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URL: https://rgd.mcw.edu/rgdweb/report/strain/main.html?id=126928150
Proper Citation: RRID:RGD_126928150
Description: Rattus norvegicus with name ACI.Cg.-Cdkn1bem4Musc from RGD.
Species: Rattus norvegicus
Notes: The CRISPR-Cas9 system targeted to exon 2 of the rat Cdkn1b was injected to zygotes derived from the Sprague-Dawley outbred rat strain. Two mutations with the highest potential impact on Cdkn1b function were transferred through the germline showing a 32-bp deletion (DEL-32, em1Musc) and a 65-bp deletion (DEL-65, em4Musc), both disrupting the open reading frame of the Cdkn1b gene. The selected mutations were breded to the ACI inbred strain for future study. This mutant strain ACI.Cg.-Cdkn1bem4Musc harbors 65-bp deletion of Cdkn1b exhibits same phenotype as the em1Musc with 32-bp deletion
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Source: Integrated Animals
Source Database: Rat Genome Database (RGD)
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