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Cellosaurus is database indexing available cell lines from various collections: American Type Culture Collection (ATCC), Bioresource Collection and Research Center, Taiwan (BCRC), Banco de Células do Rio de Janeiro (BCRJ), CellBank Australia (CBA), Collection of Cell Lines in Veterinary Medicine (CCLV), Cell Lines Service (CLS), Coriell, Drosophila Genomics Resource Center (DGRC), Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSMZ), European Bank for induced pluripotent Stem Cells (EBiSC), European Collection of Authenticated Cell Cultures (ECACC), Interlab Cell Line Collection (ICLC), Institute for Fermentation Osaka (IFO), Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER) biobank, Japanese Collection of Research Bioresources (JCRB) Cell Bank, Kunming Cell Bank of Type Culture Collection (KCB), Korean Cell Line Bank (KCLB), Millipore, National Cell Bank of Iran (NCBI_Iran), National Cancer Institute - Developmental Therapeutics Program (NCI-DTP), NINDS Human Cell and Data Repository (NHCDR), NIH AIDS Reagent Program (NIH-ARP), NISES, RIKEN Bioresource Center Cell Bank (RCB), Royan Stem Cell Bank (RSCB), Tick Cell Biobank (TCB), Tohoku University cell line catalog (TKG), and Ximbio.
https://web.expasy.org/cellosaurus/CVCL_E3E9
Organism: Homo sapiens (Human)
Disease: Ovarian serous cystadenocarcinoma
Category: Cancer cell line
Comments: Characteristics: Transfected with the pVgRXR vector that contains the VgEcR fusion protein under the control of a CMV promoter and RXRA under the control of a RSV promoter as well as BleoR. Also transfected with an empty pIND vector (PubMed=15755800)., Characteristics: Control cell line for SK-OV-3/pVgRXR/pINDp53wt (Cellosaurus=CVCL_E3EA) (PubMed=15755800)., Population: Caucasian.
Proper citation: RRID:CVCL_E3E9 Copy
https://web.expasy.org/cellosaurus/CVCL_G366
Organism: Homo sapiens (Human)
Disease: Renal cell carcinoma
Category: Cancer cell line
Comments: Caution: The age/sex of donor of this cell line and that of NKK1 (Cellosaurus=CVCL_G365), both described in PubMed=9183637 are inverted in the abstract of that paper. We believe that the information in the material and methods section is the correct one as it is corroborated by the karyotype information in the same paper., Population: Japanese.
Proper citation: RRID:CVCL_G366 Copy
https://web.expasy.org/cellosaurus/CVCL_G366
Organism: Homo sapiens (Human)
Disease: Renal cell carcinoma
Category: Cancer cell line
Comments: Caution: The age/sex of donor of this cell line and that of NKK1 (Cellosaurus=CVCL_G365), both described in PubMed=9183637 are inverted in the abstract of that paper. We believe that the information in the material and methods section is the correct one as it is corroborated by the karyotype information in the same paper., Population: Japanese.
Proper citation: TKG Cat# TKG 0700, RRID:CVCL_G366 Copy
Possibly Discontinued
https://web.expasy.org/cellosaurus/CVCL_6805
Organism: Homo sapiens (Human)
Disease: Melanoma
Category: Cancer cell line
Comments: Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in Cellosaurus and May 2018. The major changes were: Amelogenin., Population: Caucasian., Part of: Wistar Institute melanoma cell line collection., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Proper citation: RRID:CVCL_6805 Copy
https://web.expasy.org/cellosaurus/CVCL_E8DB
Organism: Homo sapiens (Human)
Category: Transformed cell line
Comments: Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of the ISG54 promoter (InvivoGen=hkb-ifnabv2)., Characteristics: Designed to detect bioactive human type I IFNs by monitoring the activation of the ISGF3 pathway. Has an improved Type I IFN response compared to HEK-Blue IFN-alpha/beta (Cellosaurus=CVCL_KT26) (InvivoGen=hkb-ifnabv2).
Proper citation: RRID:CVCL_E8DB Copy
https://web.expasy.org/cellosaurus/CVCL_E8DB
Organism: Homo sapiens (Human)
Category: Transformed cell line
Comments: Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of the ISG54 promoter (InvivoGen=hkb-ifnabv2)., Characteristics: Designed to detect bioactive human type I IFNs by monitoring the activation of the ISGF3 pathway. Has an improved Type I IFN response compared to HEK-Blue IFN-alpha/beta (Cellosaurus=CVCL_KT26) (InvivoGen=hkb-ifnabv2).
