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URL: https://dx.doi.org/10.17504/protocols.io.bbsfinbn

Authors: Shaohua Huang, Yi Xing, Lijuan Zhu, Ke Zhang

Summary: Background:Fixed-combination (FC) therapy is used in primary open-angle glaucoma (POAG) and ocular hypertension (OHT) patients who require more than one medication to reach their target intraocular pressure (IOP). Currently, there are several FC therapies available for the treatment of glaucoma. The FC of latanoprost/timolol (LTFC) is a commonly used. We will conduct a systematic review to compare the IOP-lowering effects of LTFC with other FCs for patients with POAG and OHT.Materials and methods: We will search PubMed, EMBASE, the Cochrane Library, and Web of Sciencefor randomized-controlled clinical trials and cross-over studies. The outcomes are mean IOP and IOP fluctuation after one month of treatment. Meta-analysis will be carried out using RevMan (version 5.1) software. After conducting meta-analyses, we will rate the quality of each meta-analysis as high, moderate, low, or very low using the “GRADE” system.

Associated Publications: Xing Y, Zhu L, Zhang K, Huang S (2020) The efficacy of the fixed combination of latanoprost and timolol versus other fixed combinations for primary open-angle glaucoma and ocular hypertension: A systematic review and meta-analysis. PLoS ONE 15(2): e0229682. doi: 10.1371/journal.pone.0229682

Affiliations: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China, Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China, Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China, Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China

External URL: https://doi.org/10.1371/journal.pone.0229682

Version: 1

Publication Date: 2020

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