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URL: http://www2.bsc.gwu.edu/bsc/oneproj.php?pkey=8
Proper Citation: Medical Therapy of Prostatic Symptoms (RRID:SCR_001556)
Description: Multi-center double-masked, placebo-controlled randomized clinical trial designed to evaluate the long-term efficacy of finasteride, or doxazosin, or the combination of both, in delaying or preventing the clinical progression of symptomatic benign prostatic hyperplasia (BPH). MTOPS was the largest and longest study to test whether drug therapy can prevent or delay the noncancerous growth of the prostate. A unique feature of MTOPS that has not been done in prior studies of pharmacotherapy of BPH is the biopsy substudy. A total of 1,082 volunteers from the 2,931 participants randomized during the full-scale phase are currently participating in this substudy. Biopsies of the prostate will be obtained on these volunteers at predetermined times during the course of the trial to evaluate the status of the prostate at key event times. The purpose of the substudy was to provide additional information regarding the histopathobiology of BPH and to test existing biomarkers for their prognostic ability regarding response to drug therapy.
Abbreviations: MTOPS
Synonyms: Medical Therapy of Prostatic Symptoms (MTOPS)
Resource Type: resource, clinical trial
Keywords: male, adult human, prostate, placebo, finasteride, doxazosin, drug, treatment, prostate biopsy, tissue, prostate tissue, intervention, biomaterial supply resource, biomarker, serum
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