Proper citation: RRID:CVCL_E8DB Copy
https://web.expasy.org/cellosaurus/CVCL_A7ID
Organism: Callithrix jacchus (White-tufted-ear marmoset)
Category: Embryonic stem cell
Comments: Miscellaneous: As no cell line name was provided in the paper, we assigned the name based on the abbreviation of the cell line description., Donor information: Embryo is sibling to that giving rise to CalJa ESC 17 (Cellosaurus=CVCL_A7IE)., Karyotypic information: 46,XY [4/9]; 46,X,+19 [2/9]; 47,XY,+19 [3/9] (PubMed=33711687)., Group: Non-human primate cell line.
Proper citation: RRID:CVCL_A7ID Copy
Possibly Discontinued
https://web.expasy.org/cellosaurus/CVCL_6809
Organism: Homo sapiens (Human)
Disease: Melanoma
Category: Cancer cell line
Comments: Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in Cellosaurus and May 2018. The major changes were: deletion of D18S51., Population: Caucasian., Part of: Wistar Institute melanoma cell line collection., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Proper citation: RRID:CVCL_6809 Copy
Contaminated
https://web.expasy.org/cellosaurus/CVCL_M629
Organism: Homo sapiens (Human)
Disease: Human papillomavirus-related endocervical adenocarcinoma
Category: Cancer cell line
Comments: Population: African American., Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=6451928; PubMed=20143388). Originally thought to originate from a male patient with a lung adenocarcinoma. The 2563 cell line is said to be derived from the MAC-21 cell line (Cellosaurus=CVCL_M627) which is also HeLa contaminated but which has never been tested for such a contamination..
Proper citation: RRID:CVCL_M629 Copy
https://web.expasy.org/cellosaurus/CVCL_AR50
Organism: Homo sapiens (Human)
Category: Transformed cell line
Comments: Miscellaneous: On the basis that LA-350 and LA-N-5 (Cellosaurus=CVCL_0389) are both established by Seeger R.C., that they share identical STR profiles and that LA-350 is said to originate from a patient suffering from neuroblastoma we have annotated them as being autologous cell lines., Characteristics: Secretes IgM kappa., From: Seeger, Robert C.; UCLA Center for Health Sciences; Los Angeles; USA.
Proper citation: RRID:CVCL_AR50 Copy
https://web.expasy.org/cellosaurus/CVCL_HF20
Organism: Homo sapiens (Human)
Category: Transformed cell line
Comments: Characteristics: This cell line is transfected with EBNA1t, a truncated version of EBV EBNA1 lacking the Gly-Gly-Ala repeats region. It has an enhanced ability to produce recombinant protein compared to HEK293-EBNA (Cellosaurus=CVCL_6974)., Characteristics: The use of recombinant protein expression vectors containing the EBV oriP in cell lines stably expressing EBV's EBNA1 protein significantly increases recombinant protein yield., Group: Patented cell line.
Proper citation: RRID:CVCL_HF20 Copy
https://web.expasy.org/cellosaurus/CVCL_3317
Organism: Homo sapiens (Human)
Disease: Melanoma
Category: Cancer cell line
Comments: Caution: The exact relationship between HMCB (Cellosaurus=CVCL_3317) and RPMI-7262/7272/7932/7962/7972 is not clear: all are derived from patient 'Bowes' melanoma., Anecdotal: The Bowes cell line is famous for its use in the identification and purification of tissue-type plasminogen activator, tPA., Population: Caucasian., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)., Group: Patented cell line.
