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URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=41843
Proper Citation: RRID:MMRRC_041843-JAX
Description: Mus musculus with name STOCK Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Rnu7-SMN2*,PGK1-EGFP)4Dasch/Mmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: Developmental Biology, Models for Human Disease, Neurobiology; Mutation Type: Transgenic ; Collection:
Phenotype: kyphosis [MP:0000160]| abnormal blood flow velocity [MP:0000233]| abnormal heart morphology [MP:0000266]| thin ventricular wall [MP:0000280]| abnormal interventricular septum morphology [MP:0000281]| abnormal intestine morphology [MP:0000477]| abnormal autopod morphology [MP:0000572]| thick tail [MP:0000588]| short tail [MP:0000592]| tremors [MP:0000745]| muscle weakness [MP:0000747]| progressive muscle weakness [MP:0000748]| abnormal skeletal muscle morphology [MP:0000759]| abnormal motor neuron morphology [MP:0000937]| motor neuron degeneration [MP:0000938]| decreased motor neuron number [MP:0000939]| abnormal sensory neuron innervation pattern [MP:0000968]| abnormal sympathetic system morphology [MP:0001007]| abnormal innervation pattern to muscle [MP:0001052]| abnormal neuromuscular synapse morphology [MP:0001053]| abnormal phrenic nerve morphology [MP:0001078]| skin lesions [MP:0001212]| epidermal necrosis [MP:0001220]| decreased body weight [MP:0001262]| weight loss [MP:0001263]| decreased body size [MP:0001265]| hypoactivity [MP:0001402]| impaired coordination [MP:0001405]| abnormal gait [MP:0001406]| abnormal suckling behavior [MP:0001436]| poor grooming [MP:0001443]| limb grasping [MP:0001513]| impaired righting response [MP:0001523]| impaired limb coordination [MP:0001524]| impaired balance [MP:0001525]| abnormal apoptosis [MP:0001648]| reduced fertility [MP:0001921]| abnormal respiration [MP:0001943]| respiratory distress [MP:0001954]| hypopnea [MP:0001956]| apnea [MP:0001957]| increased thermal nociceptive threshold [MP:0001973]| postnatal lethality [MP:0002082]| premature death [MP:0002083]| abnormal embryonic tissue morphology [MP:0002085]| abnormal embryonic growth/weight/body size [MP:0002088]| abnormal tooth morphology [MP:0002100]| abnormal ear morphology [MP:0002102]| abnormal muscle morphology [MP:0002108]| abnormal tail morphology [MP:0002111]| abnormal outer ear morphology [MP:0002177]| abnormal artery morphology [MP:0002191]| abnormal CNS synaptic transmission [MP:0002206]| muscular atrophy [MP:0002269]| abnormal respiratory mechanics [MP:0002314]| abnormal sciatic nerve morphology [MP:0002651]| absent blastocoele [MP:0002663]| decreased vertical activity [MP:0002757]| dilated cardiomyopathy [MP:0002795]| abnormal PNS synaptic transmission [MP:0002913]| abnormal gastrocnemius morphology [MP:0003082]| abnormal skeletal muscle fiber morphology [MP:0003084]| abnormal synaptic transmission [MP:0003635]| oxidative stress [MP:0003674]| prolonged PR interval [MP:0003896]| increased heart rate variability [MP:0003928]| embryonic growth retardation [MP:0003984]| abnormal muscle electrophysiology [MP:0004145]| abnormal spine curvature [MP:0004174]| neuronal intranuclear inclusions [MP:0004191]| abnormal motor nerve collateral sprouting [MP:0004243]| abnormal miniature endplate potential [MP:0004835]| bradykinesia [MP:0005156]| decreased heart rate [MP:0005333]| positive geotaxis [MP:0005356]| abnormal action potential [MP:0005402]| abnormal axon morphology [MP:0005404]| axon degeneration [MP:0005405]| decreased pulmonary ventilation [MP:0005576]| cardiac interstitial fibrosis [MP:0005608]| abnormal lumbar dorsal root ganglion morphology [MP:0006404]| slow postnatal weight gain [MP:0008489]| abnormal synaptic bouton morphology [MP:0008571]| embryonic lethality [MP:0008762]| decreased survivor rate [MP:0008770]| increased skeletal muscle fiber size [MP:0009399]| decreased skeletal muscle fiber size [MP:0009400]| decreased skeletal muscle fiber diameter [MP:0009402]| decreased skeletal muscle fiber number [MP:0009406]| skeletal muscle fiber degeneration [MP:0009412]| skeletal muscle fiber atrophy [MP:0009413]| paraparesis [MP:0009434]| decreased birth body size [MP:0009703]| decreased grip strength [MP:0010053]| prolonged QRS complex duration [MP:0010392]| prolonged RR interval [MP:0010506]| increased heart left ventricle size [MP:0010579]| thin interventricular septum [MP:0010725]| postnatal lethality [MP:0011085]| complete penetrance [MP:0011086]| postnatal lethality [MP:0011088]| incomplete penetrance [MP:0011090]| neonatal lethality [MP:0011091]| incomplete penetrance [MP:0011092]| perinatal lethality [MP:0011094]| incomplete penetrance [MP:0011101]| prenatal lethality [MP:0011400]| complete penetrance [MP:0013178]| kyphosis [MP:0000160]| abnormal blood flow velocity [MP:0000233]| abnormal heart morphology [MP:0000266]| thin ventricular wall [MP:0000280]| abnormal interventricular septum morphology [MP:0000281]| tremors [MP:0000745]| muscle weakness [MP:0000747]| paralysis [MP:0000753]| abnormal skeletal muscle morphology [MP:0000759]| abnormal motor neuron morphology [MP:0000937]| motor neuron degeneration [MP:0000938]| decreased motor neuron number [MP:0000939]| abnormal spinal cord morphology [MP:0000955]| abnormal sensory neuron innervation pattern [MP:0000968]| abnormal sympathetic system morphology [MP:0001007]| abnormal innervation pattern to muscle [MP:0001052]| abnormal neuromuscular synapse morphology [MP:0001053]| epidermal necrosis [MP:0001220]| decreased body weight [MP:0001262]| weight loss [MP:0001263]| decreased body size [MP:0001265]| hypoactivity [MP:0001402]| impaired coordination [MP:0001405]| abnormal gait [MP:0001406]| abnormal suckling behavior [MP:0001436]| poor grooming [MP:0001443]| limb grasping [MP:0001513]| abnormal motor coordination/balance [MP:0001516]| impaired righting response [MP:0001523]| impaired limb coordination [MP:0001524]| impaired balance [MP:0001525]| irregular heartbeat [MP:0001636]| reduced fertility [MP:0001921]| respiratory distress [MP:0001954]| hypopnea [MP:0001956]| abnormal motor capabilities/coordination/movement [MP:0002066]| postnatal lethality [MP:0002082]| premature death [MP:0002083]| abnormal muscle morphology [MP:0002108]| no abnormal phenotype detected [MP:0002169]| abnormal innervation [MP:0002184]| abnormal artery morphology [MP:0002191]| abnormal CNS synaptic transmission [MP:0002206]| muscular atrophy [MP:0002269]| dilated cardiomyopathy [MP:0002795]| altered righting response [MP:0002862]| abnormal PNS synaptic transmission [MP:0002913]| abnormal gastrocnemius morphology [MP:0003082]| prolonged QT interval [MP:0003233]| decreased single cell response threshold [MP:0003466]| abnormal synaptic transmission [MP:0003635]| oxidative stress [MP:0003674]| prolonged PR interval [MP:0003896]| increased heart rate variability [MP:0003928]| abnormal muscle electrophysiology [MP:0004145]| neuronal intranuclear inclusions [MP:0004191]| abnormal motor nerve collateral sprouting [MP:0004243]| abnormal miniature endplate potential [MP:0004835]| bradykinesia [MP:0005156]| lethargy [MP:0005202]| decreased heart rate [MP:0005333]| abnormal action potential [MP:0005402]| abnormal axon morphology [MP:0005404]| cardiac interstitial fibrosis [MP:0005608]| abnormal lumbar dorsal root ganglion morphology [MP:0006404]| abnormal synaptic bouton morphology [MP:0008571]| decreased survivor rate [MP:0008770]| increased skeletal muscle fiber size [MP:0009399]| decreased skeletal muscle fiber size [MP:0009400]| decreased skeletal muscle fiber diameter [MP:0009402]| decreased skeletal muscle fiber number [MP:0009406]| skeletal muscle fiber degeneration [MP:0009412]| skeletal muscle fiber atrophy [MP:0009413]| decreased grip strength [MP:0010053]| prolonged QRS complex duration [MP:0010392]| prolonged RR interval [MP:0010506]| increased heart left ventricle size [MP:0010579]| thin interventricular septum [MP:0010725]| postnatal lethality [MP:0011085]| complete penetrance [MP:0011090]| perinatal lethality [MP:0011101]| incomplete penetrance [MP:0011400]| prenatal lethality [MP:0013178]
Affected Gene: |SMN2|Grm7|PGK1|SMN2|EGFP||Rnu7|Smn1|
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No rating or validation information has been found for STOCK Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Rnu7-SMN2*,PGK1-EGFP)4Dasch/Mmjax.
No alerts have been found for STOCK Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Rnu7-SMN2*,PGK1-EGFP)4Dasch/Mmjax.
Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)