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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=401960101
Proper Citation: RRID:RGD_401960101
Description: Rattus norvegicus with name ZSF1-Leprfa/cp/Crl from RGD.
Species: Rattus norvegicus
Notes: This F1 obese model was developed by crossing rat strains with two separate leptin receptor mutations (fa and facp), In Charles River, they mate a Heterozygous ZDF (fa/+) with a Homozygous SHHF (cp/cp).This mating of ZDF and SHHF parent can produce obese ZSF1 (having fa and cp mutation from both parents) or lean ZSF1 (having just one copy of mutated Lepr, either cp or fa). The obese F1 develop insulin resistance, hyperglycaemia, and mild hypertension Charles River Laboratories
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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