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Proper Citation: SignaLink (RRID:SCR_003569)
Description: An integrated resource to analyze signaling pathway cross-talks, transcription factors, miRNAs and regulatory enzymes. The multi-layered database structure is made up of signaling pathways, their pathway regulators (e.g., scaffold and endocytotic proteins) and modifier enzymes (e.g., phosphatases, ubiquitin ligases), as well as transcriptional and post-transcriptional regulators of all of these components. The website allows the interactive exploration of how each signaling protein is regulated. Features * experimental data not only from humans but from two invertebrate model organisms, C. elegans and D. melanogaster; * combines manual curation with large-scale datasets; * provides confidence scores for each interaction; * operates a customizable download page with multiple file formats (e.g., BioPAX, Cytoscape, SBML).
Abbreviations: SignaLink
Resource Type: database, data or information resource
Defining Citation: PMID:23331499, PMID:20542890
Keywords: analyze, signaling, pathway, cross-talk, transcription factor, mirna, regulatory enzyme, protein, interaction, regulatory network, signaling pathway, scaffold protein, enzyme, signaling, drug discovery, regulatory, network, post-transcriptional regulator, transcriptional regulator, protein-protein interaction, post-translational modification, pathway regulator, FASEB list
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