNA-seq reads. This transcript assembling and quantification program is implemented in C++ . assembling, RNA, sequence, transcript, gene, alignment, reconstruction, read, analysis, process, bio.tools is listed by: bio.tools
is listed by: Debian
is listed by: OMICtools
NCI R01 CA120185;
NCI R01 CA134292;
NHGRI R01 HG006102;
NHGRI R01 HG006677;
NIGMS R01 GM105705;
the Cancer Prevention and Research Institute of Texas
PMID:25690850
DOI:10.1038/nbt.3122
Open source, Free, Freely available, Available for download biotools:stringtie, OMICS_07226 https://github.com/gpertea/stringtie, https://bio.tools/stringtie, https://sources.debian.org/src/stringtie/ SCR_016323 SciCrunch Registry 2026-10-31 12:18:32 4976
fastp
 
Resource Report
Resource Website
1000+ mentions
fastp (RRID:SCR_016962) data analysis software, data processing software, software application, software resource Software tool to provide fast all in one preprocessing for FastQ files. Developed in C++ with multithreading supported to afford high performance. Performs quality control, adapter trimming, quality filtering, per read quality pruning and many other operations with a single scan of the FASTQ data. fast, all in one, preprocessing, FastQ, file, data, read, quality, control, adapter, trimming, filtering is listed by: OMICtools National Science Foundation of China ;
Special Funds for Future Industries of Shenzhen
PMID:30423086 Free, Available for download, Freely available SCR_016962 SciCrunch Registry 2026-10-31 12:18:34 1745
Hinge
 
Resource Report
Resource Website
1+ mentions
Hinge (RRID:SCR_016135) data analysis software, data processing software, sequence analysis software, software application, software resource Software application for long read genome assembly based on hinging. Used in long-read sequencing technologies in genome assemblies to achieve optimal repeat resolution. long, read, genome, assembly, hinging, sequence, optimal, repeat, resolution is listed by: Debian
is listed by: OMICtools
PMID:28320918 Free, Available for download OMICS_12339 https://sources.debian.org/src/hinge/ SCR_016135 SciCrunch Registry 2026-10-31 12:18:32 9
pheatmap
 
Resource Report
Resource Website
1000+ mentions
pheatmap (RRID:SCR_016418) pheatmap data acquisition software, data processing software, image acquisition software, software application, software resource, software toolkit Software tool as a function in R to draw clustered heatmaps for better control over graphical parameters. draw, clustered, heatmap, control, graphical, parameter, size, shape, text, bio.tools is used by: ClustVis
is listed by: Debian
is listed by: bio.tools
is listed by: OMICtools
is listed by: SoftCite
is related to: CRAN
Free, Available for download, Freely available biotools:pheatmap, OMICS_26726 https://github.com/raivokolde/pheatmap, https://cran.r-project.org/web/packages/pheatmap/pheatmap.pdf, https://bio.tools/pheatmap, https://sources.debian.org/src/r-cran-pheatmap/ SCR_016418 SciCrunch Registry pretty heatmap 2026-10-31 12:18:42 1249
duphold
 
Resource Report
Resource Website
1+ mentions
duphold (RRID:SCR_016938) data analysis software, data processing software, software application, software resource Software tool to annotate structural variant calls with sequence depth information that can add or remove confidence to SV predicted to affect copy number. Indicates the presence of a rapid change in depth relative to the regions surrounding the breakpoints. Allows the run time to be nearly independent of the number of variants important for large, jointly called projects with many samples. Annotates structural variant predictions made from both short read and long read data. annotate, structural, variation, call, sequence, depth, confidence, predict, copy, number, short, long, read, data is listed by: OMICtools Free, Available for download, Freely available SCR_016938 SciCrunch Registry 2026-10-31 12:18:33 3
FreeContact
 
Resource Report
Resource Website
10+ mentions
FreeContact (RRID:SCR_016113) alignment software, data processing software, image analysis software, software application, software resource Alignment software for large-scale protein contact or protein-protein interaction prediction optimized for speed through shorter runtimes. FreeContact provides the opportunity to compute contact predictions in any environment (desktop or cloud). protein, structure, prediction, sequence, analysis, fast, contact, alignment, multiple is listed by: OMICtools
is related to: Debian
Alexander von Humboldt Foundation ;
German Ministry for Research and Education (BMBF: Bundesministerium fuer Bildung und Forschung) ;
Research Council of Norway 208481
PMID:24669753
DOI:10.1186/1471-2105-15-85
Open source, Free, Available for download OMICS_03520 https://rostlab.org/owiki/index.php/FreeContact, https://sources.debian.org/src/libfreecontact-perl/ SCR_016113 SciCrunch Registry 2026-10-31 12:18:42 22
ClonalOrigin
 
