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URL: http://www.hms.harvard.edu/bss/neuro/bornlab/index.htm
Proper Citation: Harvard Medical School; Department of Neurobiology; Born Lab (RRID:SCR_010643)
Description: In the Born Lab the goal is to seek to understand the circuitry of the mammalian cerebral cortex and how it endows us with the ability to see . . . and hear and think and talk. The approach is to study visual cortex of alert monkeys trained to report specific aspects of their visual experience. This allows us to define the neural correlates of specific percepts and then study their underlying mechanisms by activating or inactivating components of the circuit. Our primary tools are extracellular electrophysiologyboth with single electrodes and multi-electrode arraysand psychophysics. They are complemented by techniques that allow us to dissect and probe cortical circuitry: �� circuit tracing with genetically modified rabies viruses �� microstimulation to insert specific signals into cortical circuits �� cortical cooling (cryoloops) to reversibly inactivate circuit elements �� microarrays to identify molecular markers of neuronal subtypes �� optogenetics to improve the spatial and temporal specificity with which we can manipulate circuits Current Projects: *Dissecting parallel pathways. *Probing cortico-cortical feedback.
Synonyms: Born Lab
Resource Type: laboratory portal, organization portal, portal, data or information resource
Keywords: cortical circuitry, visual perception
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