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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=14398825
Proper Citation: RRID:RGD_14398825
Description: Rattus norvegicus with name SD-Fahem15Dlli-/- from RGD.
Species: Rattus norvegicus
Notes: This strain was produced by injecting Sprague Dawley embryo with CRISPR/Cas9 system targeting the exon 2 of rat Fah gene. The resulting mutation is line 15 with a frameshift deletion causing Fah null in homozygotes. None of the Fah-/- newborns survived longer than three days after birth in the absence of NTBC. Upon NTBC addition to the drinking water, the Fah-/- rats underwent normal growth and were indistinguishable from their WT littermates.
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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