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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=329849011
Proper Citation: RRID:RGD_329849011
Description: Rattus norvegicus with name SD-Fosem1Yossi from RGD.
Species: Rattus norvegicus
Notes: SD rats (Slc:SD) in which the c-Fos gene (ENSRNOG00000008015) was disrupted by the CRISPR/Cas9 system. Two guide RNAs and Cas9 protein were injected into the pronucleus of fertilized eggs of SD rats. After injection, they were transferred into the oviducts of the recipient rats and born. The founder rat (line 12) showed abnormal teeth, and PCR and sequencing analysis revealed that 1,067 bases including Exon 1 were deleted. The founder rat were mated with SD rats and bred. National BioResource Project for the Rat in Japan
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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