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Proper Citation: RRID:MGI:3810635
Description: Allele Detail: Targeted This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Targeted This is a legacy resource.
Phenotype: abnormal inflammatory response, abnormal B cell physiology, abnormal CD4-positive, alpha-beta T cell physiology, abnormal T cell apoptosis, spleen hyperplasia, increased circulating interleukin-12 level, increased circulating interleukin-6 level, increased interleukin-2 secretion, increased interleukin-4 secretion, increased interleukin-12 secretion, increased interleukin-6 secretion, increased spleen white pulp amount, increased susceptibility to endotoxin shock, increased tumor necrosis factor secretion, intestinal inflammation, increased circulating interleukin-10 level, increased circulating interleukin-1 beta level, increased T cell number, increased B cell number, weight loss, enlarged spleen, decreased survivor rate, decreased IgG2b level, decreased IgG2a level, abnormal cytotoxic T cell physiology, chronic inflammation, increased interleukin-1 beta secretion, increased interferon-gamma secretion, abnormal spleen morphology, abnormal myeloid dendritic cell morphology, increased circulating tumor necrosis factor level, increased interleukin-17 secretion, liver inflammation, lung inflammation, lymph node inflammation, abnormal macrophage activation involved in immune response, abnormal leukocyte morphology, abnormal B cell activation
Affected Gene: Tnfaip8l2
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Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI
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