Resource Summary Report  New Search Previous Search Results

URL: https://dx.doi.org/10.17504/protocols.io.bsrpnd5n

Authors: Yeseong Kim, Fahmi Shibli, Takafumi Kubota

Summary: The review question: What is the clinical effectiveness of proton pump inhibitor (PPI) therapy on sleepdisturbances in patients with gastroesophageal reflux disease (GERD)?The following databases should be use: CENTRAL; MEDLINE; EMBASE; WHO-ICTRP; ClinicalTrials.gov.Types of study to be included: Prospective, randomized controlled trials describing PPI therapy for patients with GERD and sleep disturbances will be assessed for eligibility. Crossover studies, clusterrandomized studies, will be excluded. Studies conducted by quasi-experimental methods will be excluded. Retrospective studies will be excluded. No exclusion will be made for observation periods.Main outcome(s): Change in sleep time and quality.Additional outcome(s): Change in pH impedance parameters (acid exposure, number of refluxes episodes); Change in reflux symptoms; All adverse events: Proportion of people who developed an adverse event according to the original author's definition.We will perform meta-analysis of the above outcomes using random effect models.Besides, we will assess heterogeniety and publication bias.

Affiliations: Case Western Reserve University, Cleveland, Case Western Reserve University, Cleveland, University Hospitals Cleveland Medical Center

Version: 1

Publication Date: 2021

Expand All Collapse