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Frank Brosius 2019. Low-Dose Streptozotocin Induction Protocol (mouse). protocols.io dx.doi.org/10.17504/protocols.io.8izhuf6Copy Citation Copied
URL: https://dx.doi.org/10.17504/protocols.io.8izhuf6
Authors: Frank Brosius
Group: Diabetic Complications Consortium
Summary: This protocol is used by DiaComp members to induce diabetes in a number of the animal models developed by the consortium. STZ is toxic to the insulinproducing beta cells of the pancreas and used to induce a diabetes similar to a type I diabetic (Reference). Some reports suggest cellular toxicity outside of the pancreas. STZ also exhibits broad spectrum antibacterial properties and alters the gut microbiota. Please ensure that appropriate controls are included in all studies and complementary models considered (e.g. the Ins2Akita mouse).Diabetic Complications:
Affiliations: University of Arizona
External URL: https://www.diacomp.org/shared/document.aspx?id=19&docType=Protocol
Version: 2
Publication Date: 2019
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Source: Protocols.io
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