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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=626170599
Proper Citation: RRID:RGD_626170599
Description: Rattus norvegicus with name LE-Syngap1em1Sidb from RGD.
Species: Rattus norvegicus
Notes: This KO allele was generated by Sigma Advanced Genetic Engineering (SAGE) Labs (St. Louis, MO, US) by injecting CRISPR/Cas9 reagents and sgRNA targeting exon 8 (gtgcatagagcatgtcgtccAGG) into Long Evans (LE) zygotes. Founder #23 displayed a 2bp deletion and 1bp insertion, leading to a frameshift mutation in exon 8 of Syngap1, which prevents expression of the protein. Homozygous Syngap1 KO rats die perinatally, but heterozygous Syngap1 KO rats appear healthy and are fertile. Simons Initiative for the Developing Brain (SIDB), Institute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH8 9XD, UK. Contact SIDB Scientific Officer for enquiries on rat distribution ([email protected]).
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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