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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=150429960
Proper Citation: RRID:RGD_150429960
Description: Rattus norvegicus with name WIC-Wwoxlde/Fta from RGD.
Species: Rattus norvegicus
Notes: Established from a closed colony of Wistar-Imamichi (WIC) rats as a spontaneous mutant exhibiting severe dwarfism, short lifespan (early postnatal lethality), and high incidence of epileptic seizures. Mutant rats showed growth retardation after 3 d of age, and at 21 d their weight was about 56% that of normal rats. Sequencing of the full-length Wwox transcript identified a 13-bp deletion in exon 9 in lde/lde rats. This mutation causes a frame shift, resulting in aberrant amino acid sequences at the C-terminal.
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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