Resource Report
Resource Website
1+ mentions
ClonalOrigin (RRID:SCR_016061) data analysis software, data processing software, sequence analysis software, software application, software resource Software package for comparative analysis of the sequences of a sample of bacterial genomes in order to reconstruct the recombination events that have taken place in their ancestry. comparative, analysis, sequence, bacteria, genome, reconstruct, recombination, events, ancestry, bayesian is listed by: Debian
is listed by: OMICtools
is related to: Imperial College London; London; United Kingdom
is related to: Wellcome Trust Sanger Institute; Hinxton; United Kingdom
National Science Foundation DBI-0630765;
Science Foundation of Ireland 05/FE1/B882;
Wellcome Trust WT082930MA
PMID:20923983
DOI:10.1534/genetics.110.120121
Free, Available for download OMICS_18881 https://sources.debian.org/src/clonalorigin/ SCR_016061 SciCrunch Registry 2026-10-31 12:18:33 8
mlgt
 
Resource Report
Resource Website
mlgt (RRID:SCR_001211) mlgt data processing software, software application, software resource Software for processing and analysis of high throughput (Roche 454) sequences generated from multiple loci and multiple biological samples. Sequences are assigned to their locus and sample of origin, aligned and trimmed. Where possible, genotypes are called and variants mapped to known alleles. roche, windows, os x, genotype, variant, allele, high throughput sequencing, locus, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: University of Manchester; Manchester; United Kingdom
THIS RESOURCE IS NO LONGER IN SERVICE BioTools:mlgt, OMICS_02131, biotools:mlgt https://bio.tools/mlgt, https://bio.tools/mlgt, https://bio.tools/mlgt SCR_001211 SciCrunch Registry Multi-Locus Geno-Typing, mlgt: Multi-Locus Geno-Typing 2026-10-31 12:19:05 0
RDPipeline
 
Resource Report
Resource Website
10+ mentions
RDPipeline (RRID:SCR_001192) RDPipeline data processing software, software application, software resource Software to simplify the processing of large rRNA sequence libraries (including single-strand and paired-end reads) obtained through high-throughput sequencing technology. Tools for assembly, quality filtering, taxonomy based analysis and taxonomy independent analysis tools, and tools to convert the data to formats suitable for common ecological and statistical packages are available. For extremely large datasets, command line tools are available. amplicon sequencing, high-throughput sequencing, rrna, assembly, quality filtering, taxonomy, analysis, FASEB list is listed by: OMICtools
has parent organization: Ribosomal Database Project
PMID:24288368 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_02158 SCR_001192 SciCrunch Registry RDP Pipeline, RDP Amplicon Sequence Pipeline 2026-10-31 12:19:05 39
Plantagora
 
Resource Report
Resource Website
1+ mentions
Plantagora (RRID:SCR_001227) Plantagora data or information resource, data set, software resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 18,2025. A web-based plant genome assembly simulation platform whose resources include out of the box scripts for analyzing assembly data, an on-demand web graphing tool to model your experiment, and a downloadable database with metrics and parameters from over 3,000 simulated genome assemblies. next-generation sequencing, genome assembly, sequencing, genome, 454, illumina, simulate is listed by: OMICtools
has parent organization: University of Arizona; Arizona; USA
PMID:22174807 THIS RESOURCE IS NO LONGER IN SERVICE OMICS_02116 SCR_001227 SciCrunch Registry Plantagora - a resource for plant genome assembly 2026-10-31 12:19:05 1
Avadis
 
