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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=70429
Proper Citation: RRID:RGD_70429
Description: Rattus norvegicus with name AO from RGD.
Species: Rattus norvegicus
Notes: From ARC Compton, probably as "WAG", to Gowans, Oxford 1957. Appears to differ from other WAG sublines in having A at the agouti locus. Resistant to the development of experimental allergic encephalomyelitis upon treatment with a myelin basic protein-specific T cell line derived from an F1 hybrid between resistant AO and susceptible DA strain rats. This resistance was not abrogated by deletion of host's leukocytes using sublethal irradiation and cytotoxi drugs (Mostaricastrojkovic et al, 1992). Susceptible (2/4) to ocular infection with herpes simplex virus. PVG was relatively resistant (Nicholls et al, 1994). Met-enkephalin decreased H2O2 production by macrophages (contrast DA) (Radulovic et al, 1995).
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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