Proper citation: RRID:CVCL_3317 Copy
Discontinued
https://web.expasy.org/cellosaurus/CVCL_6472
Organism: Homo sapiens (Human)
Disease: Cutaneous melanoma
Category: Cancer cell line
Comments: Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in Cellosaurus and May 2018. The major changes were: D13S317., Population: Caucasian., Part of: Wistar Institute melanoma cell line collection., Part of: COSMIC cell lines project., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Proper citation: RRID:CVCL_6472 Copy
Possibly Discontinued Discontinued
https://web.expasy.org/cellosaurus/CVCL_0580
Organism: Homo sapiens (Human)
Disease: Cutaneous melanoma
Category: Cancer cell line
Comments: Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in Cellosaurus and May 2018. The major changes were: D18S51., Population: Caucasian., Part of: Wistar Institute melanoma cell line collection., Part of: COSMIC cell lines project., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Proper citation: RRID:CVCL_0580 Copy
Possibly Discontinued Discontinued
https://web.expasy.org/cellosaurus/CVCL_8787
Organism: Homo sapiens (Human)
Disease: Cutaneous melanoma
Category: Cancer cell line
Comments: Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in Cellosaurus and May 2018. The major changes were: D18S51., Population: Caucasian., Part of: Wistar Institute melanoma cell line collection., Part of: COSMIC cell lines project., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Proper citation: RRID:CVCL_8787 Copy
Misidentified/Contaminated
https://web.expasy.org/cellosaurus/CVCL_1402
Organism: Homo sapiens (Human)
Disease: Melanoma
Category: Cancer cell line
Comments: Population: Caucasian., Part of: COSMIC cell lines project., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)., Problematic cell line: Misidentified/contaminated. Shown to be identical to MEL-Wei. This cell line was reported to be isogenic with LCL-Ho (Cellosaurus=CVCL_1868) but it does not have the same STR profile (PubMed=10508494; PubMed=20143388). According to DSMZ ACC-62 it is a human female cell line..
Proper citation: RRID:CVCL_1402 Copy
Partially Misidentified
https://web.expasy.org/cellosaurus/CVCL_5594
Organism: Homo sapiens (Human)
Disease: Breast carcinoma
Category: Cancer cell line
Comments: Part of: JWGray breast cancer cell line panel., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)., Problematic cell line: Partially misidentified. For a period of time Asterand (now BioIVT) mistakenly distributed SUM149PT (Cellosaurus=CVCL_3422) under the designation of SUM229PE. This leads to the publication of a STR profile (PubMed=25877200) which was almost identical to that of SUM149PT.., Group: Triple negative breast cancer (TNBC) cell line.
Proper citation: RRID:CVCL_5594 Copy
https://web.expasy.org/cellosaurus/CVCL_VQ57
Organism: Homo sapiens (Human)
Disease: Childhood B acute lymphoblastic leukemia
Category: Cancer cell line
Comments: Caution: Was originally (PubMed=23545498) described as originating from the Seraphina cell line (Cellosaurus=CVCL_M646) but was later (PubMed=28494875) shown to derive from RCH-ACV., Characteristics: Transduced with the retrovirus vector C/EBPaER-GFP which consist of CEBPA fused with the estrogen receptor hormone binding domain and GFP., Characteristics: Can efficiently be convert into cells exhibiting increased adherent, phagocytic and quiescent properties with a transcriptome resembling normal macrophages., Population: Caucasian.
Proper citation: RRID:CVCL_VQ57 Copy
Possibly Misidentified/Contaminated
https://web.expasy.org/cellosaurus/CVCL_A424
Organism: Homo sapiens (Human)
Disease: Pancreatic adenocarcinoma
Category: Cancer cell line
Comments: From: Scott and White Clinic; Temple; USA., Part of: UBC-40 urothelial bladder cancer cell line index., Problematic cell line: Possibly misidentified/contaminated. Reported by PubMed=11787853 to contain the same HPV18 sequences as the cervix carcinoma cell line C-4-I (Cellosaurus=CVCL_2253) and to lack mutations in KRAS, TP53, CDKN2A and DPC4 often found in pancreatic adenocarcinoma. Considered by PubMed=25997541 to be a bladder carcinoma cell line..
Proper citation: RRID:CVCL_A424 Copy
Discontinued
https://web.expasy.org/cellosaurus/CVCL_2787
Organism: Homo sapiens (Human)
Disease: Hepatitis C infection
Category: Cancer cell line
Comments: Caution: FLC-4 (Cellosaurus=CVCL_D204) is often stated to be synonymous with JHH-4, but a FLC-4 patent reference (Patent=US5804441) seems to indicate that it is derived from JHH-4 and has a different karyotype., Population: Japanese., Part of: MD Anderson Cell Lines Project., Part of: Liver Cancer Model Repository (LIMORE)., Part of: COSMIC cell lines project., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Proper citation: RRID:CVCL_2787 Copy
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