Resource Report
Resource Website
1+ mentions
Rating or validation data
Avadis (RRID:SCR_000644) Avadis software library, software resource, software toolkit Software integrated platform that provides analysis, management and visualization tools for next-generation sequencing data. It supports workflows for RNA-Seq, DNA-Seq, ChIP-Seq and small RNA-Seq experiments. Avadis has a built-in Gene Ontology browser to view ontology hierarchies. There are common ontology paths for multiple genes. Platform has collection of data / text mining algorithms, data visualization libraries, workflow/application automation layers, and enterprise data organization functions. These functions are available as libraries that allow developers to rapidly build software prototypes, applications and off-the-shelf products. The collection of algorithms and visualizations in AVADIS grows as new applications using the platform are developed. Currently, the algorithms that AVADIS platform contains range from general purpose statistical mining and modelling algorithms, to text mining algorithms, to very application-specific algorithms for microarray / NGS data analysis, QSAR modelling and biological networks analysis. AVADIS has a collection of powerful mining algorithms like PCA, ANOVA, T-test, clustering, classification and regression methods. The range of visualizations includes most statistical and data modelling related graphing views, and very application-specific visualizations. Some of the statistical views include 2D/3D scatter plots, profile plots, heat maps, histograms and matrix plot; data modelling relevant views include dendrograms, cluster profiles, similarity images and SOM U-matrices. Application-specific views in AVADIS include pathway network views, genome browsers, chemical structure views and pipe-line views. Platform: Windows compatible, Mac OS X compatible, Linux compatible, pathway network views, genome browsers, chemical structure views, pipe-line views, next-generation sequencing data, integrated platform, view ontology hierarchies, statistical mining and modelling, collection of data, text mining algorithms collection, data visualization libraries, is listed by: Gene Ontology Tools
is listed by: OMICtools
is related to: Gene Ontology
THIS RESOURCE IS NO LONGER IN SERVICE OMICS_01120, nlx_149208 http://www.strandls.com/Avadis SCR_000644 SciCrunch Registry Access Visualize Analyze Discover, Avadis NGS 2026-10-31 12:19:04 2
MaryGold
 
Resource Report
Resource Website
1+ mentions
MaryGold (RRID:SCR_000528) MaryGold software resource, software toolkit Software package that enables detection of sequence variation between metagenomic samples. sequence variation, metagenomic, c++, python is listed by: OMICtools
has parent organization: SourceForge
Free, Available for download, Freely available, OMICS_01495 SCR_000528 SciCrunch Registry MaryGold - Variation analysis of metagenomic samples 2026-10-31 12:19:06 1
MAIA (Microarray Image Analysis)
 
Resource Report
Resource Website
1+ mentions
MAIA (Microarray Image Analysis) (RRID:SCR_002239) MAIA data processing software, image analysis software, software application, software resource Software package for automatic processing of the one- and two- (typically, Cy3-green/Cy5-red) color images produced in cDNA, CGH (comparative genome hybridization) or protein microarray technologies. It incorporates the following modules: * The spot localization module (i) identifies the position of each spot on the array, so that the name of the spotted clone can be associated with the correspondent spot; and (ii) establishes the borders between the neighborhood spots letting one to perform further data processing procedures (i.e. to extract quantitative information) for each spot independently of the other neighborhood spots. Visually this results in the generation of a grid covering the image. The spot localization algorithm is fully automatic and robust with respect to deviations from perfect spot alignment and contamination. As an input, it requires only the common array design parameters: number of blocks and number of spots in the x and y directions of the array. * The spot quantification module for one-color images performs segmentation of the spots and estimates the averaged spot and local background intensities. The spot quantification module for two-color images estimates the ratio of the measured intensities in the two color channels at each spot reflecting differential gene (cDNA technology) or protein expression or a change in DNA copy number (CGH experiments) between the test and control samples for the corresponding gene. This module includes algorithms based on the linear regression and segmentation of the spots. A special procedure for detection and removal of the aberrant pixels has been developed to make ratio estimates more resistant to array contamination. It ensures more consistent ratio estimates obtained from different algorithms, and allows delivery of a single trustable ratio value. * The quality control module provides a value of spot quality reflecting the level of confidence in the obtained quantitative estimates at each spot. These quality values can be used either directly to flag out some spots with the quality lower than the user-defined threshold, or in the follow-up analysis as a weight controlling the contribution/influence of the obtained ratio estimates. The unique spot quality value for a spot is derived from a set of marginal quality parameters characterizing certain features of the spot. The contribution of each quality parameter in the overall quality is automatically evaluated based on the user visual classification of the spots, or using information available from the replicated spots, located at the same array or over a set of replicated arrays. * The image simulator allows the generation of a broad spectrum of microarray images with different types of contamination (like non-specific hybridization and dust) and noise. Since in simulation experiment the true values of the ratios are known exactly, it allows one to evaluate, to test and to compare different algorithms for microarray image processing objectively. microarray, cdna, comparative genome hybridization, protein microarray is listed by: OMICtools
has parent organization: Curie Institute; Paris; France
PMID:17237062
PMID:16374914
Free, Available for download, Freely available OMICS_00843 SCR_002239 SciCrunch Registry Microarray Image Analysis 2026-10-31 12:19:06 3
biobambam
 
Resource Report
Resource Website
50+ mentions
biobambam (RRID:SCR_003308) data processing software, software application, software resource Software tools for read pair collation based algorithms on BAM files including * bamcollate2: reads BAM and writes BAM reordered such that alignment or collated by query name * bammarkduplicates: reads BAM and writes BAM with duplicate alignments marked using the BAM flags field * bammaskflags: reads BAM and writes BAM while masking (removing) bits from the flags column * bamrecompress: reads BAM and writes BAM with a defined compression setting. This tool is capable of multi-threading. * bamsort: reads BAM and writes BAM resorted by coordinates or query name * bamtofastq: reads BAM and writes FastQ; output can be collated or uncollated by query name standalone software, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
DOI:10.1186/1751-0473-9-13 Free, Available for download, Freely available biotools:biobambam, OMICS_04664 https://bio.tools/biobambam, https://sources.debian.org/src/biobambam2/ SCR_003308 SciCrunch Registry 2026-10-31 12:19:08 65
FASTX-Toolkit
 
Resource Report
Resource Website
1000+ mentions
FASTX-Toolkit (RRID:SCR_005534) data processing software, software application, software resource, software toolkit Software tool as collection of command line tools for Short-Reads FASTA/FASTQ files preprocessing. Short reads, FASTA file, FASTQ file, preprocessing, command line tools, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Cold Spring Harbor Laboratory
SCR_019035, SCR_015042, biotools:fastx-toolkit, OMICS_01045 https://github.com/agordon/fastx_toolkit, https://bio.tools/fastx-toolkit SCR_005534 SciCrunch Registry FASTQ/A short-reads pre-processing tools 2026-10-31 12:19:10 2864
Sickle
 
Resource Report
Resource Website
1000+ mentions
Sickle (RRID:SCR_006800) Sickle data processing software, software application, software resource Software tool for windowed adaptive trimming for fastq files using quality. Supports quality values like Illumina, Solexa, and Sanger. Takes the quality values and slides a window across them whose length is 0.1 times the length of the read. bio.tools, windowed, adaptive, trimming, FASTQ, quality, value, read is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
Free, Available for download, Freely available OMICS_01077, biotools:sickle, SCR_016901 https://bio.tools/sickle, https://sources.debian.org/src/sickle/ SCR_006800 SciCrunch Registry sickle - A windowed adaptive trimming tool for FASTQ files using quality 2026-10-31 12:19:11 1664
STRAP
 
Resource Report
Resource Website
100+ mentions
STRAP (RRID:SCR_005675) STRAP data processing software, software application, software resource Software program that automatically annotates a protein list with information that helps in the meaningful interpretation of data from mass spectrometry and other techniques. It takes protein lists as input, in the form of plain text files, protXML files (usually from the TPP), or Dat files from MASCOT search results. From this, it generates protein annotation tables, and a variety of GO charts to aid individual and differential analysis of proteomics data. It downloads information from mainly the Uniprot and EBI QuickGO databases. STRAP requires Windows XP or higher with at least version 3.5 of the Microsoft .NET Framework installed. Platform: Windows compatible protein, gene, annotation, mass spectrometry, proteomics, visualization, browser, differential analysis, analysis, ontology or annotation browser, ontology or annotation visualization, differential analysis of proteomics data sets, windows, protein annotation, data visualization, c#, pathway, FASEB list is listed by: Gene Ontology Tools
is listed by: OMICtools
is related to: Gene Ontology
is related to: UniProt
is related to: QuickGO
has parent organization: Boston University School of Medicine; Massachusetts; USA
NHLBI contract N01 HV28178;
NCRR P41 RR10888
PMID:19839595 Open unspecified license, Acknowledgement requested OMICS_02277, nlx_149115 SCR_005675 SciCrunch Registry Software Tool for Rapid Annotation of Proteins, STRAP for GO Annotation, STRAP - Software Tool for Rapid Annotation of Proteins 2026-10-31 12:19:10 122
SOAP3
 
Resource Report
Resource Website
1+ mentions
SOAP3 (RRID:SCR_005502) SOAP3 data processing software, software application, software resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 12,2024. GPU-based software for aligning short reads with a reference sequence. It can find all alignments with k mismatches, where k is chosen from 0 to 3. gpu/cuda, next generation sequencing, alignment, short read, gpu is listed by: OMICtools
has parent organization: SOAP
PMID:22285832 THIS RESOURCE IS NO LONGER IN SERVICE SCR_005502 SciCrunch Registry 2026-10-31 12:19:10 7

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